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SUBRETINAL DRUSENOID DEPOSITS IN NON-NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: Morphology, Prevalence, Topography, and Biogenesis Model
Open accessAbstract
In Brief Purpose: To characterize the morphology, prevalence, and topography of subretinal drusenoid deposits, a candidate histological correlate of reticular pseudodrusen, with reference to basal linear deposit (BlinD), a specific lesion of age-related macular degeneration, and to propose a biogenesis model for both lesion. Methods: Donor eyes with median death-to-preservation of 2:40 hours were postfixed in osmium tannic acid paraphenylenediamine and prepared for macula-wide high-resolution digital sections. Annotated thicknesses of 21 chorioretinal layers were determined at standard locations in sections through the fovea and the superior perifovea. Results: In 22 eyes of 20 white donors (83.1 ± 7.7 years), SDD appeared as isolated or confluent drusenoid dollops punctuated by tufts of retinal pigment epithelium apical processes and associated with photoreceptor perturbation. Subretinal drusenoid deposits and BlinD were detected in 85 and 90% of non-neovascular age-related macular degeneration donors, respectively. Subretinal drusenoid deposit was thick (median, 9.4 μm) and more abundant in the perifovea than in the fovea (P < 0.0001). BlinD was thin (median, 2.1 μm) and more abundant in the fovea than in the perifovea (P < 0.0001). Conclusion: Subretinal drusenoid deposits and BlinD prevalence in age-related macular degeneration eyes are high. Subretinal drusenoid deposits organized morphology, topography, and impact on surrounding photoreceptors imply specific processes of biogenesis. Contrasting topographies of subretinal drusenoid deposits and BlinD suggest relationships with differentiable aspects of rod and cone physiology, respectively. A 2-lesion 2-compartment biogenesis model incorporating outer retinal lipid homeostasis is presented. The largest series of eyes devoted to histological characterization of subretinal drusenoid deposit, a candidate correlate of reticular pseudodrusen, shows that it is a stereotyped extracellular lesion that is as prevalent in age-related macular degeneration eyes as basal linear deposit. A 2-lesion 2-compartment biogenesis model invoking photoreceptor lipid homeostasis is proposed.
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“This difference is to be expected, given that basal linear deposits form mostly in the fovea (Curcio et al., 2013), a small central region of the macula that contains only cone photoreceptors (Osterberg, 1935), which is not present in a mouse retina.”
From Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis (2015) · cites this paper as Curcio et al., 2013
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Human photoreceptor topography
Curcio, C. A., Sloan, K. R., Kalina, R. E., & Hendrickson, A. E. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902920402 · Cited by 2,792
Self-citationTopography of ganglion cells in human retina
Curcio, C. A., & Allen, K. A. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.903000103 · Cited by 1,849
Self-citationThe Wisconsin Age-related Maculopathy Grading System
Klein, R., Davis, M. D., Magli, Y. L., Segał, P., Klein, R., & Hubbard, L. D. (1991) · Ophthalmology · doi:10.1016/s0161-6420(91)32186-9 · Cited by 1,188
ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models
Cramer, P. E., Cirrito, J. R., Wesson, D. W., Lee, C. Y. D., Karlo, J. C., Zinn, A. E., Casali, B. T., Restivo, J. L., Goebel, W. D., James, M. J., et al. (2012) · Science · doi:10.1126/science.1217697 · Cited by 1,050
Vaisar, T., Pennathur, S., Green, P. S., Gharib, S. A., Hoofnagle, A. N., Cheung, M. C., Byun, J., Vuletic, S., Kassim, S., Singh, P., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci26206 · Cited by 942 · cited 1×
“Fewer than half subserve lipid metabolism.(68) Brain cerebrospinal fluid, embryologically equivalent to the subretinal space, also harbors HDL-like lipoproteins containing apoE.”
