The DOI matches its Crossref record; 209 of the 209 references it cites were found in a registry or an index.
Assessing the validity of current mouse genetic models of obsessive-compulsive disorder
Open accessAbstract
Obsessive-compulsive disorder (OCD) is a disorder characterized by unwanted and intrusive thoughts, images, or impulses and/or repetitive behavior. OCD is a major cause of disability; however, the genetic factors and pathophysiological mechanisms underlying this complex, heterogeneous disorder remain largely unknown. During the past decade, a number of putative mouse genetic models of OCD have been developed for the purpose of studying the neural mechanisms underlying this disorder and developing novel treatments. This review presents and evaluates these experimental preparations to date. Models using knockout or transgenic approaches, as well as those examining variation in genetically diverse populations, are evaluated and discussed.
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“OCD animal models have classically emphasized the presence of stereotyped and compulsive behaviors, although reliance on face validity may lead to discrepancies in the field since identical phenotypes can result from different underlying biological processes (for review see Wang et al, 2009) 81.”
From DISSECTING OCD CIRCUITS: FROM ANIMAL MODELS TO TARGETED TREATMENTS: Review: Dissecting OCD Circuits: Animals to Treatments (2015) · cites this paper as [81]
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Shmelkov, S. V., Hormigo, A., Jing, D., Proenca, C. C., Bath, K. G., Milde, T., Shmelkov, E., Kushner, J. S., Baljevic, M., Dincheva, I., et al. (2010) · Nature Medicine · doi:10.1038/nm.2125 · Cited by 361
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Metadata
- Authors
- Wang, L., Simpson, H. B., & Dulawa, S. C.
- Affiliations
- University of Chicago (US)
- New York State Psychiatric Institute (US)
- Corresponding author
- Dulawa, Stephanie C.
- Venue
- Behavioural Pharmacology
- Published
- 2009-03
- Volume
- 20
- Issue
- 2
- Pages
- 119-133
- ISSN
- 0955-8810 (ISSN-L)
- PMC
- PMC2762389
- OpenAlex
- W2016619143
- Cited by
- 50
- References
- 209
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2017: 3 · 2016: 2 · 2015: 6 · 2014: 3 · 2013: 5 · 2012: 4
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Behavioural Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health
- National Institute of Mental Health (K24MH091555, R24MH080022, K01MH071555, R01MH079424)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- obsessive-compulsive disorder, genetic mouse models, model validity, knockout mice, transgenic mice, genetic factors, neural mechanisms, animal models of psychiatric disorders
- MeSH terms
- Animals, Brain, Disease Models, Animal, Humans, Mice, Transgenic, Models, Genetic, Obsessive-Compulsive Disorder, Mice, Knockout, Mice
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