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Cited by 122Cervical Cancer and HPV ResearchHead and Neck Cancer StudiesOral Health Pathology and Treatment

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Prevalence of human papillomavirus in the oral cavity/oropharynx in a large population of children and adolescents.

Smith, Elaine M., Swarnavel, Sandhya, Ritchie, Justine M., Wang, Donghong, Haugen, Thomas H., Turek, Lubomir P.·2007·Pediatric Infectious Disease Journal
DOI 10.1097/inf.0b013e318124a4ae
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Abstract

OBJECTIVE: Human papillomavirus (HPV) in the oral cavity or oropharynx is associated with an increased risk of laryngeal papillomatosis, head and neck cancer, and cervical and other genital cancers. We evaluated the prevalence of HPV DNA in the oral cavity/oropharynx in a cross section of children aged 2 weeks to 20 years. METHODS: A risk factor questionnaire and oral exfoliated cells were collected from children (N = 1235). HPV DNA was detected using PCR, dot blot hybridization, and DNA sequencing. RESULTS: The HPV prevalence was 1.9% in the oral cavity/oropharynx of children. A bimodal age distribution was observed with the highest HPV prevalence in the youngest and oldest groups: 2.5% aged <1 year, 0.8% aged 1 to 4 years, 1.2% aged 5 to 11 years, 1.5% in aged 12 to 15 years, and 3.3% in aged 16 to 20 years. The prevalence of the HPV quadrivalent vaccine types (HPV-6, 11, 16, 18) reached 0.9% in the 16- to 20-year age group. In this age group, female gender [odds ratio (OR): 6.9, P = 0.04], genital warts (OR: 19.3, P < 0.01), and current smoker (OR: 6.5, P = 0.01) were associated with a higher risk of being detected with an oral HPV infection. No risk factors in parents were identified with transmission of HPV to infants. CONCLUSIONS: The age-specific prevalence rates of HPV in this large cross section of children and adolescents demonstrate that HPV infection is acquired gradually in childhood. These data support a target age for HPV vaccination before puberty to prevent serious HPV-related genital and oral diseases.

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  1. Harper, 2006, Sustained efficacy up to 4.5 years of a bivalent L1 virus-like particle vaccine against human papillomavirus types 16 and18 in young women: a randomized controlled trial., Lancet Oncol, 364, 1757, 10.1016/S0140-6736(04)17398-4 · DOI

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Metadata

Authors
Smith, E. M., Swarnavel, S., Ritchie, J. M., Wang, D., Haugen, T. H., & Turek, L. P.
Affiliations
University of Iowa (US)
Corresponding author
  • Smith, Elaine M.
  • Swarnavel, Sandhya
ORCID
Venue
Pediatric Infectious Disease Journal
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2007-09
Volume
26
Issue
9
Pages
836-840
ISSN
0891-3668 (ISSN-L)
DOI
10.1097/inf.0b013e318124a4ae
OpenAlex
W1991658990
Cited by
122
References
19
Citations by year
2025: 3 · 2024: 1 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 6 · 2015: 8 · 2014: 13 · 2013: 14 · 2012: 18
FWCI
7.05
Type
journal article
Language
en
Open access
closed
Locations
  • The Pediatric Infectious Disease Journal (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5p50de010758-05)
  • National Institute of Dental and Craniofacial Research (DE10758)
Topics
  • Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
  • Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
  • Health Sciences › Dentistry › General Dentistry › Oral Health Pathology and Treatment
Keywords
human papillomavirus, oral HPV infection, oropharynx, children and adolescents, HPV prevalence, age-specific prevalence, genital warts, smoking, recurrent respiratory papillomatosis, oral exfoliated cells, risk factors
MeSH terms
Adolescent, Adult, Child, Child, Preschool, Female, Hospitals, University, Humans, Infant, Infant, Newborn, Iowa, Male, Mouth, Pharynx, Surveys and Questionnaires, Risk Factors, Prevalence, Sequence Analysis, DNA, Sex Distribution, Papillomavirus Infections, Alphapapillomavirus

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