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Cited by 317Prenatal Substance Exposure EffectsOpioid Use Disorder TreatmentSubstance Abuse Treatment and Outcomes

The DOI matches its Crossref record, with a small difference in title or year; 47 of the 47 references it cites were found in a registry or an index.

Opioid Abuse and Dependence during Pregnancy: Temporal Trends and Obstetrical Outcomes

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Maeda, Ayumi, Bateman, Brian T., Clancy, Caitlin R., Creanga, Andreea A., Leffert, Lisa R.·2014·Anesthesiology
DOI 10.1097/aln.0000000000000472
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Abstract

Background: The authors investigated nationwide trends in opioid abuse or dependence during pregnancy and assessed the impact on maternal and obstetrical outcomes in the United States. Methods: Hospitalizations for delivery were extracted from the Nationwide Inpatient Sample from 1998 to 2011. Temporal trends were assessed and logistic regression was used to examine the associations between maternal opioid abuse or dependence and obstetrical outcomes adjusting for relevant confounders. Results: The prevalence of opioid abuse or dependence during pregnancy increased from 0.17% (1998) to 0.39% (2011) for an increase of 127%. Deliveries associated with maternal opioid abuse or dependence compared with those without opioid abuse or dependence were associated with an increased odds of maternal death during hospitalization (adjusted odds ratio [aOR], 4.6; 95% CI, 1.8 to 12.1, crude incidence 0.03 vs. 0.006%), cardiac arrest (aOR, 3.6; 95% CI, 1.4 to 9.1; 0.04 vs. 0.01%), intrauterine growth restriction (aOR, 2.7; 95% CI, 2.4 to 2.9; 6.8 vs. 2.1%), placental abruption (aOR, 2.4; 95% CI, 2.1 to 2.6; 3.8 vs. 1.1%), length of stay more than 7 days (aOR, 2.2; 95% CI, 2.0 to 2.5; 3.0 vs. 1.2%), preterm labor (aOR, 2.1; 95% CI, 2.0 to 2.3; 17.3 vs. 7.4%), oligohydramnios (aOR, 1.7; 95% CI, 1.6 to 1.9; 4.5 vs. 2.8%), transfusion (aOR, 1.7; 95% CI, 1.5 to 1.9; 2.0 vs. 1.0%), stillbirth (aOR, 1.5; 95% CI, 1.3 to 1.8; 1.2 vs. 0.6%), premature rupture of membranes (aOR, 1.4; 95% CI, 1.3 to 1.6; 5.7 vs. 3.8%), and cesarean delivery (aOR, 1.2; 95% CI, 1.1 to 1.3; 36.3 vs. 33.1%). Conclusions: Opioid abuse or dependence during pregnancy is associated with considerable obstetrical morbidity and mortality, and its prevalence is dramatically increasing in the United States. Identifying preventive strategies and therapeutic interventions in pregnant women who abuse drugs are important priorities for clinicians and scientists.

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  1. 2006, Major increases in opioid analgesic abuse in the United States: Concerns and strategies., Drug Alcohol Depend, 81, 103, 10.1016/j.drugalcdep.2005.05.009 · DOI

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Metadata

Authors
Maeda, A., Bateman, B. T., Clancy, C. R., Creanga, A. A., & Leffert, L. R.
Affiliations
  • Massachusetts General Hospital (US)
  • Brigham and Women's Hospital (US)
  • Centers for Disease Control and Prevention (US)
Corresponding author
Leffert, Lisa R.
ORCID
Venue
Anesthesiology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2014-12
Volume
121
Issue
6
Pages
1158-1165
ISSN
0003-3022 (ISSN-L)
DOI
10.1097/aln.0000000000000472
OpenAlex
W2009000630
Cited by
317
References
47
Citations by year
2026: 12 · 2025: 26 · 2024: 27 · 2023: 27 · 2022: 30 · 2021: 46 · 2020: 45 · 2019: 38 · 2018: 27 · 2017: 21 · 2016: 5 · 2015: 11 · 2014: 2
FWCI
12.17
Type
journal article
Language
en
Open access
Locations
  • Anesthesiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords
opioid use during pregnancy, maternal opioid dependence, maternal mortality, pregnancy complications, preterm labor, fetal growth restriction, placental abruption, stillbirth, neonatal abstinence syndrome, neonatal intensive care, neonatal mortality, temporal trends, hospitalization outcomes, United States, National Inpatient Sample, opioid epidemic, maternal health policy, prenatal care access, substance use disorders
MeSH terms
Adolescent, Adult, Female, Humans, Insurance, Health, Obstetric Labor Complications, Maternal Mortality, Opioid-Related Disorders, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Socioeconomic Factors, United States, Prevalence, Young Adult

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