Complications of intravitreal injections: 2022

Patel, Dillan; Patel, Samir N.; Chaudhary, Varun; Garg, Sunir J.

doi:10.1097/icu.0000000000000850

Cited by 92Ocular Infections and TreatmentsRetinal Diseases and TreatmentsOcular Diseases and Behçet’s Syndrome

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Complications of intravitreal injections: 2022

Patel, Dillan, Patel, Samir N., Chaudhary, Varun, Garg, Sunir J.·2022·Current Opinion in Ophthalmology

DOI 10.1097/icu.0000000000000850

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Abstract

PURPOSE OF REVIEW: This review highlights the complications of both intravitreal injection procedure as well as different intravitreal medications including antivascular endothelial growth factors, antibiotics, antivirals, antifungals, methotrexate, and steroids. Techniques for reducing rates of endophthalmitis will also be discussed. RECENT FINDINGS: Intravitreal vancomycin can cause hemorrhagic occlusive retinal vasculitis resulting in severe vision loss. Intravitreal brolucizumab is associated with intraocular inflammation and retinal vasculitis resulting in significant vision loss. Face mask use by both patient and physician is not associated with increased risk of endophthalmitis and may decrease culture positive endophthalmitis. SUMMARY: Intravitreal injections continue to be one of the most commonly performed procedures by ophthalmologists. Although the injections are generally well tolerated, sight-threatening complications can occur including endophthalmitis, retinal detachment, and/or retinal vasculitis. Adverse events associated with specific medications are outlined below. Several safety measures have been shown to reduce rates of endophthalmitis, the most concerning complication of this procedure.

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Current anti-VEGF therapies require frequent intravitreal injections, which are inconvenient and may lead to potential complications such as endophthalmitis, retinal detachment and retinal hemorrhage.
“Current anti-VEGF therapies, while effective, require frequent intravitreal injections, which are inconvenient and may lead to potential complications such as endophthalmitis, retinal detachment and retinal hemorrhage [165].”
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“Current anti-VEGF therapies, while effective, require frequent intravitreal injections, which are inconvenient and may lead to potential complications such as endophthalmitis, retinal detachment and retinal hemorrhage [165].”

Authors: Patel, D., Patel, S. N., Chaudhary, V., & Garg, S. J.
Affiliations: Temple University Hospital (US)
Thomas Jefferson University (US)
McMaster University (CA)
Corresponding author: Garg, Sunir J.
Venue: Current Opinion in Ophthalmology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2022-03-09
Volume: 33
Issue: 3
Pages: 137-146
ISSN: 1040-8738 (ISSN-L)
1531-7021
DOI: 10.1097/icu.0000000000000850
OpenAlex: W4220963031
Cited by: 92
References: 100
Citations by year: 2026: 22 · 2025: 22 · 2024: 27 · 2023: 17 · 2022: 3
FWCI: 3.71
Type: journal article
Language: en
Open access: closed
Locations: Current Opinion in Ophthalmology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords: intravitreal injection complications, endophthalmitis, intravitreal vancomycin, brolucizumab, retinal vasculitis, intraocular inflammation, masking, retinal detachment, intravitreal antibiotics, intravitreal methotrexate, intravitreal steroids, VEGF inhibitors, vision loss
MeSH terms: Anti-Bacterial Agents, Humans, Endophthalmitis, Retina, Retrospective Studies, Vancomycin, Eye Infections, Bacterial, Angiogenesis Inhibitors, Retinal Vasculitis, Intravitreal Injections

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Complications of intravitreal injections: 2022

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