Cooccurrence of and Remission From General Anxiety, Depression, and Posttraumatic Stress Disorder Symptoms After Acute Lung Injury: A 2-Year Longitudinal Study
Open accessAbstract
OBJECTIVE: To evaluate the cooccurrence, and predictors of remission, of general anxiety, depression, and posttraumatic stress disorder symptoms during 2-year follow-up in survivors of acute lung injury treated in an ICU. DESIGN: Prospective cohort study, with follow-up at 3, 6, 12, and 24 months post-acute lung injury. SETTING: Thirteen medical and surgical ICUs in four hospitals. PATIENTS: Survivors among 520 patients with acute lung injury. MEASUREMENTS AND MAIN RESULTS: The outcomes of interest were measured using the Hospital Anxiety and Depression Scale anxiety and depression subscales (scores ≥ 8 indicating substantial symptoms) and the Impact of Event Scale-Revised (scores ≥ 1.6 indicating substantial posttraumatic stress disorder symptoms). Of the 520 enrolled patients, 274 died before 3-month follow-up; 186 of 196 consenting survivors (95%) completed at least one Hospital Anxiety and Depression Scale and Impact of Event Scale-Revised assessment during 2-year follow-up, and most completed multiple assessments. Across follow-up time points, the prevalence of suprathreshold general anxiety, depression, and posttraumatic stress disorder symptoms ranged from 38% to 44%, 26% to 33%, and 22% to 24%, respectively; more than half of the patients had suprathreshold symptoms in at least one domain during 2-year follow-up. The majority of survivors (59%) with any suprathreshold symptoms were above threshold for two or more types of symptoms (i.e., general anxiety, depression, and/or posttraumatic stress disorder). In fact, the most common pattern involved simultaneous general anxiety, depression, and posttraumatic stress disorder symptoms. Most patients with general anxiety, depression, or posttraumatic stress disorder symptoms during 2-year follow-up had suprathreshold symptoms at 24-month (last) follow-up. Higher Short-Form-36 physical functioning domain scores at the prior visit were associated with a greater likelihood of remission from general anxiety and posttraumatic stress disorder symptoms during follow-up. CONCLUSIONS: The majority of acute lung injury survivors had clinically significant general anxiety, depression, or posttraumatic stress disorder symptoms, and these symptoms tended to co-occur across domains. Better physical functioning during recovery predicted subsequent remission of general anxiety and posttraumatic stress disorder symptoms.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
As many as 66% of acute respiratory distress syndrome survivors report clinically important depression, anxiety, and PTSD symptoms at 1 year post-discharge.
“As many as 66% of acute respiratory distress syndrome (ARDS) survivors report clinically important symptoms of depression, anxiety, and post-traumatic stress disorder (PTSD) at 1 year post-discharge.5–8”
From Effects of mindfulness training programmes delivered by a self-directed mobile app and by telephone compared with an education programme for survivors of critical illness: A pilot randomised clinical trial (2019) · cites this paper as [6]
The Abstract (Measurements and Main Results) reports substantial anxiety, depression, and PTSD symptoms among acute lung injury survivors, with more than half having symptoms in at least one domain during two-year follow-up. It does not report 66% at one year. The Study population section also dates the 12-month assessment from the onset of lung injury, not hospital discharge. (LLM, conf=0.87)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 54 · Cited by 128
Research works printed but not linked: 3
- [18]Weiss DS Marmar CR Wilson JPKT The Impact of Events Scale - Revised Assessing Psychological Trauma and PTSD: a Handbook for Practitioners 1997 New York Guilford Press 399 411
- [43]Otto MW Smits JAJ Exercise for Mood and Anxiety: Proven Strategies for Overcoming Depression and Enhancing Well-Being 2011 New York, NY Oxford University Press
- [44]Matta Mello Portugal E Cevada T Sobral Monteiro-Junior R Neuroscience of exercise: from neurobiology mechanisms to mental health Neuropsychobiology 2013 68 1 1 14 23774826
- Authors
- Bienvenu, O. J., Colantuoni, E., Mendez-Tellez, P. A., Shanholtz, C., Dennison-Himmelfarb, C. R., Pronovost, P. J., & Needham, D. M.
- Affiliations
- Johns Hopkins University (US)
- University of Maryland, Baltimore (US)
- Venue
- Critical Care Medicine
- Published
- 2015-03
- Volume
- 43
- Issue
- 3
- Pages
- 642-653
- ISSN
- 0090-3493 (ISSN-L)
- PMC
- PMC4336582
- OpenAlex
- W2316769215
- Cited by
- 128
- References
- 54
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 9 · 2023: 18 · 2022: 12 · 2021: 17 · 2020: 7 · 2019: 11 · 2018: 10 · 2017: 15 · 2016: 8 · 2015: 4
- FWCI
- 7.22
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5p50hl073994-05, UL1TR000424)
- National Heart, Lung, and Blood Institute (P50 HL-073994, K24HL088551, P050 HL 73994, R01HL088045)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Keywords
- acute lung injury, general anxiety, depression, post-traumatic stress disorder, psychiatric symptoms, remission, symptom co-occurrence, intensive care unit survivors, physical function, long-term outcomes
- MeSH terms
- Adult, Aged, Anxiety, Depression, Humans, Intensive Care Units, Longitudinal Studies, Middle Aged, Prospective Studies, Psychiatric Status Rating Scales, Remission, Spontaneous, Risk Factors, Stress Disorders, Post-Traumatic, Health Behavior, Prevalence, Critical Illness, Survivors, Acute Lung Injury
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
