The DOI matches its Crossref record, with a small difference in title or year; 71 of the 71 references it cites were found in a registry or an index.
Cognitive and physical rehabilitation of intensive care unit survivors: Results of the RETURN randomized controlled pilot investigation*
Open accessAbstract
BACKGROUND: Millions of patients who survive medical and surgical general intensive care unit care every year experience newly acquired long-term cognitive impairment and profound physical and functional disabilities. To overcome the current reality in which patients receive inadequate rehabilitation, we devised a multifaceted, in-home, telerehabilitation program implemented using social workers and psychology technicians with the goal of improving cognitive and functional outcomes. METHODS: This was a single-site, feasibility, pilot, randomized trial of 21 general medical/surgical intensive care unit survivors (8 controls and 13 intervention patients) with either cognitive or functional impairment at hospital discharge. After discharge, study controls received usual care (sporadic rehabilitation), whereas intervention patients received a combination of in-home cognitive, physical, and functional rehabilitation over a 3-month period via a social worker or master's level psychology technician utilizing telemedicine to allow specialized multidisciplinary treatment. Interventions over 12 wks included six in-person visits for cognitive rehabilitation and six televisits for physical/functional rehabilitation. Outcomes were measured at the completion of the rehabilitation program (i.e., at 3 months), with cognitive functioning as the primary outcome. Analyses were conducted using linear regression to examine differences in 3-month outcomes between treatment groups while adjusting for baseline scores. RESULTS: Patients tolerated the program with only one adverse event reported. At baseline both groups were well-matched. At 3-month follow-up, intervention group patients demonstrated significantly improved cognitive executive functioning on the widely used and well-normed Tower test (for planning and strategic thinking) vs. controls (median [interquartile range], 13.0 [11.5-14.0] vs. 7.5 [4.0-8.5]; adjusted p < .01). Intervention group patients also reported better performance (i.e., lower score) on one of the most frequently used measures of functional status (Functional Activities Questionnaire at 3 months vs. controls, 1.0 [0.0 -3.0] vs. 8.0 [6.0-11.8], adjusted p = .04). CONCLUSIONS: A multicomponent rehabilitation program for intensive care unit survivors combining cognitive, physical, and functional training appears feasible and possibly effective in improving cognitive performance and functional outcomes in just 3 months. Future investigations with a larger sample size should be conducted to build on this pilot feasibility program and to confirm these results, as well as to elucidate the elements of rehabilitation contributing most to improved outcomes.
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“Three studies, one RCT (628) and two observational studies (629, 630) evaluated early post-hospital follow-up in patients with critical illness.”
From Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. (2021) · cites this paper as [630]
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“Ethics consultation did not result in a reduction in ICU stay, hospital stay, or life-sustaining treatments in patients who did not survive to discharge.”
From Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. (2021) · cites this paper as [542]
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“Neither study demonstrated an effect of interventions on mortality.”
From Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. (2021) · cites this paper as [542]
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“A feasibility, pilot, randomised trial in general medical/surgical ICU survivors comparing usual care to an intervention of combined in-home cognitive, physical, and functional rehabilitation following discharge showed improved executive functioning at 3 months [633].”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [633]
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Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
The Timed “Up & Go”: A Test of Basic Functional Mobility for Frail Elderly Persons
Podsiadlo, D., & Richardson, S. (1991) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1991.tb01616.x · Cited by 14,418
The Mini‐Mental State Examination: A Comprehensive Review
Tombaugh, T. N., & McIntyre, N. J. (1992) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1992.tb01992.x · Cited by 5,152
Fitness Effects on the Cognitive Function of Older Adults: A Meta-Analytic Study
Colcombe, S., & Kramer, A. F. (2003) · Psychological Science · doi:10.1111/1467-9280.t01-1-01430 · Cited by 3,782
Tracey, K. J. (2002) · Nature · doi:10.1038/nature01321 · Cited by 3,728
Schweickert, W. D., Pohlman, M. C., Pohlman, A. S., Nigos, C., Pawlik, A. J., Esbrook, C. L., Spears, L., Miller, M., Franczyk, M., Deprizio, D., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60658-9 · Cited by 3,339
Measurement of Functional Activities in Older Adults in the Community
PFEFFER, R. I., Kurosaki, T., Harrah, C. H., Chance, J. M., & Filos, S. (1982) · Journal of Gerontology · doi:10.1093/geronj/37.3.323 · Cited by 2,978
The Activities-specific Balance Confidence (ABC) Scale
Powell, L. E., & Myers, A. M. (1995) · The Journals of Gerontology Series A · doi:10.1093/gerona/50a.1.m28 · Cited by 2,877
Long-term cognitive impairment and functional disability among survivors of severe sepsis.
