The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
In Vitro and In Vivo: The Story of Nonoxynol 9
Abstract
There is an urgent need to expand the range of interventions to prevent HIV transmission and acquisition, especially those that can be controlled by women. Microbicides, defined as antimicrobial products that can be applied topically for the prevention of HIV and other sexually transmitted infections, may offer one of the most promising preventive interventions, because they could be inexpensive, readily available, and widely acceptable. The first microbial product to be clinically evaluated contained Nonoxynol-9 (nonylpenoxypolyethoxyethanol [N-9]), a nonionic surfactant, as the active agent. This article presents a review of the in vitro, ex vivo, and animal model data on the safety of N-9 and a critical analysis of their predictive power based on the results of multiple safety and efficacy trials.
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Cites
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Cited by
The iron-sulfur clusters of dehydratases are primary intracellular targets of copper toxicity
Macomber, L., & Imlay, J. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812808106 · Cited by 1,117
Role of Tyrosine Kinase Inhibitors in Cancer Therapy
Arora, A., & Scholar, E. M. (2005) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.084145 · Cited by 1,014
The effect of excess copper on growth and physiology of important food crops: a review
Adrees, M., Ali, S., Rizwan, M., Ibrahim, M., Abbas, F., Farid, M., Zia-ur-Rehman, M., Irshad, M. K., & Bharwana, S. A. (2015) · Environmental Science and Pollution Research · doi:10.1007/s11356-015-4496-5 · Cited by 772
Rekart, M. L. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67732-x · Cited by 503
Schade, R., Calzado, E. G., Sarmiento, R., Chacana, P. A., Porankiewicz-Asplund, J., & Terzolo, H. R. (2005) · Alternatives to Laboratory Animals · doi:10.1177/026119290503300208 · Cited by 381
Metadata
- Authors
- Hillier, S. L., Moench, T., Shattock, R., Black, R., Reichelderfer, P., & Veronese, F.
- Venue
- JAIDS Journal of Acquired Immune Deficiency Syndromes
- Published
- 2005-05-01
- Volume
- 39
- Issue
- 1
- Pages
- 1-8
- ISSN
- 1525-4135 (ISSN-L)
- OpenAlex
- W1988706339
- Cited by
- 572
- References
- 25
- FWCI
- 25.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hillier, S. L., Moench, T., Shattock, R., Black, R., Reichelderfer, P., & Veronese, F. (2005). In Vitro and In Vivo: The Story of Nonoxynol 9. JAIDS Journal of Acquired Immune Deficiency Syndromes. https://doi.org/10.1097/01.qai.0000159671.25950.74
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
