Systemic treatments for allergic contact dermatitis
Abstract
Allergic contact dermatitis is a common disease within the family of delayed-type hypersensitivity reactions. In more severe cases of allergic contact dermatitis, topical steroids may prove insufficient, and systemic therapeutic agents are often used. Even when systemic therapies such as cyclosporine lead to improvement, withdrawal of these agents is challenging and can lead to undesirable morbidities. Currently, there are no systemic treatments indicated for the treatment of widespread recalcitrant contact dermatitis. This review discusses the targets of in-use off-label systemic medications and potential therapeutics in the pipeline.
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These agents are used for severe ACD and typically are chosen as a last resort due to their immunosuppressive activity.
“These agents are used for severe ACD and typically are chosen as a last resort due to their immunosuppressive activity.”
From Dupilumab for Allergic Contact Dermatitis: An Overview of Its Use and Impact on Patch Testing. (2022) · cites this paper as [6]
Other systemic treatments for ACD include methotrexate, cyclosporine, mycophenolate mofetil, and azathioprine.
“Other systemic treatments for ACD include methotrexate, cyclosporine, mycophenolate mofetil, and azathioprine.6”
From Dupilumab for Allergic Contact Dermatitis: An Overview of Its Use and Impact on Patch Testing. (2022) · cites this paper as [6]
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Dupilumab for Allergic Contact Dermatitis: An Overview of Its Use and Impact on Patch Testing.
Johnson, H. (2022) · Current Psychiatry · doi:10.12788/cutis.0519 · Cited by 20 · see citing works
- Authors
- Sung, C. T., McGowan, M. A., Machler, B. C., & Jacob, S. E.
- Affiliations
- University of California, Riverside (US)
- Loma Linda University (US)
- New York University (US)
- ORCID
- Jacob, Sharon E.
- Venue
- Dermatitis®
- Publisher
- SAGE Publications
- Published
- 2019-02-01
- Volume
- 30
- Issue
- 1
- Pages
- 46-53
- ISSN
- 1710-3568 (ISSN-L)
- 2162-5220
- OpenAlex
- W2908893332
- Cited by
- 31
- References
- 0
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 5 · 2020: 3 · 2019: 1
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Dermatitis (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Miami
- Leonard M. Miller School of Medicine
- Topics
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Pharmacology › Drug-Induced Adverse Reactions
- Keywords
- allergic contact dermatitis, systemic therapy, cyclosporine, off-label drug use, delayed-type hypersensitivity, topical corticosteroids, new drugs
- MeSH terms
- Etanercept, Adalimumab, Infliximab, Adrenal Cortex Hormones, Anti-Inflammatory Agents, Non-Steroidal, Antibodies, Monoclonal, Azathioprine, Humans, Immunosuppressive Agents, Methotrexate, Mycophenolic Acid, Thalidomide, Tumor Necrosis Factor-alpha, Cyclosporine, Dermatitis, Allergic Contact, Off-Label Use, Antibodies, Monoclonal, Humanized
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