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Cited by 16Traumatic Brain Injury and Neurovascular DisturbancesTraumatic Brain Injury ResearchAcute Ischemic Stroke Management

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Increased Risk of Stroke Among Young Adults With Serious Traumatic Brain Injury

McFarlane, Timothy D., Love, Josh, Hanley, Shane, Dixon, Brian E., Hammond, Flora M.·2020·Journal of Head Trauma Rehabilitation
DOI 10.1097/htr.0000000000000539
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Abstract

Objective: To quantify the risk of acute ischemic stroke (AIS) following traumatic brain injury (TBI) according to severity. Setting: Indiana Network for Patient Care, including medical records from more than 100 Indiana hospitals and affiliated practices. Participants: Individuals 18 years and older with TBI from 2005 to 2014. Design: Retrospective cohort. Main Measures: AIS incidence in the first 30, 31 to 180, and 181 days after TBI. Time to AIS using a stratified Cox proportional hazards model. Results: Among 58 294 patients with TBI, AIS risk was greatest in the first 30 days (incidence rate = 23.3 per 1000 person-months), declining to 3.1 and 1.3 per 1000 person-months after 31 to 180 and 181 days or more, respectively. Cervical artery dissection increased the risk of AIS in the first 30 days (incidence rate = 170.9 per 1000 person-months). In the first 30 days, serious TBI increased risk for all age groups, with the largest effect observed among those aged 18 to 24 years. Over time, serious TBI modified the effect of age on AIS only for those aged 18 to 24 years. Conclusions: These findings add to a growing body of work demonstrating that the acute and postacute stages of TBI play an accelerative role in AIS risk, particularly among younger patients, cervical artery dissection, and serious TBI.

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Crossref · 10.1097/htr.0000000000000539

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Citations

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Research works printed but not linked: 25

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Metadata

Authors
McFarlane, T. D., Love, J., Hanley, S., Dixon, B. E., & Hammond, F. M.
Affiliations
Regenstrief Institute (US)
ORCID
Venue
Journal of Head Trauma Rehabilitation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2020-05
Volume
35
Issue
3
Pages
E310-E319
ISSN
0885-9701 (ISSN-L)
DOI
10.1097/htr.0000000000000539
OpenAlex
W2995419839
Cited by
16
References
1
Citations by year
2026: 1 · 2025: 4 · 2024: 1 · 2022: 5 · 2021: 1 · 2020: 4
FWCI
1.69
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Head Trauma Rehabilitation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Keywords
traumatic brain injury, acute ischemic stroke, stroke risk, cervical artery dissection, young adults, age effects, TBI severity, stroke incidence
MeSH terms
Brain Injuries, Traumatic, Adolescent, Brain Ischemia, Humans, Indiana, Retrospective Studies, Risk Factors, Incidence, Stroke, Young Adult

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