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Cited by 323

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Long-term Exposure to Air Pollution and Cardiovascular Mortality: An Analysis of 22 European Cohorts

Open access
Beelen, Rob, Stafoggia, Massimo, Raaschou-Nielsen, Ole, Andersen, Zorana Jovanovic, Xun, Wei W., Katsouyanni, Klea, Dimakopoulou, Konstantina, Brunekreef, Bert, Weinmayr, Gudrun, Hoffmann, Barbara, Wolf, Kathrin, Samoli, Evangelia, Houthuijs, Danny, Nieuwenhuijsen, Mark, Oudin, Anna, Forsberg, Bertil, Olsson, David, Salomaa, Veikko, Lanki, Timo, Yli-Tuomi, Tarja, Oftedal, Bente, Aamodt, Geir, Nafstad, Per, De Faire, Ulf, Pedersen, Nancy L., Östenson, Claes-Göran, Fratiglioni, Laura, Penell, Johanna, Korek, Michal, Pyko, Andrei, Eriksen, Kirsten Thorup, Tjønneland, Anne, Becker, Thomas, Eeftens, Marloes, Bots, Michiel, Meliefste, Kees, Wang, Meng, Bueno-de-Mesquita, Bas, Sugiri, Dorothea, Krämer, Ursula, Heinrich, Joachim, de Hoogh, Kees, Key, Timothy, Peters, Annette, Cyrys, Josef, Concin, Hans, Nagel, Gabriele, Ineichen, Alex, Schaffner, Emmanuel, Probst-Hensch, Nicole, Dratva, Julia, Ducret-Stich, Regina, Vilier, Alice, Clavel-Chapelon, Françoise, Stempfelet, Morgane, Grioni, Sara, Krogh, Vittorio, Tsai, Ming-Yi, Marcon, Alessandro, Ricceri, Fulvio, Sacerdote, Carlotta, Galassi, Claudia, Migliore, Enrica, Ranzi, Andrea, Cesaroni, Giulia, Badaloni, Chiara, Forastiere, Francesco, Tamayo, Ibon, Amiano, Pilar, Dorronsoro, Miren, Katsoulis, Michail, Trichopoulou, Antonia, Vineis, Paolo, Hoek, Gerard·2014·Epidemiology

Abstract

BACKGROUND: Air pollution has been associated with cardiovascular mortality, but it remains unclear as to whether specific pollutants are related to specific cardiovascular causes of death. Within the multicenter European Study of Cohorts for Air Pollution Effects (ESCAPE), we investigated the associations of long-term exposure to several air pollutants with all cardiovascular disease (CVD) mortality, as well as with specific cardiovascular causes of death. METHODS: Data from 22 European cohort studies were used. Using a standardized protocol, study area-specific air pollution exposure at the residential address was characterized as annual average concentrations of the following: nitrogen oxides (NO2 and NOx); particles with diameters of less than 2.5 μm (PM2.5), less than 10 μm (PM10), and 10 μm to 2.5 μm (PMcoarse); PM2.5 absorbance estimated by land-use regression models; and traffic indicators. We applied cohort-specific Cox proportional hazards models using a standardized protocol. Random-effects meta-analysis was used to obtain pooled effect estimates. RESULTS: The total study population consisted of 367,383 participants, with 9994 deaths from CVD (including 4,992 from ischemic heart disease, 2264 from myocardial infarction, and 2484 from cerebrovascular disease). All hazard ratios were approximately 1.0, except for particle mass and cerebrovascular disease mortality; for PM2.5, the hazard ratio was 1.21 (95% confidence interval = 0.87-1.69) per 5 μg/m and for PM10, 1.22 (0.91-1.63) per 10 μg/m. CONCLUSION: In a joint analysis of data from 22 European cohorts, most hazard ratios for the association of air pollutants with mortality from overall CVD and with specific CVDs were approximately 1.0, with the exception of particulate mass and cerebrovascular disease mortality for which there was suggestive evidence for an association.

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Authors
Beelen, R., Stafoggia, M., Raaschou-Nielsen, O., Andersen, Z. J., Xun, W. W., Katsouyanni, K., Dimakopoulou, K., Brunekreef, B., Weinmayr, G., Hoffmann, B., Wolf, K., Samoli, E., Houthuijs, D., Nieuwenhuijsen, M., Oudin, A., Forsberg, B., Olsson, D., Salomaa, V., Lanki, T., Yli-Tuomi, T., Oftedal, B., Aamodt, G., Nafstad, P., De Faire, U., Pedersen, N. L., Östenson, C.-G., Fratiglioni, L., Penell, J., Korek, M., Pyko, A., Eriksen, K. T., Tjønneland, A., Becker, T., Eeftens, M., Bots, M., Meliefste, K., Wang, M., Bueno-de-Mesquita, B., Sugiri, D., Krämer, U., Heinrich, J., de Hoogh, K., Key, T., Peters, A., Cyrys, J., Concin, H., Nagel, G., Ineichen, A., Schaffner, E., Probst-Hensch, N., Dratva, J., Ducret-Stich, R., Vilier, A., Clavel-Chapelon, F., Stempfelet, M., Grioni, S., Krogh, V., Tsai, M.-Y., Marcon, A., Ricceri, F., Sacerdote, C., Galassi, C., Migliore, E., Ranzi, A., Cesaroni, G., Badaloni, C., Forastiere, F., Tamayo, I., Amiano, P., Dorronsoro, M., Katsoulis, M., Trichopoulou, A., Vineis, P., & Hoek, G.
Venue
Epidemiology
Published
2014-05
Volume
25
Issue
3
Pages
368-378
ISSN
1044-3983 (ISSN-L)
OpenAlex
W2137167968
Cited by
323
References
43
FWCI
16.38
Type
journal article
Language
en
Open access
green

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Beelen, R., Stafoggia, M., Raaschou-Nielsen, O., Andersen, Z. J., Xun, W. W., Katsouyanni, K., Dimakopoulou, K., Brunekreef, B., Weinmayr, G., Hoffmann, B., Wolf, K., Samoli, E., Houthuijs, D., Nieuwenhuijsen, M., Oudin, A., Forsberg, B., Olsson, D., Salomaa, V., Lanki, T., . . . Hoek, G. (2014). Long-term Exposure to Air Pollution and Cardiovascular Mortality: An Analysis of 22 European Cohorts. Epidemiology. https://doi.org/10.1097/ede.0000000000000076

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