The DOI matches its Crossref record; 65 of the 66 references it cites were found in a registry or an index.
Approach to the so-called “Invisible Dermatosis”: When Subtle Histopathological Findings Guide Diagnosis
Abstract
ABSTRACT: Invisible dermatosis is a concept that can be applied either to clinical or histopathological findings. We will focus on the dermatopathological aspect of this invisible dermatosis that can be seen as dermatosis with subtle histopathological findings that are mandatory to known to stablish the diagnosis. With a proper approach facing in depth the different skin layers from stratum corneum to subcutaneous tissue combined with some especial stains, special investigations and mostly a proper clinicopathological correlation, the problem of missing out a diagnosis can be decreased. We will review the general aspects for diagnosis and the peculiar findings of an in-depth review of them because it is important to note that minor changes on a skin biopsy do not mean it is disease free. We will review classic clues, we will add some new useful ones, and we will also provide a guide on the special stains helpful, such as periodic acid-Schiff when facing fungi, orcein-Giemsa and van Gieson when altered elastic fibers are suspected, or Pearl and Masson Fontana when an altered skin pigmentation is suspected.
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In the citing paper
“To date, only a single recent study has investigated the use of DL in identifying fungal organisms in skin tissue sections [26].”
From Artificial Intelligence in the Histopathological Assessment of Non-Neoplastic Skin Disorders: A Narrative Review with Future Perspectives (2025) · cites this paper as [26]
In the citing paper
“Additionally, the dependence on special stains meant there was less potential of shortening turnaround times and reducing the use of resources [26,27,28,29,30,31,32].”
From Artificial Intelligence in the Histopathological Assessment of Non-Neoplastic Skin Disorders: A Narrative Review with Future Perspectives (2025) · cites this paper as [26]
In the citing paper
“Sensitivity, specificity, and F1 score (indicating precision) were higher for GMS (0.93, 0.99, and 0.95, respectively) compared to PAS (0.8, 0.97, and 0.78, respectively) [26].”
From Artificial Intelligence in the Histopathological Assessment of Non-Neoplastic Skin Disorders: A Narrative Review with Future Perspectives (2025) · cites this paper as [26]
In the citing paper
“The algorithm demonstrated overall low false-positive and false-negative results.”
From Artificial Intelligence in the Histopathological Assessment of Non-Neoplastic Skin Disorders: A Narrative Review with Future Perspectives (2025) · cites this paper as [26]
In the citing paper
“These cases usually require careful histological examination and the use of special stains, such as periodic acid–Schiff (PAS) and Gomori methenamine silver (GMS) [24,25,26].”
From Artificial Intelligence in the Histopathological Assessment of Non-Neoplastic Skin Disorders: A Narrative Review with Future Perspectives (2025) · cites this paper as [26]
Citations
Cites
Defining early mycosis fungoides
Pimpinelli, N., Olsen, E. A., Santucci, M., Vonderheid, E., Haeffner, A. C., Stevens, S., Burg, G., Cerroni, L., Dreno, B., Glusac, E., et al. (2005) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2005.08.057 · Cited by 550
Presence or Absence of Melanocytes in Vitiligo Lesions: An Immunohistochemical Investigation
Poole, I. C. L., van den Wijngaard, R. M., Westerhof, W., Dutrieux, R. P., & Das, P. K. (1993) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12476645 · Cited by 214
Histopathologic Features of Early (Patch) Lesions of Mycosis Fungoides
Massone, C., Kodama, K., Kerl, H., & Cerroni, L. (2005) · The American Journal of Surgical Pathology · doi:10.1097/01.pas.0000153121.57515.c6 · Cited by 203
Cutaneous reactions at sites of herpes zoster scars: an expanded spectrum
Requena, Kutzner, Escalonilla, Ortiz, Schaller, & Rohwedder (1998) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1998.02045.x · Cited by 157
Skin biopsy for the diagnosis of peripheral neuropathy
