Polynucleotides in Skin Regeneration: Targeting the Adenosine A2A Receptor and Salvage Pathway
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PN has shown benefits for skin health, including improving skin texture and elasticity, and reducing wrinkle depth.
“In dermatology, PN, primarily derived from fish testes, has shown promising benefits for skin health, including improving skin texture and elasticity, and reducing wrinkle depth [26,27,28].”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [27]
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Kim, S. T. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17081024 · Cited by 18 · see citing works
- Authors
- Urso Pitassi, L. H., Pearson, K., Antônio de Assis, L., Biesman, B., Calomeni, M., Bay-Aguilera, S., & Wyles, S. P.
- Affiliations
- Division of Dermatology, Department of Medicine, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
- Mayo Clinic (US)
- Centro de Especialidades e Oftalmologia, Timóteo-Minas Gerais, Brazil
- Vanderbilt University Medical Center (US)
- Private Practice, Rio de Janeiro, Brazil
- Department of Dermatology, Nova Southeastern University College of Osteopathic Medicine, Fort Lauderdale, Florida
- Corresponding author
- Wyles, Saranya P.
- Venue
- Dermatologic Surgery
- Published
- 2024-10-09
- Volume
- 50
- Issue
- 11S
- Pages
- S131-S134
- ISSN
- 1076-0512 (ISSN-L)
- 1524-4725
- OpenAlex
- W4403947299
- Cited by
- 8
- References
- 0
- Citations by year
- 2026: 5 · 2025: 3
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Dermatologic Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Keywords
- polynucleotides, skin regeneration, adenosine A2A receptor, salvage pathway, adenosine, wound healing, gene therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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