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Consanguineous marriages, pearls and perils: Geneva International Consanguinity Workshop Report
Open accessAbstract
Approximately 1.1 billion people currently live in countries where consanguineous marriages are customary, and among them one in every three marriages is between cousins. Opinions diverge between those warning of the possible health risks to offspring and others who highlight the social benefits of consanguineous marriages. A consanguinity study group of international experts and counselors met at the Geneva International Consanguinity Workshop from May 3, 2010, to May 7, 2010, to discuss the known and presumptive risks and benefits of close kin marriages and to identify important future areas for research on consanguinity. The group highlighted the importance of evidence-based counseling recommendations for consanguineous marriages and of undertaking both genomic and social research in defining the various influences and outcomes of consanguinity. Technological advances in rapid high-throughput genome sequencing and for the identification of copy number variants by comparative genomic hybridization offer a significant opportunity to identify genotype-phenotype correlations focusing on autozygosity, the hallmark of consanguinity. The ongoing strong preferential culture of close kin marriages in many societies, and among migrant communities in Western countries, merits an equivalently detailed assessment of the social and genetic benefits of consanguinity in future studies.
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“This will bias the results if, as seems plausible, consanguineous marriages tend to occur in families with a tradition of close-kin unions (Hussain and Bittles 2000; Hamamy et al. 2011).”
From An Estimate of the Average Number of Recessive Lethal Mutations Carried by Humans (2015) · cites this paper as Hamamy et al. 2011
In the citing paper
“This prediction agrees well with the estimated 3.5 -4.4% increased risk for prereproductive mortality and 1.7 -2.8% increased incidence of congenital anomalies in children of first cousins above the general population risk (Hamamy et al. 2011).”
From An Estimate of the Average Number of Recessive Lethal Mutations Carried by Humans (2015) · cites this paper as Hamamy et al. 2011
In the citing paper
“Over the past centuries, consanguineous marriages were a common practice, and the custom remains prevalent in many countries (Bittles and Black 2010a; Hamamy et al. 2011).”
From An Estimate of the Average Number of Recessive Lethal Mutations Carried by Humans (2015) · cites this paper as Hamamy et al. 2011
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Metadata
- Authors
- Hamamy, H., Antonarakis, S. E., Cavalli-Sforza, L. L., Temtamy, S., Romeo, G., Ten Kate, L. P., Bennett, R. L., Shaw, A., Megarbane, A., van Duijn, C., Bathija, H., Fokstuen, S., Engel, E., Zlotogora, J., Dermitzakis, E., Bottani, A., Dahoun, S., Morris, M. A., Arsenault, S., Aglan, M. S., Ajaz, M., Alkalamchi, A., Alnaqeb, D., Alwasiyah, M. K., Anwer, N., Awwad, R., Bonnefin, M., Peter Corry, M. D., Gwanmesia, L., Karbani, G. A., Mostafavi, M., Pippucci, T., Ranza-Boscardin, E., Reversade, B., Sharif, S. M., Teeuw, M. E., & Bittles, A. H.
- Affiliations
- University of Geneva (CH)
- University of Pavia (IT)
- National Research Centre (EG)
- University of Bologna (IT)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- University of Washington Medical Center (US)
- University of Oxford (GB)
- Erasmus MC (NL)
- World Health Organization (CH)
- University Hospital of Geneva (CH)
- Génome Québec (CA)
- University of Bedfordshire (GB)
- Ministry of Health (IQ)
- King Saud University (SA)
- Baghdad Medical City (IQ)
- Hadassah Medical Center (IL)
- King's College London (GB)
- Leeds Teaching Hospitals NHS Trust (GB)
- IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
- Agency for Science, Technology and Research (SG)
- Chapel Allerton Hospital (GB)
- Amsterdam Public Health (NL)
- Edith Cowan University (AU)
- Corresponding author
- Hamamy, Hanan
- ORCID
- Venue
- Genetics in Medicine
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 13
- Issue
- 9
- Pages
- 841-847
- ISSN
- 1098-3600 (ISSN-L)
- OpenAlex
- W2062921444
- Cited by
- 345
- References
- 51
- Citations by year
- 2026: 22 · 2025: 28 · 2024: 27 · 2023: 28 · 2022: 18 · 2021: 31 · 2020: 25 · 2019: 23 · 2018: 23 · 2017: 17 · 2016: 24 · 2015: 21 · 2014: 30 · 2013: 11 · 2012: 14
- FWCI
- 61.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Genetics in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion)
- Murdoch University Research Portal (submittedVersion)
- Australasian Journal of Paramedicine (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Topics
- Social Sciences › Sociology and Political Science › Marriage and Family Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomics and Rare Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- consanguineous marriage, cousin marriage, autozygosity, inbreeding depression, genetic counseling, genotype-phenotype correlation, copy number variation, immigrant communities
- MeSH terms
- Consanguinity, Disease, Female, Humans, Male, Marriage, Quantitative Trait, Heritable, Genetic Research, DNA Copy Number Variations
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