Comparison of antimicrobial stewardship and infection prevention and control activities and resources between low-/middle- and high-income countries
Open accessAbstract
BACKGROUND: The growth of antimicrobial resistance worldwide has led to increased focus on antimicrobial stewardship (AMS) and infection prevention and control (IPC) measures, although primarily in high-income countries (HIC). We aimed to compare pediatric AMS and IPC resources/activities between low- and middle-income countries (LMIC) and HIC and to determine the barriers and priorities for AMS and IPC in LMIC as assessed by clinicians in those settings. METHODS: An online questionnaire was distributed to clinicians working in HIC and LMIC healthcare facilities in 2020. RESULTS: Participants were from 135 healthcare settings in 39 LMIC and 27 HIC. Formal AMS and IPC programs were less frequent in LMIC than HIC settings (AMS 42% versus 76% and IPC 58% versus 89%). Only 47% of LMIC facilities conducted audits of antibiotic use for pediatric patients, with less reliable availability of World Health Organization Access list antibiotics (29% of LMIC facilities). Hand hygiene promotion was the most common IPC intervention in both LMIC and HIC settings (82% versus 91%), although LMIC hospitals had more limited access to reliable water supply for handwashing and antiseptic hand rub. The greatest perceived barrier to pediatric AMS and IPC in both LMIC and HIC was lack of education: only 17% of LMIC settings had regular/required education on antimicrobial prescribing and only 25% on IPC. CONCLUSIONS: Marked differences exist in availability of AMS and IPC resources in LMIC as compared with HIC. A collaborative international approach is urgently needed to combat antimicrobial resistance, using targeted strategies that address the imbalance in global AMS and IPC resource availability and activities.
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A recent survey with participants from over 66 countries indicated that LMICs have a lower number of IPC and AMS programmes compared with high-income countries.
“A recent study, reporting on survey findings conducted with participants from over 66 countries indicated that LMICs have a lower number of infection prevention and control (IPC) and AMS programmes compared with high-income countries.21”
From Rationalizing irrational prescribing—infection-related attitudes and practices across paediatric surgery specialties in a hospital in South India (2024) · cites this paper as [21]
The Results report that formal AMS and IPC programmes were less frequent in LMIC than HIC healthcare settings. The survey covered exactly 66 countries, not over 66, and the comparison concerns the participating healthcare settings rather than all facilities in those countries. (LLM, conf=0.92)
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Sorted by citations
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- Authors
- Villanueva, P., Coffin, S. E., Mekasha, A., McMullan, B., Cotton, M. F., & Bryant, P. A.
- Affiliations
- Royal Children's Hospital (AU)
- Children's Hospital of Philadelphia (US)
- Tikur Anbessa Hospital (ET)
- The University of Melbourne (AU)
- Stellenbosch University (ZA)
- Corresponding author
- Villanueva, Paola
- Mekasha, Amha
- Bryant, Penelope A.
- ORCID
- McMullan, Brendan
- Venue
- Pediatric Infectious Disease Journal
- Published
- 2022-02-08
- Volume
- 41
- Issue
- 3S
- Pages
- S3-S9
- ISSN
- 0891-3668 (ISSN-L)
- PMC
- PMC8815833
- OpenAlex
- W4210887061
- Cited by
- 47
- References
- 23
- Citations by year
- 2026: 12 · 2025: 16 · 2024: 12 · 2023: 5 · 2022: 2
- FWCI
- 5.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The Pediatric Infectious Disease Journal (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
- Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
- Health Sciences › Medicine › Surgery › Surgical site infection prevention
- Keywords
- antimicrobial stewardship, infection control, antimicrobial resistance, low- and middle-income countries, high-income countries, pediatric patients, hand hygiene, clinician education, implementation barriers, global health disparities
- MeSH terms
- Antimicrobial Stewardship, Developing Countries, Health Facilities, Health Resources, Humans, Health Knowledge, Attitudes, Practice, Pediatrics, Surveys and Questionnaires, Infection Control, Developed Countries
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