The DOI matches its Crossref record; 27 of the 29 references it cites were found in a registry or an index.
Healthy Vascular Aging Is Associated With Higher Cardiorespiratory Fitness
Abstract
Background: Healthy vascular aging (HVA) and cardiorespiratory fitness (CRF) are each independently associated with lower cardiovascular disease-related mortality. It is unknown, however, whether the CRF-related reductions in cardiovascular disease risk are related to HVA. We hypothesized that HVA would be associated with higher CRF in men and women from the B all State A dult Fitness L ongitudinal L ifestyle ST udy (BALL ST). Methods: Apparently healthy men and women ≥50 yr of age from the BALL ST cohort (n = 101) who underwent a maximal cardiopulmonary exercise test to assess CRF (V˙O 2peak) were included in the study. Participants were divided into either HVA, defined as brachial systolic blood pressure <140/90 mm Hg without taking medications and carotid-femoral pulse wave velocity <7.6 m/sec, or no HVA for subjects with SBP >140/90 mm Hg and/or PWV >7.6 m/sec. Results: Participants with HVA had a higher age- and sex-adjusted CRF percentile (62 ± 5 vs 47 ± 3, P < .05), with women having a greater prevalence of HVA than men (36% vs 15%, P < .05). Both carotid-femoral pulse wave velocity (r =−0.27, P < .05) and brachial systolic blood pressure (r =−0.23, P < .05) were independently and inversely associated with CRF for the entire cohort. Men and women with HVA were younger having a lower body fat percentage and higher low-density lipoprotein cholesterol (P < .05, all). Conclusions: These data demonstrate that HVA is associated with higher CRF, which may partially explain the preventative cardioprotective effects of CRF.
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“From a physiological standpoint, low cardiorespiratory fitness is associated with impaired vascular structure and function (36,57).”
From Cardiorespiratory Fitness, Workload, and the Blood Pressure Response to Exercise Testing (2022) · cites this paper as [36]
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Cites
Exercise capacity and mortality among men referred for exercise testing
Myers, J., Prakash, M., Froelicher, V., Do, D., Partington, S., & Atwood, J. E. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011858 · Cited by 4,114
Physical Fitness and All-Cause Mortality: A Prospective Study of Healthy Men and Women
Blair, S. N. (1989) · JAMA · doi:10.1001/jama.1989.03430170057028 · Cited by 2,658
Ross, R., Blair, S. N., Arena, R., Church, T. S., Després, J.-P., Franklin, B. A., Haskell, W. L., Kaminsky, L. A., Levine, B. D., Lavie, C. J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000461 · Cited by 2,486
Self-citationArterial Stiffness and Cardiovascular Events: The Framingham Heart Study
Mitchell, G. F., Hwang, S.-J., Vasan, R. S., Larson, M. G., Pencina, M. J., Hamburg, N. M., Vita, J. A., Levy, D., & Benjamin, E. J. (2010) · Circulation · doi:10.1161/circulationaha.109.886655 · Cited by 2,225
Aortic Pulse Wave Velocity Improves Cardiovascular Event Prediction
Ben-Shlomo, Y., Spears, M., Boustred, C., May, M., Anderson, S. G., Benjamin, E. J., Boutouyrie, P., Cameron, J., Chen, C.-H., Cruickshank, J. K., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.09.063 · Cited by 1,835
Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises
Lakatta, E. G., & Levy, D. A. (2003) · Circulation · doi:10.1161/01.cir.0000048893.62841.f7 · Cited by 1,257
Sutton-Tyrrell, K., Najjar, S. S., Boudreau, R. M., Venkitachalam, L., Kupelian, V. A., Simonsick, E. M., Havlik, R. J., Lakatta, E. G., Spurgeon, H. A., Kritchevsky, S. B., et al. (2005) · Circulation · doi:10.1161/circulationaha.104.483628 · Cited by 1,250
Aging, Habitual Exercise, and Dynamic Arterial Compliance
Tanaka, H., Dinenno, F. A., Monahan, K. D., Clevenger, C. M., DeSouza, C. A., & Seals, D. R. (2000) · Circulation · doi:10.1161/01.cir.102.11.1270 · Cited by 1,116
Vascular Smooth Muscle Cells and Arterial Stiffening: Relevance in Development, Aging, and Disease
Lacolley, P. J., Regnault, V., Segers, P., & Laurent, S. (2017) · Physiological Reviews · doi:10.1152/physrev.00003.2017 · Cited by 763
Arterial Aging: Is It an Immutable Cardiovascular Risk Factor?
Najjar, S. S., Scuteri, A., & Lakatta, E. G. (2005) · Hypertension · doi:10.1161/01.hyp.0000177474.06749.98 · Cited by 640
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Making the Case to Measure and Improve Cardiorespiratory Fitness in Routine Clinical Practice
Lavie, C. J., Arena, R. A., & Kaminsky, L. A. (2022) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2022.04.011 · Cited by 63
Self-citationCardiorespiratory Fitness, Workload, and the Blood Pressure Response to Exercise Testing
Schultz, M. G., La Gerche, A., & Sharman, J. E. (2022) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000276 · Cited by 36
“From a physiological standpoint, low cardiorespiratory fitness is associated with impaired vascular structure and function (36,57).”
BackgroundReference Standards for Cardiorespiratory Fitness in Brazil
Milani, M., Milani, J. G. P. O., Cipriano, G. F. B., de Castro, I., & Cipriano, G. (2022) · Journal of Cardiopulmonary Rehabilitation and Prevention · doi:10.1097/hcr.0000000000000690 · Cited by 24
Carlini, N. A., Harber, M. P., & Fleenor, B. S. (2024) · The Journal of Physiology · doi:10.1113/jp285636 · Cited by 20
Self-citationFleenor, B. S., Carlini, N. A., Ouyang, A., Du, B., & Harber, M. P. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00745.2022 · Cited by 17
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Metadata
- Authors
- Fleenor, B. S., Carlini, N. A., Kaminsky, L. A., Whaley, M. H., Peterman, J. E., & Harber, M. P.
- Affiliations
- Ball State University (US)
- Corresponding author
- Fleenor, Bradley S.
- ORCID
- Venue
- Journal of Cardiopulmonary Rehabilitation and Prevention
- Published
- 2020-10-05
- Volume
- 41
- Issue
- 2
- Pages
- 122-125
- ISSN
- 1932-7501 (ISSN-L)
- OpenAlex
- W3092478887
- Cited by
- 20
- References
- 29
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 5 · 2023: 3 · 2022: 7 · 2021: 2
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cardiopulmonary Rehabilitation and Prevention (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Keywords
- cardiorespiratory fitness, peak oxygen uptake, pulse wave velocity, brachial systolic blood pressure, cardiovascular risk, older adults, sex differences, LDL cholesterol, body fat percentage
- MeSH terms
- Cardiorespiratory Fitness, Adult, Aging, Exercise Test, Female, Humans, Male, Physical Fitness, Risk Factors, Exercise, Pulse Wave Analysis
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- Fleenor, B. S., Carlini, N. A., Kaminsky, L. A., Whaley, M. H., Peterman, J. E., & Harber, M. P. (2021). Healthy Vascular Aging Is Associated With Higher Cardiorespiratory Fitness. Journal of Cardiopulmonary Rehabilitation and Prevention. https://doi.org/10.1097/hcr.0000000000000530