BackgroundAgeing and degeneration in the macular region: A clinico-pathological study
Sarks, S. H. (1976) · British Journal of Ophthalmology · doi:10.1136/bjo.60.5.324 · Cited by 891
Evolution of geographic atrophy of the retinal pigment epithelium
Sarks, J. P., Sarks, S. H., & Killingsworth, M. C. (1988) · Eye · doi:10.1038/eye.1988.106 · Cited by 802
Age-related Macular Degeneration Histopathologic Studies
Green, W. R., & Enger, C. (1993) · Ophthalmology · doi:10.1016/s0161-6420(93)31466-1 · Cited by 757
Chen, W., Stambolian, D., Edwards, A. O., Branham, K. E., Othman, M., Jakobsdottir, J., Tosakulwong, N., Pericak-Vance, M. A., Campochiaro, P. A., Klein, M. L., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912702107 · Cited by 506
Reticular Pseudodrusen Are Subretinal Drusenoid Deposits
Zweifel, S. A., Spaide, R. F., Curcio, C. A., Malek, G., & Imamura, Y. (2009) · Ophthalmology · doi:10.1016/j.ophtha.2009.07.014 · Cited by 494
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Barresi, C., Chhablani, J. K., Dolz‐Marco, R., Gallego‐Pinazo, R., Berni, A., Bandello, F. M., & Borrelli, E. (2023) · European Journal of Ophthalmology · doi:10.1177/11206721231186166 · Cited by 23
Tiosano, L., Corradetti, G., & Sadda, S. R. (2021) · Eye · doi:10.1038/s41433-020-01298-9 · Cited by 22
Lee, J., Kim, J. Y., Jung, B. J., & Lee, W. K. (2018) · Retina · doi:10.1097/iae.0000000000002187 · Cited by 22
ABUNDANCE AND MULTIMODAL VISIBILITY OF SOFT DRUSEN IN EARLY AGE-RELATED MACULAR DEGENERATION
Chen, L., Messinger, J. D., Sloan, K. R., Wong, J., Roorda, A., Duncan, J. L., & Curcio, C. A. (2020) · Retina · doi:10.1097/iae.0000000000002893 · Cited by 22
Self-citationLeisy, H. B., Ahmad, M. T., Marmor, M. F., & Smith, R. T. (2016) · Ophthalmology Retina · doi:10.1016/j.oret.2016.08.011 · Cited by 22
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Hogg, R. E. (2014) · Optometry and Vision Science · doi:10.1097/opx.0000000000000287 · Cited by 22
What Does Genetics Tell Us About Age-Related Macular Degeneration?
Graßmann, F., Ach, T., Brandl, C., Heid, I. M., & Weber, B. H. F. (2015) · Annual Review of Vision Science · doi:10.1146/annurev-vision-082114-035609 · Cited by 21
Naysan, J., Jung, J. J., Dansingani, K. K., Balaratnasingam, C., & Freund, K. B. (2015) · Retina · doi:10.1097/iae.0000000000000758 · Cited by 21
Ledesma‐Gil, G., Fernández-Avellaneda, P., & Spaide, R. F. (2020) · Retina · doi:10.1097/iae.0000000000002866 · Cited by 21
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Murro, V., Mucciolo, D. P., Passerini, I., Palchetti, S., Sodi, A., Virgili, G., & Rizzo, S. (2017) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-017-3751-5 · Cited by 20
Ly, A., Yapp, M., Nivison‐Smith, L., Assaad, N. N., Hennessy, M., & Kalloniatis, M. (2017) · Clinical and Experimental Optometry · doi:10.1111/cxo.12624 · Cited by 20
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Self-citationDey, N., Hong, S., Ach, T., Koutalos, Y., Curcio, C. A., Smith, R. T., & Gerig, G. (2019) · Medical Image Analysis · doi:10.1016/j.media.2019.05.009 · Cited by 15
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Heiferman, M. J., Fernandes, J. K., Munk, M. R., Mirza, R. G., Jampol, L. M., & Fawzi, A. A. (2015) · Retina · doi:10.1097/iae.0000000000000666 · Cited by 11
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Querques, G. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-17133 · Cited by 9
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Abdolrahimzadeh, S., Zweifel, S. A., Pippo, M. D., Bajka, A., Scuderi, G., & Lotery, A. J. (2023) · Eye · doi:10.1038/s41433-023-02654-1 · Cited by 8
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Kim, J. H., Chang, Y. S., Kim, J. W., Lee, D. W., Kim, C. G., & Lee, D. W. (2016) · Japanese Journal of Ophthalmology · doi:10.1007/s10384-016-0466-9 · Cited by 8
Krytkowska, E., Olejnik-Wojciechowska, J., Grabowicz, A., Safranow, K., & Machalińska, A. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12247728 · Cited by 7
Bellis, R., Fei, Y., Le, B., Ledesma‐Gil, G., Otero-Marquez, O., Tong, Y., Tai, K. W., Rosen, R. B., Lema, G. M. C., & Smith, R. T. (2024) · BMJ Open Ophthalmology · doi:10.1136/bmjophth-2023-001622 · Cited by 7
Nam, K. T., Chung, H. W., Jang, S., Hwang, S. Y., Kim, S., Oh, J., & Yun, C. (2021) · Retina · doi:10.1097/iae.0000000000003100 · Cited by 7
Grewal, M. K., Chandra, S., Bird, A. C., Jeffery, G., & Sivaprasad, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-89677-4 · Cited by 7
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Clemens, C. R., Eter, N., & Alten, F. (2024) · Ophthalmologica · doi:10.1159/000536278 · Cited by 7
Iliescu, D. A., Ghiță, A. C., Ilie, L. A., Voiculescu, S. E., Geamănu, A., & Ghiță, M. (2024) · Diagnostics · doi:10.3390/diagnostics14070764 · Cited by 7
Carr, B. J., Skitsko, D., Kriese, L. M., Song, J. L., Li, Z., Ju, M. J., & Moritz, O. L. (2024) · Journal of Cell Science · doi:10.1242/jcs.262298 · Cited by 7
Ţurcaş, C., & Nicoară, S. (2025) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2025.01.009 · Cited by 7
Pettenkofer, M. S., Scherm, P., Feucht, N., Wehrmann, K., Lohmann, C. P., & Maier, M. M. (2019) · Ophthalmic surgery, lasers & imaging retina · doi:10.3928/23258160-20190503-07 · Cited by 7
Genetic and environmental risk factors for reticular pseudodrusen in the EUGENDA study.
