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Effectiveness of group and self-help cognitive behavior therapy in reducing problematic menopausal hot flushes and night sweats (MENOS 2): a randomized controlled trial
Abstract
OBJECTIVE: The aim of this study was to examine the effectiveness of group cognitive behavioral therapy (CBT) and guided self-help CBT in reducing hot flush and night sweat (HF/NS) problem rating at 6 and 26 weeks after randomization. METHODS: This was a randomized control trial of 140 women having 10 or more problematic HF/NS a week for at least a month. The primary outcome was HF/NS problem rating (1-10) at 6 weeks after randomization. Secondary outcomes were physiologically measured HF/NS at 6 weeks; HF/NS problem rating at 6 weeks; and frequency, mood (Women's Health Questionnaire), and health-related quality of life (General Health Survey Short Form-36) at 6 and 26 weeks. Intention-to-treat analysis was used, and between-group differences were estimated using linear mixed models. RESULTS: Baseline mean (SD) HF/NS weekly frequency was 63.15 (49.24), and problem rating was 5.87 (2.28). Group and self-help CBT both significantly reduced HF/NS problem rating at 6 weeks-group CBT versus no treatment control (NTC; adjusted mean difference, 2.12; 95% CI, 1.36-2.88; P < 0.001) and self-help CBT versus NTC (adjusted mean difference, 2.08; 95% CI, 1.29-2.86; P < 0.001)-and at 26 weeks-group CBT versus NTC (adjusted mean difference, 1.33; 95% CI, 0.54-2.13; P = 0.001) and self-help CBT versus NTC (adjusted mean difference, 1.19; 95% CI, 0.36-2.02; P = 0.005). Group and self-help CBT significantly reduced night sweat frequency at 6 and 26 weeks. There were improvements in mood and quality of life at 6 weeks and improved emotional and physical functioning for group CBT at 26 weeks. CONCLUSIONS: These results suggest that CBT delivered in group or self-help format is an effective treatment option for women during the menopause transition and postmenopause with problematic HF/NS.
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“Three studies (Ayers et al., 2012; Kalmbach et al., 2019; Mann et al., 2012) found evidence for the effectiveness of CBT on the outcomes of the 36 Item Short Form Health Survey (SF-36, Ware & Sherbourne, 1992).”
From The effectiveness of psychosocial interventions on non-physiological symptoms of menopause: A systematic review and meta-analysis (2024) · cites this paper as Ayers et al., 2012
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Karvonen-Gutierrez, C. A., Gold, E. B., Harlow, S. D., Avis, N. E., Waetjen, L. E., Kravitz, H. M., Cauley, J. A., & Greendale, G. A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-45863-7.00035-4
Psychosomatic Presentation of Menopause
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Metadata
- Authors
- Ayers, B., Smith, M., Hellier, J., Mann, E., & Hunter, M. S.
- Affiliations
- King's College London (GB)
- Corresponding author
- Hunter, Myra S.
- Venue
- Menopause
- Published
- 2012-07
- Volume
- 19
- Issue
- 7
- Pages
- 749-759
- ISSN
- 1072-3714 (ISSN-L)
- OpenAlex
- W2036614660
- Cited by
- 207
- References
- 66
- Citations by year
- 2026: 18 · 2025: 20 · 2024: 13 · 2023: 12 · 2022: 9 · 2021: 14 · 2020: 9 · 2019: 21 · 2018: 14 · 2017: 15 · 2016: 12 · 2015: 8 · 2014: 12 · 2013: 18 · 2012: 11
- FWCI
- 12.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Menopause The Journal of The North American Menopause Society (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- menopausal hot flushes, night sweats, cognitive behavioral therapy, group therapy, self-help intervention, menopause, postmenopause, mood, health-related quality of life, treatment effectiveness, Women's Health Questionnaire, SF-36, women's health services, emotional functioning, physical function
- MeSH terms
- Affect, Female, Humans, Hyperhidrosis, Menopause, Middle Aged, Psychotherapy, Group, Quality of Life, Surveys and Questionnaires, Self Care, Cognitive Behavioral Therapy, Treatment Outcome, Hot Flashes
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