Baseline mental health and psychosocial functioning of transgender adolescents seeking gender-affirming hormone therapy
Abstract
Objective Research suggests that adolescents seeking gender-affirming hormone therapy experience elevated rates of depression, anxiety, and difficulties with peer relationships. Less is known regarding more specific aspects of mental health and psychosocial functioning. Furthermore, few studies have explored variations in mental health and psychosocial functioning by age, gender, degree of physical dysphoria, and informant type (adolescent, mother, and father). Method Participants are adolescents (n = 149) and parents/guardians (n = 247) who presented to a multidisciplinary gender clinic in Dallas, TX for an initial assessment before initiation of gender-affirming hormone therapy. Adolescents completed the Youth Self-Report (YSR) and the Body Image Scale (a measure of physical dysphoria), and parents/guardians completed the Child Behavior Checklist (CBCL). Results Approximately half of participants reported clinically significant difficulties with internalizing symptoms and psychosocial functioning (particularly engagement in activities), with approximately one-third indicating significant difficulties with depression, anxiety, obsessive compulsive, and posttraumatic stress symptoms. Parents reported fewer symptoms than adolescents across several subscales, but differences were generally small. By contrast, gender differences were found across all internalizing subscales and were generally large. Age and body dissatisfaction were not independently associated with broadband me…
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These symptoms are exacerbated in TNB adolescents.
“which are exacerbated TNB adolescents (12).”
From Puberty Blocker, Leuprolide, Reduces Sex Differences in Rough-and-Tumble Play and Anxiety-like Behavior in Juvenile Rats (2024) · cites this paper as [12]
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Oliveira, G. D. F., Nguyen, A. T., Carreras-Simons, L., Niepsuj, T., Gadelhak, S. H., Johnson, A. K., Abdalla, A., Lev, E., Torres Román, S. G., Fuchs, S. N., et al. (2024) · Endocrinology · doi:10.1210/endocr/bqae046 · Cited by 5 · see citing works
- Authors
- Kuper, L. E., Mathews, S., & Lau, M.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Texas Tech University (US)
- Corresponding author
- Kuper, Laura E.
- Venue
- Journal of Developmental & Behavioral Pediatrics
- Published
- 2019-10
- Volume
- 40
- Issue
- 8
- Pages
- 589-596
- ISSN
- 0196-206X (ISSN-L)
- OpenAlex
- W2954795409
- Cited by
- 69
- References
- 2
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 19 · 2023: 16 · 2022: 12 · 2021: 7 · 2020: 3 · 2019: 1
- FWCI
- 7.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Developmental & Behavioral Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › LGBTQ Health, Identity, and Policy
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Health Sciences › Health Professions › Speech and Hearing › Adolescent and Pediatric Healthcare
- Keywords
- transgender youth, gender-affirming hormone therapy, mental health, psychosocial functioning, internalizing problems, depression, anxiety, obsessive-compulsive symptoms, posttraumatic stress symptoms, body image, gender differences, parent-adolescent discrepancies, gender clinics
- MeSH terms
- Gender Dysphoria, Adolescent, Adolescent Behavior, Behavioral Symptoms, Child, Female, Humans, Male, Stress Disorders, Post-Traumatic, Texas, Hormone Replacement Therapy, Sex Reassignment Procedures, Gender-Affirming Procedures, Transgender Persons, Social Skills
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