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Cited by 118Bariatric Surgery and OutcomesCardiovascular Function and Risk FactorsCardiovascular Health and Disease Prevention

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Weight loss after bariatric surgery improves aortic elastic properties and left ventricular function in individuals with morbid obesity: a 3-year follow-up study

Ikonomidis, Ignatios, Mazarakis, Andreas, Papadopoulos, Costas, Patsouras, Nikolaos, Kalfarentzos, Fotis, Lekakis, John, Kremastinos, Dimitrios T, Alexopoulos, Dimitrios·2007·Journal of Hypertension
DOI 10.1097/hjh.0b013e3280115bfb
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Abstract

OBJECTIVE: To investigate whether weight loss after bariatric surgery (gastric bypass) is associated with changes in aortic function (an important determinant of left ventricular function) and in left ventricular function, in morbidly obese individuals 3 and 36 months after surgery. METHODS: We used echocardiography to evaluate 60 obese individuals [body mass index (BMI) > 40 kg/m2] who underwent surgery and 20 obese individuals who neither underwent surgery nor lost weight, at baseline and at 3 and 36 months of follow-up, and 40 lean individuals (BMI < 25 kg/m2) of similar age, sex and risk factors, at baseline. We measured aortic strain, distensibility, stiffness index, pressure-strain modulus and Doppler indices of left ventricular diastolic dysfunction (ratio of peak early to peak atrial flow velocities, isovolumic relaxation time and deceleration time). RESULTS: Baseline aortic function and Doppler diastolic indices were impaired in obese individuals compared with those who were lean (P < 0.05). During 3 and 36 months of follow-up, BMI and left ventricular diastolic diameter, volume, mass and wall thickness were reduced, and indices of aortic function and left ventricular diastolic function were normalized, in obese individuals after surgery [aortic distensibility (cm2 x dyn(-1) x 10(-6)): 1.9 before surgery, 3.4 at 3 months after surgery and 4.3 at 3 years after surgery, compared with 3.36 in lean controls; P < 0.01], but not in those who did not lose weight. The reduction in BMI after surgery was related to the concomitant improvement in indices of aortic function (P < 0.01) and isovolumic relaxation time (P < 0.05) after adjustment for age, sex and concomitant reduction in blood pressure, lipids and glucose concentrations. CONCLUSION: Weight reduction after bariatric surgery normalizes aortic function, reduces left ventricular hypertrophy and, thus, improves left ventricular diastolic function in morbidly obese individuals over a 3-year period of follow-up.

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Crossref · 10.1097/hjh.0b013e3280115bfb

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Metadata

Authors
Ikonomidis, I., Mazarakis, A., Papadopoulos, C., Patsouras, N., Kalfarentzos, F., Lekakis, J., Kremastinos, D. T., & Alexopoulos, D.
Affiliations
  • National and Kapodistrian University of Athens (GR)
  • General University Hospital of Patras (GR)
Corresponding author
Ikonomidis, Ignatios
ORCID
Venue
Journal of Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2007-02
Volume
25
Issue
2
Pages
439-447
ISSN
0263-6352 (ISSN-L)
DOI
10.1097/hjh.0b013e3280115bfb
OpenAlex
W1966266926
Cited by
118
References
35
Citations by year
2026: 2 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 3 · 2019: 6 · 2018: 4 · 2017: 8 · 2016: 5 · 2015: 9 · 2014: 10 · 2013: 14 · 2012: 11
FWCI
7.97
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords
bariatric surgery, gastric bypass, morbid obesity, weight loss, aortic function, aortic distensibility, aortic stiffness, left ventricular diastolic function, left ventricular hypertrophy, isovolumic relaxation time, long-term follow-up
MeSH terms
Adult, Aorta, Aortic Diseases, Cardiovascular Diseases, Echocardiography, Female, Follow-Up Studies, Humans, Male, Middle Aged, Obesity, Morbid, Time, Weight Loss, Ventricular Function, Left, Hypertrophy, Left Ventricular, Bariatric Surgery

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