Sex differences in social interaction of methamphetamine-treated rats
Abstract
Our previous study showed that single injection of methamphetamine decreases social interaction (SI) in a dose-dependent manner that was further affected by stressful environment conditions. The aim of this study was to examine the effect of methamphetamine and its interaction with gonadal hormones on SI. Adult male and female rats were gonadectomized and assigned to testosterone-treated and oil-treated groups in male rats and estradiol-treated and oil-treated groups in female rats, respectively. Hormones were administered 30 min before each habituation in the open field. All four hormonal groups were further divided to control (without injection), saline (1 ml/kg saline injection), and methamphetamine (1 mg/kg) groups. Injections were applied 30 min before the SI test. The total duration and the total number of SI and nonsocial behavioral patterns were assessed. This study showed that an acute methamphetamine administration in a dose of 1 mg/kg decreased different types of SI in both sexes. In contrast, the same dose of methamphetamine increased locomotion and rearing behavior in male and female rats. The frequency and/or duration of SI (especially mutual sniffing and allogrooming) was lower in adult female rats relative to gonadectomized male rats, but locomotion was increased in female relative to male rats regardless of the presence or absence of gonadal hormones. In conclusion, this study is novel especially because it examines SI in both sexes in relation to the presenc…
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Male rats tend to spend more time interacting with an unfamiliar, same-sex conspecific than do females.
“male rats tend to spend more time interacting with an unfamiliar, same-sex conspecific than do females (Carrier and Kabbaj, 2012; Slamberová et al., 2011; Stack et al., 2010).”
From The effects of prenatal PCBs on adult social behavior in rats (2015) · cites this paper as Slamberová et al., 2011
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The effects of prenatal PCBs on adult social behavior in rats
Reilly, M. P., Weeks, C. D., Topper, V. Y., Thompson, L. M., Crews, D., & Gore, A. C. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.06.002 · Cited by 65 · see citing works
“Research has shown sex differences in these behaviors, as male rats tend to spend more time interacting with an unfamiliar, same-sex conspecific than do females (Carrier and Kabbaj, 2012; Slamberová et al., 2011; Stack et al., 2010).”
- Authors
- Šlamberová, R., Mikulecká, A., Pometlová, M., Schutová, B., Hrubá, L., & Deykun, K.
- Affiliations
- Charles University (CZ)
- Czech Academy of Sciences (CZ)
- Corresponding author
- Šlamberová, Romana
- ORCID
- Šlamberová, Romana
- Venue
- Behavioural Pharmacology
- Published
- 2011-10
- Volume
- 22
- Issue
- 7
- Pages
- 617-623
- ISSN
- 0955-8810 (ISSN-L)
- OpenAlex
- W2317547287
- Cited by
- 25
- References
- 0
- Citations by year
- 2025: 2 · 2024: 3 · 2021: 3 · 2020: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 7 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- ASEP (submittedVersion, public-domain)
- Funders
- Grantová Agentura České Republiky
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- methamphetamine, social interaction, sex differences, gonadal hormones, testosterone, estradiol, gonadectomy, locomotion, rearing behavior, allogrooming, acute drug administration
- MeSH terms
- Central Nervous System Stimulants, Animals, Behavior, Animal, Drug Interactions, Drug Evaluation, Preclinical, Estradiol, Female, Gonads, Interpersonal Relations, Locomotion, Male, Methamphetamine, Motor Activity, Sex Factors, Testosterone, Rats, Wistar, Models, Animal, Gonadal Hormones, Rats
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