Early type II fiber atrophy in intensive care unit patients with nonexcitable muscle membrane
Abstract
Objective Intensive care unit-acquired weakness indicates increased morbidity and mortality. Nonexcitable muscle membrane after direct muscle stimulation develops early and predicts intensive care unit-acquired weakness in sedated, mechanically ventilated patients. A comparison of muscle histology at an early stage in intensive care unit-acquired weakness has not been done. We investigated whether nonexcitable muscle membrane indicates fast-twitch myofiber atrophy during the early course of critical illness. Design Prospective observational study. Setting Two intensive care units at Charité University Medicine, Berlin. Patients Patients at increased risk for development of intensive care unit-acquired weakness, indicated by Sepsis-related Organ Failure Assessment scores ≥8 on 3 of 5 consecutive days within their first week in the intensive care unit. Interventions None. Measurements and main results Electrophysiological compound muscle action potentials after direct muscle stimulation and muscle biopsies were obtained at median days 7 and 5, respectively. Patients with nonexcitable muscle membranes (n = 15) showed smaller median type II cross-sectional areas (p Conclusion We suggest that electrophysiological nonexcitable muscle membrane predicts preferential type II fiber atrophy in intensive care unit patients during early critical illness.
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In ICUAW, atrophy predominantly occurs in fast twitch/type II myofibres and is mainly mediated by the ubiquitin-proteasome system.
“In ICUAW, atrophy predominantly occurs in fast twitch/type II myofibres 6 and is mainly mediated by the ubiquitin‐proteasome system.”
From Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting (2022) · cites this paper as [6]
Both MuRF1 and Atrogin-1 are increased early and persistently during critical illness and possibly mediate muscle atrophy in ICUAW patients.
“Both MuRF1 and Atrogin‐1 are increased early and persistently during critical illness and possibly mediate muscle atrophy in ICUAW patients.”
From Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting (2022) · cites this paper as [6]
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Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting
Zanders, L., Kny, M., Hahn, A., Schmidt, S., Wundersitz, S., Todiras, M., Lahmann, I., Bandyopadhyay, A., Wollersheim, T., Kaderali, L., et al. (2022) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12867 · Cited by 225 · see citing works
“early and persistently during critical illness and possibly mediate muscle atrophy in ICUAW patients.(4,6) Inflammation and sepsis are major risk factors for ICUAW.”
BackgroundSelf-citationDeletion of Nlrp3 protects from inflammation-induced skeletal muscle atrophy
Huang, N., Kny, M., Riediger, F., Busch, K., Schmidt, S., Luft, F. C., Slevogt, H., & Fielitz, J. (2017) · Intensive Care Medicine Experimental · doi:10.1186/s40635-016-0115-0 · Cited by 95 · see citing works
Self-citation
- Authors
- Bierbrauer, J., Koch, S., Olbricht, C., Hamati, J., Lodka, D., Schneider, J., Luther-Schröder, A., Kleber, C., Faust, K., Wiesener, S., Spies, C. D., Spranger, J., Spuler, S., Fielitz, J., & Weber-Carstens, S.
- Affiliations
- Charité – Universitätsmedizin Berlin (DE)
- ORCID
- Venue
- Critical Care Medicine
- Published
- 2012-02
- Volume
- 40
- Issue
- 2
- Pages
- 647-650
- ISSN
- 0090-3493 (ISSN-L)
- OpenAlex
- W2315812255
- Cited by
- 88
- References
- 0
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 8 · 2023: 4 · 2022: 7 · 2021: 8 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 8 · 2014: 9 · 2013: 10 · 2012: 4
- FWCI
- 5.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Surgery › Muscle and Compartmental Disorders
- Keywords
- ICU-acquired weakness, fast-twitch muscle, critical illness, sepsis, muscle biopsy, compound muscle action potential, mechanical ventilation, sedation
- MeSH terms
- Action Potentials, Adult, Aged, Atrophy, Critical Care, Electromyography, Female, Humans, Intensive Care Units, Male, Membranes, Middle Aged, Predictive Value of Tests, Prospective Studies, Severity of Illness Index, Time Factors, Cohort Studies, Critical Illness, Muscle Fibers, Skeletal, Risk Assessment, Statistics, Nonparametric, Muscle Weakness
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