The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Fibroblasts and Myofibroblasts: What Are We Talking About?
Open accessAbstract
Cardiac myocytes, although large enough to make up most of the heart volume, are only a minority of cells within the heart with fibroblasts and blood vessel components (endothelial and smooth muscle cells) making up the remainder of the heart. In recent years, there has been increasing interest in the nonmyocyte population within the heart. This is attributable, in part, to our increasing understanding of the biology of the nonmyocyte cell types and additionally it is the result of our awakening realization that these cells are not static but rather that they are dynamic in nature indicating that they play a more active role in cardiac function than previously imagined. Studies now show that fibroblasts are involved in formation of the extracellular matrix and they control the size of the extracellular matrix. Additionally, they participate in the repair process by differentiating into myofibroblasts, which are cells involved in the inflammatory response to injury. Myofibroblasts migrate to the sites of injury where they produce cytokines, thus enhancing the inflammatory response. This review discusses both structural and functional differences between the two cell types and examines the different roles of these two different cell types in the heart.
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Citations
Cites
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The myofibroblast in wound healing and fibrocontractive diseases
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Cardiac fibroblasts: At the heart of myocardial remodeling
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Infarct scar: a dynamic tissue
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Valkenburg, K. C., de Groot, A. E., & Pienta, K. J. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0007-1 · Cited by 1,084
Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease
Fan, D., Takawale, A., Lee, J., & Kassiri, Z. (2012) · Fibrogenesis & Tissue Repair · doi:10.1186/1755-1536-5-15 · Cited by 814
Tham, Y. K., Bernardo, B. C., Ooi, J. Y. Y., Weeks, K. L., & McMullen, J. R. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1477-x · Cited by 708
Cancer-Associated Fibroblasts Build and Secure the Tumor Microenvironment
Liu, T., Zhou, L., Li, D., Andl, T., & Zhang, Y. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00060 · Cited by 446
“…are different from normal fibroblasts in many aspects, including (1) ruffled membranes and a highly active endoplasmic reticulum (Baum and Duffy, 2011); (2) expression of alpha smooth muscle actin (α-SMA or ACTA2) and increased levels of vimentin (VIM) (Ronnov-Jessen and Petersen, 1993)…”
BackgroundMolecular mechanism involved in cyclophosphamide-induced cardiotoxicity: Old drug with a new vision
Iqubal, A., Iqubal, M. K., Sharma, S., Ansari, M. A., Najmi, A. K., Ali, S. M., Ali, J., & Haque, S. E. (2019) · Life Sciences · doi:10.1016/j.lfs.2018.12.018 · Cited by 328
Metadata
- Authors
- Baum, J., & Duffy, H. S.
- Venue
- Journal of Cardiovascular Pharmacology
- Published
- 2011-04
- Volume
- 57
- Issue
- 4
- Pages
- 376-379
- ISSN
- 0160-2446 (ISSN-L)
- OpenAlex
- W2020087937
- Cited by
- 481
- References
- 24
- FWCI
- 8.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Baum, J., & Duffy, H. S. (2011). Fibroblasts and Myofibroblasts: What Are We Talking About? Journal of Cardiovascular Pharmacology. https://doi.org/10.1097/fjc.0b013e3182116e39
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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