Iwashyna, T. J., Ely, E. W., Smith, D. M., & Langa, K. M. (2010) · JAMA · doi:10.1001/jama.2010.1553 · Cited by 2,582
Self-citationKatz, S. (1963) · JAMA · doi:10.1001/jama.1963.03060120024016 · Cited by 2,421
Flagged first, then by citations
Research works printed but not linked: 3
- Christie, 2003, Am J Respir Crit Care Med, 169, A781
- Jette, 1987, Arch Phys Med Rehabil, 68, 735
- Baker, 2010, Arch Neurol, 67, 71
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Items 301–317 of 317
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Verdonk, F. (2016) · theses.fr (ABES) · doi:10.70675/8d3a9e0ez15f7z446bzb0e4z56e24e61058a
Cognitive Rehabilitation Interventions in the Intensive Care Unit: A Systematic Integrative Review
Lassen, K. C., Lærkner, E., Jensen, J., Egerod, I., Christensen, J., Jørgensen, K., Kjærgaard, R. S., Olausson, S., Wøien, H., Nielsen, A. M., et al. (2026) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.70240
Collet, M. O., Svendsen, L. S., Harbeck, S. V., Lærkner, E., Egerod, I., & Nielsen, A. M. (2026) · Intensive and Critical Care Nursing · doi:10.1016/j.iccn.2026.104435
Kakde, S. P., Arora, N., Kakde, M. P., & Kakade, S. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1833028
Besnier, E., & Vardon, F. (2026) · EMC-Anesthésie réanimation/Encyclopédie médico-chirurgicale. Anesthésie, réanimation · doi:10.1016/s0246-0289(26)49698-x
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Fraiha, Y. A., Devanney, J., McNichol, M., Cummiskey, T., Kumaresan, A., & Bose, S. (2026) · Critical Care Explorations · doi:10.1097/cce.0000000000001434
Astrup, K., Holm, A., Nedergaard, H. K., Rolving, N., & Dreyer, P. (2026) · Nursing in Critical Care · doi:10.1111/nicc.70544
Li, P. W. C., Tong, C. K., Lai, P. C. K., Ng, P. Y., Chan, S. C. S., Ho, M., & Yu, D. S. F. (2026) · Nursing in Critical Care · doi:10.1111/nicc.70548
Chronic Critical Illness and Post-intensive Care Syndrome
Darden, D. B., Laquian, L. F. P., Efron, P. A., & Taylor, J. (2026) · Springer eBooks · doi:10.1007/978-3-032-22660-0_50
Rolfsen, M. L., Murphy, T. J., Birdrow, C. I., Chandrasekhar, R., Mastalerz, N., Wurtz, M. J., Lee, J., Thompson, J., Mart, M. F., Rivera, E. L., et al. (2026) · BMJ Open · doi:10.1136/bmjopen-2026-118830
Self-citationChung, C. R., Yeo, H. J., Do, J. G., Na, Y., Choi, E., Kang, J., Kwon, J., Kim, H. J., Park, J., Lee, H., et al. (2026) · Acute and Critical Care · doi:10.4266/acc.006630
Besnier, E., & Vardon, F. (2026) · EMC - Anestesia-Rianimazione · doi:10.1016/s1283-0771(26)52350-8
Síndrome post-cuidados intensivos
Besnier, E., & Vardon, F. (2026) · EMC - Anestesia-Reanimación · doi:10.1016/s1280-4703(26)52200-x
Metadata
- Authors
- Jackson, J. C., Ely, E. W., Morey, M. C., Anderson, V. M., Denne, L. B., Clune, J., Siebert, C. S., Archer, K. R., Torres, R., Janz, D., Schiro, E., Jones, J., Shintani, A. K., Levine, B., Pun, B. T., Thompson, J., Brummel, N. E., & Hoenig, H.
- Affiliations
- Vanderbilt University Medical Center (US)
- Duke University (US)
- ORCID
- Venue
- Critical Care Medicine
- Published
- 2012-04
- Volume
- 40
- Issue
- 4
- Pages
- 1088-1097
- ISSN
- 0090-3493 (ISSN-L)
- PMC
- PMC3755871
- OpenAlex
- W2022518136
- Semantic Scholar
- 5006c650bfa9cf34e2da5f3148ecd9d0817491bd
- Cited by
- 318
- References
- 71
- Citations by year
- 2026: 22 · 2025: 21 · 2024: 24 · 2023: 14 · 2022: 17 · 2021: 26 · 2020: 23 · 2019: 24 · 2018: 19 · 2017: 24 · 2016: 30 · 2015: 20 · 2014: 16 · 2013: 21 · 2012: 16
- FWCI
- 13.66
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service (RRDE3386R)
- National Institute on Aging (AG028716, K23AG031322, R01AG027472, P30AG028716)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Medical Practices and Rehabilitation
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Keywords
- intensive care unit survivors, cognitive rehabilitation, physical rehabilitation, functional rehabilitation, telerehabilitation, home-based rehabilitation, executive function, cognitive impairment, functional disability, social workers, telemedicine, multidisciplinary care, post-intensive care syndrome, feasibility
- MeSH terms
- Activities of Daily Living, Adult, Aged, Cognition Disorders, Critical Care, Exercise Therapy, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Occupational Therapy, Pilot Projects, Critical Illness, Treatment Outcome, Telemedicine, Survivors
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