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Tacrolimus Pharmacogenetics: The CYP3A5*1 Allele Predicts Low Dose-Normalized Tacrolimus Blood Concentrations in Whites and South Asians
Abstract
Previously, we demonstrated that the dose-normalized tacrolimus blood concentration after renal transplantation was associated with a single nucleotide polymorphism (SNP) in the CYP3AP1 gene, probably through linkage with an SNP in the CYP3A5 gene. Individuals with at least one CYP3A5*1 allele synthesize CYP3A5 and CYP3A5*3/*3 homozygotes do not. We now present results with direct typing of the CYP3A5 genotype for this group of 180 kidney-only transplant recipients from a single center. South Asian and white patients with at least one CYP3A5*1 allele achieved twofold lower dose-normalized tacrolimus blood concentrations compared with CYP3A5*3/*3 homozygotes, confirming our previous findings for the CYP3AP1 SNP. There was a significant delay in achieving target blood concentrations in those with at least one CYP3A5*1 allele. Determination of the CYP3A5*1/*3 genotype could be used to predict the tacrolimus dose requirement and, given incomplete linkage, would be better than determination of the CYP3AP1 genotype.
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Citations
Cited by
Pharmacogenetics, Drug-Metabolizing Enzymes, and Clinical Practice
Gardiner, S. J., & Begg, E. J. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.6 · Cited by 406
Thishya, K., Vattam, K. K., Naushad, S. M., Raju, S. B., & Kutala, V. K. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191921 · Cited by 65
Metadata
- Authors
- MacPhee, I. A. M., Fredericks, S., Mohamed, M., Moreton, M., Carter, N. D., Johnston, A., Goldberg, L., & Holt, D. W.
- Venue
- Transplantation
- Published
- 2005-02
- Volume
- 79
- Issue
- 4
- Pages
- 499-502
- ISSN
- 0041-1337 (ISSN-L)
- OpenAlex
- W2077109037
- Cited by
- 207
- References
- 0
- FWCI
- 13.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Tacrolimus Pharmacogenetics: The CYP3A5*1 Allele Predicts Low Dose-Normalized Tacrolimus Blood Concentrations in Whites and South Asians. https://app.cochat.ai/papers/10.1097/01.tp.0000151766.73249.12
- The paper
- MacPhee, I. A. M., Fredericks, S., Mohamed, M., Moreton, M., Carter, N. D., Johnston, A., Goldberg, L., & Holt, D. W. (2005). Tacrolimus Pharmacogenetics: The CYP3A5*1 Allele Predicts Low Dose-Normalized Tacrolimus Blood Concentrations in Whites and South Asians. Transplantation. https://doi.org/10.1097/01.tp.0000151766.73249.12
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