The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Effects of ultralow topical estriol dose on vaginal health and quality of life in postmenopausal women who underwent surgical treatment for pelvic organ prolapse
Open accessAbstract
Objective: To evaluate the efficacy of low concentrations of vaginal estriol gel in postmenopausal women with pelvic static disorders before and after vaginal surgical treatment, assessing vaginal health, sexual function, and quality of life (QoL). Methods: Women affected by genital prolapse were enrolled. Vaginal health, QoL, and sexual function were investigated at baseline (T0), before surgery (T1), and 13 weeks after surgery (T2). At baseline, participants were randomized 1:1. Women in group A (38 women) were treated daily with vaginal gel containing 50 μg estriol for 12 weeks and women in group B (37 women) did not receive any estrogen treatment. After this period and before surgery, a first examination was carried out (T1). One week after surgical treatment, group A underwent randomization 1:1 to group A1 repeating estriol vaginal gel for 12 weeks, and group A2 discontinuing the estrogen treatment. The second follow-up examination (T2) was performed at the 13th week after surgery. Results: All aspects of vaginal health improved in group A on estriol before surgery with respect to baseline (P < 0.001). After surgery, 17 participants of group A1, 16 of group A2, and 30 of group B completed the study. Group A1 (on estriol plus surgery) further improved with respect to the presurgery estriol treatment (P < 0.01). Moreover, group A2 (T2) experienced a worsening of vaginal health versus intragroup presurgery estriol treatment (P < 0.01), and versus intergroup surgical estriol treatment (P < 0.05). QoL improved in women only after surgery, with (P < 0.01) or without (P < 0.05) estriol treatment. Finally, the sexual function of participants on estriol before surgery did not change. On the contrary, it improved after surgery in both participants on estriol (P < 0.001) and without estriol (P < 0.01). Moreover, surgical estriol participants had a better score than surgical no-estriol participants (P < 0.05). Conclusions: Estriol vaginal gel (0.005%) administration significantly improved the vaginal health of natural postmenopausal women before and after vaginal surgery. Both sexual health and QoL also significantly improved after surgery.
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“In other studies, significant benefit for vaginal health has been demonstrated using estriol gel [96]”
From Endometrial Intracrinology: Oestrogens, Androgens and Endometrial Disorders (2018) · cites this paper as [96]
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The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction
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Delorme, E. (2001) · PubMed · Cited by 1,129
A short form of the Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ-12)
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The Factor Structure of the SF-36 Health Survey in 10 Countries
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Management of symptomatic vulvovaginal atrophy
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Vitale, S. G., Caruso, S., Rapisarda, A. M. C., Cianci, S., & Cianci, A. (2018) · Menopause Review/Przegląd Menopauzalny · doi:10.5114/pm.2018.73791 · Cited by 77
Self-citationUrinary incontinence in postmenopausal women – causes, symptoms, treatment
Kołodyńska, G., Zalewski, M., & Roźek-Piechura, K. (2019) · Menopause Review/Przegląd Menopauzalny · doi:10.5114/pm.2019.84157 · Cited by 76
Endometrial Intracrinology: Oestrogens, Androgens and Endometrial Disorders
Gibson, D. A., Simitsidellis, I., Collins, F., & Saunders, P. T. K. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103276 · Cited by 70
“In other studies, significant benefit for vaginal health has been demonstrated using estriol gel [96]: these data have collectively provided powerful evidence for intracrine steroid modulation playing a key role in regulation of the vaginal microenvironment, which can be harnessed for therapeutic benefit after ovarian…”
BackgroundNovelties of ultrasound imaging for endometrial cancer preoperative workup
Capozzi, V. A., Rosati, A., Rumolo, V., Ferrari, F. G., Gullo, G., Karaman, E., Karaaslan, O., & HACIOĞLU, L. (2021) · Minerva Medica · doi:10.23736/s0026-4806.20.07125-6 · Cited by 44
Metadata
- Authors
- Caruso, S., Cianci, S., Vitale, S. G., Matarazzo, M. G., Amore, F. F., & Cianci, A.
- Affiliations
- University of Catania (IT)
- Department of General Surgery and Medical Surgical Specialties, Gynecological Clinic
- University of Messina (IT)
- Corresponding author
- Caruso, Salvatore
- ORCID
- Venue
- Menopause
- Published
- 2017-08
- Volume
- 24
- Issue
- 8
- Pages
- 900-907
- ISSN
- 1072-3714 (ISSN-L)
- 1530-0374
- OpenAlex
- W2599758693
- Cited by
- 50
- References
- 34
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 7 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 14 · 2018: 11
- FWCI
- 6.06
- Type
- journal article
- Language
- en
- Open access
- green
- journals.lww.com
- Licence
- cc-by-nc-nd
- Locations
- Menopause The Journal of The North American Menopause Society (publishedVersion)
- PubMed (publishedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion, cc-by-nc-nd)
- Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Urology › Pelvic floor disorders treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Keywords
- postmenopausal women, pelvic organ prolapse, vaginal health, quality of life, sexual function, vaginal surgery, low-dose estrogen therapy, menopause, vaginal atrophy, postoperative care, hormone replacement therapy, randomized controlled trials
- MeSH terms
- Atrophy, Estriol, Female, Humans, Interviews as Topic, Middle Aged, Postoperative Period, Quality of Life, Surveys and Questionnaires, Vagina, Vaginal Creams, Foams, and Jellies, Vaginal Diseases, Treatment Outcome, Postmenopause, Pelvic Organ Prolapse
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