Outcomes of Statin Myopathy After Statin Withdrawal
Abstract
Objective To study the outcomes of statin myopathy after statin withdrawal. Methods Sixty-nine patients with mild statin myopathy were studied by chart review. Results Mean age at presentation was 62.1 years. Forty-nine (71.0%) of the 69 patients were men. Mean duration of follow-up after statin withdrawal was 18.2 months. Muscle symptoms improved in 9 (13.0%) and completely resolved in 50 (72.5%) patients. Thirteen (18.8%)/69 patients had symptoms lingered beyond 14 months. Creatine kinase (CK) levels were elevated in 52 (75.4%)/69 patients at initial presentation and returned to normal in 11 (21.3%)/52 patients at follow-up. Symptom improvement was not influenced by the initial presence of weakness, CK elevation, or myopathic changes on electromyography or muscle biopsy. Conclusions Muscle symptoms can linger beyond 14 months, and it is difficult to predict which patients will have a prolonged recovery course. CK normalization often lags behind symptom improvement, and this should not be the only indication for muscle biopsy.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Observational studies have found that statin-related symptoms can take several months to develop.
“observational studies have found it can take several months for statin-related symptoms to develop”
From Intolerance upon statin rechallenge: A systematic review and meta-analysis of randomized controlled trials (2023) · cites this paper as [25]
Observational studies have found that statin-related symptoms can take several months to resolve.
“and again several months for them to resolve [24–26].”
From Intolerance upon statin rechallenge: A systematic review and meta-analysis of randomized controlled trials (2023) · cites this paper as [25]
No citation lists for this paper
No citation lists for this paper yet — checked again daily.
References 12 · Cited by 21
- Authors
- Armour, R., & Zhou, L.
- Affiliations
- Cleveland Clinic (US)
- ORCID
- Zhou, Lan
- Venue
- Journal of Clinical Neuromuscular Disease
- Published
- 2013-03
- Volume
- 14
- Issue
- 3
- Pages
- 103-109
- ISSN
- 1522-0443 (ISSN-L)
- OpenAlex
- W2090664262
- Cited by
- 21
- References
- 12
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 5 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 2
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Neuromuscular Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Epidemiology › Inflammatory Myopathies and Dermatomyositis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- statin-induced myopathy, statin withdrawal, muscle symptoms, creatine kinase, symptom resolution, recovery time course, muscle biopsy, electromyography, prolonged recovery
- MeSH terms
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Muscular Diseases, Muscle, Skeletal, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Dyslipidemias
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
