Selective deficit in no-go performance induced by blockade of prefrontal cortical α2-adrenoceptors in monkeys
Abstract
Two monkeys (Macaca mulatta) were trained to make a go response (go to touch a computer screen) when a red signal (go signal) was presented or a no-go response (inhibit the screen-touching action) when a green signal (no-go signal) was given. The alpha2-adrenergic antagonist yohimbine was infused locally, bilaterally and continuously for 8 days into the prefrontal cortex (PFC) by using mini-osmotic pump. The no-go but not go performance was selectively impaired during the 8-day administration of yohimbine: the monkeys showed an inability to inhibit the touching response to the no-go signal, indicating that there was a deficit in the inhibitory ability of the animals. Similar infusion of saline into the same cortical area was without effect. The present study provides behavioral pharmacological evidence that alpha2-adrenoceptors in the PFC are involved in the neural mechanisms underlying response inhibition.
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Blockade of α2 receptors selectively within the monkey PFC can recreate many of the key symptoms of ADHD.
“Importantly, blockade of α2 receptors selectively within the monkey PFC can recreate many of the key symptoms of ADHD.”
From Catecholamine Influences on Dorsolateral Prefrontal Cortical Networks (2011) · cites this paper as [69]
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References 15 · Cited by 69
- Authors
- Ma, C.-L., Qi, X.-L., Peng, J.-Y., & Li, B.-M.
- Affiliations
- Fudan University (CN)
- Venue
- NeuroReport
- Published
- 2003-05-23
- Volume
- 14
- Issue
- 7
- Pages
- 1013-1016
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2025643798
- Cited by
- 69
- References
- 15
- Citations by year
- 2023: 1 · 2021: 4 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 7 · 2014: 4 · 2013: 6 · 2012: 2
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- alpha2-adrenoceptors, prefrontal cortex, yohimbine, response inhibition, inhibitory control, behavioral pharmacology
- MeSH terms
- Animals, Female, Macaca mulatta, Neural Inhibition, Photic Stimulation, Psychomotor Performance, Prefrontal Cortex, Receptors, Adrenergic, alpha-2, Motor Skills Disorders, Adrenergic alpha-2 Receptor Antagonists
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