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FGF-2 Angiogenesis in Bone Regeneration Within Critical-Sized Bone Defects in Rat Calvaria
Abstract
OBJECTIVE: This study examined the effect of basic fibroblast growth factor (FGF)-2 with an absorbable collagen sponge on angiogenesis and bone regeneration in rat calvarial critical-sized bone defects using microcomputed tomography. METHODS: Forty 7-week-old male Fischer rats were used. The symmetrical critical-sized calvarial bone defects (5 mm diameter) were created. An absorbable collagen sponge with or without FGF-2 (0.1% or 0.3%) was implanted into each bone defect. RESULTS: Blood vessel and bone volumes were significantly higher in the 0.3% FGF-2 group compared with the control and 0.1% FGF-2 groups on day 28. Significantly more osteoblast- and osteoclast-like cells were seen in the 0.3% FGF-2 group. CONCLUSIONS: Thus, FGF-2 increased blood vessel and bone formation in rat calvarial critical-sized bone defects.
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“Among these, major regulators within the bone remodeling cascade are bone morphogenetic proteins (BMPs), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), transforming growth factor-β1 (TGF-β1), and insulin-like growth factor 1 (IGF-1) [39,69,70,71,72,73,74,75,76].”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [73]
In the citing paper
“Following bone injury, the bone’s extracellular matrix releases a physiological amount of growth factors which play a vital role in bone repair.”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [73]
In the citing paper
“Also, FGF, especially FGF-2, plays a role in angiogenesis and bone regeneration.”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [73]
In the citing paper
“Studies administering FGF-2 to rat calvarial defects via a collagen sponge have demonstrated augmented osteoblast differentiation, increased blood vessel formation, and higher bone volume generation based on FGF-2 concentrations [39,73].”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [73]
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EPO Promotes Bone Repair through Enhanced Cartilaginous Callus Formation and Angiogenesis
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Metadata
- Authors
- Kigami, R., Sato, S., Tsuchiya, N., Yoshimakai, T., Arai, Y., & Ito, K.
- Affiliations
- Nihon University (JP)
- Corresponding author
- Kigami, Risa
- Tsuchiya, Noriko
- Yoshimakai, Tomohiro
- Venue
- Implant Dentistry
- Published
- 2013-08
- Volume
- 22
- Issue
- 4
- Pages
- 422-427
- ISSN
- 1056-6163 (ISSN-L)
- OpenAlex
- W2021429147
- Cited by
- 46
- References
- 26
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 6 · 2017: 2 · 2016: 5 · 2015: 5 · 2014: 3 · 2013: 3
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Implant Dentistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (25463056)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
- Health Sciences › Dentistry › Oral Surgery › Dental Implant Techniques and Outcomes
- Keywords
- basic fibroblast growth factor, angiogenesis, bone regeneration, critical-size bone defect, calvaria, absorbable collagen sponge, bone formation, osteoblasts, osteoclasts
- MeSH terms
- Animals, Bone Diseases, Bone Regeneration, Collagen, Contrast Media, Image Processing, Computer-Assisted, Iopamidol, Male, Osteoblasts, Osteoclasts, Osteogenesis, Parietal Bone, Rats, Inbred F344, Time Factors, X-Ray Intensifying Screens, Fibroblast Growth Factor 2, Neovascularization, Physiologic, Absorbable Implants, Tissue Engineering, Rats, Tissue Scaffolds, X-Ray Microtomography, Microvessels
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