Altay, L., Liakopoulos, S., Berghold, A., Rosenberger, K. D., Ernst, A., de Breuk, A., den Hollander, A. I., Fauser, S., & Schick, T. (2021) · PubMed Central · Cited by 7
Light, J. G., Fard, M. A., Yaseri, M., Aiyetan, P., Handa, J. T., & Ebrahimi, K. B. (2017) · Retina · doi:10.1097/iae.0000000000001484 · Cited by 7
Olsen, T. W., Bottini, A. R., Mendoza, P. R., & Grossniklausk, H. E. (2015) · Europe PMC (PubMed Central) · Cited by 7
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Wilde, C., Awad, M., Dua, H. S., Gandhewar, R., Chen, H.-C., & Amoaku, W. M. K. (2018) · Ophthalmology Retina · doi:10.1016/j.oret.2018.06.009 · Cited by 7
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Vilela, M. A. P., & Parodi, M. B. (2022) · European Journal of Ophthalmology · doi:10.1177/11206721221102269 · Cited by 6
Transthyretin proteoforms of intraocular origin in human subretinal fluid
Chen, J., Cao, D., Fortmann, S. D., Curcio, C. A., Feist, R. M., & Crosson, J. N. (2022) · Experimental Eye Research · doi:10.1016/j.exer.2022.109163 · Cited by 6
Self-citationHiggins, B. E., Montesano, G., Crabb, D. P., Naskas, T. T., Graham, K. W., Chakravarthy, U., Kee, F., Wright, D. M., & Hogg, R. E. (2022) · Ophthalmology Science · doi:10.1016/j.xops.2022.100204 · Cited by 6
Kang, D., Lee, Y. J., Nam, K. T., Choi, M., & Yun, C. (2023) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-023-06127-9 · Cited by 6
Biomaterial templates for the culture and transplantation of retinal pigment epithelial cells
Shadforth, A. M. A., Chirilă, T. V., Harkin, D. G., Kwan, A., & Chen, F. K. (2016) · Elsevier eBooks · doi:10.1016/b978-0-08-100147-9.00011-0 · Cited by 6
Curcio, C. A., & Owsley, C. J. (2026) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.67.3.34 · Cited by 5
Self-citationToma, C., Gatti, V., Servillo, A., Galotta, A., Leonardi, M., Ferrante, D., Torti, E., Leporati, F., & Cillà, S. D. (2024) · European Journal of Ophthalmology · doi:10.1177/11206721241293494 · Cited by 5
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Metadata
- Authors
- Curcio, C. A., Messinger, J. D., Sloan, K. R., McGwin, G., Medeiros, N. E., & Spaide, R. F.
- Affiliations
- University of Alabama at Birmingham (US)
- Vitreous Retina Macula Consultants of New York (US)
- Corresponding author
- Curcio, Christine A.
- Messinger, Jeffrey D.
- Venue
- Retina
- Published
- 2013-02
- Volume
- 33
- Issue
- 2
- Pages
- 265-276
- ISSN
- 0275-004X (ISSN-L)
- PMC
- PMC3870202
- OpenAlex
- W2045011938
- Cited by
- 384
- References
- 86
- Citations by year
- 2026: 25 · 2025: 15 · 2024: 27 · 2023: 18 · 2022: 35 · 2021: 28 · 2020: 28 · 2019: 27 · 2018: 37 · 2017: 32 · 2016: 32 · 2015: 35 · 2014: 36 · 2013: 9
- FWCI
- 23.94
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Retina (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Eye Institute (R01EY006109, EY06109)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Keywords
- subretinal drusenoid deposits, reticular pseudodrusen, non-neovascular age-related macular degeneration, retinal pigment epithelium, perifovea, fovea
- MeSH terms
- Aged, 80 and over, Female, Fovea Centralis, Humans, Male, Models, Biological, Tissue Donors, Retinal Drusen, Eye Diseases, Hereditary, Prevalence, Bruch Membrane, Topography, Medical, White People, Retinal Pigment Epithelium, Geographic Atrophy
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