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Cited by 265

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Obesity-induced Insulin Resistance and Hyperglycemia: Etiologic Factors and Molecular Mechanisms

Open access
Martyn, J A. Jeevendra, Kaneki, Masao, Yasuhara, Shingo, Warner, David S., Warner, Mark A.·2008·Anesthesiology
DOI 10.1097/aln.0b013e3181799d45
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Abstract

Obesity is a major cause of type 2 diabetes, clinically evidenced as hyperglycemia. The altered glucose homeostasis is caused by faulty signal transduction via the insulin signaling proteins, which results in decreased glucose uptake by the muscle, altered lipogenesis, and increased glucose output by the liver. The etiology of this derangement in insulin signaling is related to a chronic inflammatory state, leading to the induction of inducible nitric oxide synthase and release of high levels of nitric oxide and reactive nitrogen species, which together cause posttranslational modifications in the signaling proteins. There are substantial differences in the molecular mechanisms of insulin resistance in muscle versus liver. Hormones and cytokines from adipocytes can enhance or inhibit both glycemic sensing and insulin signaling. The role of the central nervous system in glucose homeostasis also has been established. Multipronged therapies aimed at rectifying obesity-induced anomalies in both central nervous system and peripheral tissues may prove to be beneficial.

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Metadata

Authors
Martyn, J. A. J., Kaneki, M., Yasuhara, S., Warner, D. S., & Warner, M. A.
Venue
Anesthesiology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2008-07-01
Volume
109
Issue
1
Pages
137-148
ISSN
0003-3022 (ISSN-L)
DOI
10.1097/aln.0b013e3181799d45
OpenAlex
W2091805259
Cited by
265
References
44
FWCI
6.13
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Obesity-induced Insulin Resistance and Hyperglycemia: Etiologic Factors and Molecular Mechanisms. https://app.cochat.ai/papers/10.1097/aln.0b013e3181799d45
The paper
Martyn, J. A. J., Kaneki, M., Yasuhara, S., Warner, D. S., & Warner, M. A. (2008). Obesity-induced Insulin Resistance and Hyperglycemia: Etiologic Factors and Molecular Mechanisms. Anesthesiology. https://doi.org/10.1097/aln.0b013e3181799d45

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.