Lauria, G., Lombardi, R., Camozzi, F., & Devigili, G. (2008) · Histopathology · doi:10.1111/j.1365-2559.2008.03096.x · Cited by 139
Pérez, A., Rütten, A., Gold, R., Urbina, F., Misad, C., Izquierdo, M. J. M. E., Requena, C., Aliaga, A., Kutzner, H., & Requena, L. (2002) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2002.120466 · Cited by 133
Cutaneous Graft-versus-Host Disease: A Guide for the Dermatologist
Häusermann, P., Walter, R. B., Halter, J. P., Biedermann, B. C., Tichelli, A., Itin, P. H., & Gratwohl, A. A. (2008) · Dermatology · doi:10.1159/000113941 · Cited by 118
Severe generalized argyria secondary to ingestion of colloidal silver protein
White, J. M. L., Powell, A. M., Brady, K., & Russell‐Jones, R. (2003) · Clinical and Experimental Dermatology · doi:10.1046/j.1365-2230.2003.01214.x · Cited by 114
The sunburn cell: Regulation of death and survival of the keratinocyte
Laethem, A. V., Claerhout, S., Garmyn, M., & Agostinis, P. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.02.015 · Cited by 111
Dermatomyositis: A Clinicopathological Study of 40 Patients
Smith, E. S. C., Hallman, J. R., DeLuca, A. M., Goldenberg, G., Jorizzo, J. L., & Sangüeza, O. P. (2009) · American Journal of Dermatopathology · doi:10.1097/dad.0b013e31818520e1 · Cited by 91
Cited by
Della Mura, M., Sorino, J., Colagrande, A., Daruish, M., Ingravallo, G., Massaro, A., Cazzato, G., Lupo, C., Casatta, N., Ribatti, D., et al. (2025) · Medical Sciences · doi:10.3390/medsci13020070 · Cited by 6
Müller, C. S. L., Hansen, T., & Renzelmann, C. (2025) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.15985 · Cited by 5
Concomitância da hanseníase virchowiana e carcinoma de células escamosas
Hatanaka, H., Dornelas, B. D. C., Girardi, P. D. S., Sena, C. O., Rocha, M. C., & Goulart, I. M. B. (2024) · Hansenologia Internationallis hanseníase e outras doenças infecciosas · doi:10.47878/hi.2024.v49.40198
Lyme Borreliosis Incognito—Expanding the Spectrum of Invisible Dermatoses
Pruessmann, W., Huebner, G., & Rosé, C. (2025) · American Journal of Dermatopathology · doi:10.1097/dad.0000000000003055
Hiding in plain sight: the ‘normal skin/invisible dermatoses’ differential diagnosis
Maniam, G. B., & Diwan, A. H. (2025) · Diagnostic histopathology · doi:10.1016/j.mpdhp.2025.12.002
Metadata
- Authors
- Llamas-Velasco, M., Pérez-Muñoz, N., Rozas-Muñoz, E., Ballester, R., Posada, R., & Figueras, M. F.
- Affiliations
- Faculty, Department of Dermatology, Hospital Universitario de La Princesa, Madrid, Spain;
- Faculty, Department of Pathology, Hospital Universitari General de Catalunya-Quirónsalud, Sant Cugat del Vallès, Barcelona, Spain;
- Dermatology Department, Hospital San Pablo, Coquimbo, Chile.
- Hospital General de Catalunya (ES)
- ORCID
- Llamas-Velasco, Mar
- Venue
- The American Journal of Dermatopathology
- Published
- 2023-10-02
- Volume
- 45
- Issue
- 12
- Pages
- 801-811
- ISSN
- 0193-1091 (ISSN-L)
- OpenAlex
- W4388826455
- Cited by
- 9
- References
- 66
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 1
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Dermatopathology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Medicine and Dermatology Studies History
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Cancer and Skin Lesions
- Keywords
- dermatopathology, skin biopsy, histopathological diagnosis, clinicopathological correlation, special stains, periodic acid-Schiff reaction, fungal infection, stratum corneum, subcutaneous tissue
- MeSH terms
- Biopsy, Epidermis, Fungi, Humans, Skin, Skin Diseases
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- CoChat. (2026). Citation check: Approach to the so-called “Invisible Dermatosis”: When Subtle Histopathological Findings Guide Diagnosis. https://app.cochat.ai/papers/10.1097/dad.0000000000002563
- The paper
- Llamas-Velasco, M., Pérez-Muñoz, N., Rozas-Muñoz, E., Ballester, R., Posada, R., & Figueras, M. F. (2023). Approach to the so-called “Invisible Dermatosis”: When Subtle Histopathological Findings Guide Diagnosis. The American Journal of Dermatopathology. https://doi.org/10.1097/dad.0000000000002563
