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Autoantibodies in patients with fibromyalgia syndrome
Abstract
The objective of this study was to assess the frequency of IgG autoantibodies in patients with fibromyalgia syndrome (FMS), to characterize their binding to dorsal root ganglion (DRG) neurons and glial cells, and to assess whether specific DRG binding patterns correlate with clinical symptoms. Sera of a cohort of 184 patients with FMS and 55 control sera were used to test binding of patient IgG on rat DRG sections. ELISA, Western blot, and preadsorption tests were used to search for potential target antigens. We found binding to DRGs in 68 of 184 FMS sera and in none of the control sera. We could identify 9 binding clusters including binding to neurons and to cells labelled with the satellite glial cell marker fatty acid binding protein 7 (FABP7). Current pain intensity correlated positively with IgG binding to FABP7 immunoreactive structures, and burning pain was associated with binding to transient receptor potential vanilloid 1 immunoreactive neurons. Specific antibody detection revealed 13 of 68 sera positive for anti-citrullinated peptide antibodies, 9 of 68 positive for SOX1 antibodies, 7 of 68 positive for antibodies against the serotonin receptor 5HT1AR, and 3 of 68 positive for fibroblast growth factor 3 antibodies. Our findings support the notion of an immune activation in a subgroup of patients with FMS.
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“suggesting that autoimmune antibodies may participate in FMS mediated by SCGs (110).”
From Nociplastic pain: the prominent role of non-neuronal cells in central and peripheral sensitization (2026) · cites this paper as [110]
In the citing paper
“Studies have shown that purified IgG extracted from FMS patients with FMS specifically binds to rat dorsal root ganglia (DRG), with nine distinct binding clusters identified”
From Nociplastic pain: the prominent role of non-neuronal cells in central and peripheral sensitization (2026) · cites this paper as [110]
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Passive transfer of fibromyalgia symptoms from patients to mice
Goebel, A., Krock, E., Gentry, C., Israel, M. R., Jurczak, A., Urbina, C. M., Sandor, K., Vastani, N., Maurer, M., Cuhadar, U., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci144201 · Cited by 278
Reduction of skin innervation is associated with a severe fibromyalgia phenotype
Evdokimov, D., Frank, J., Klitsch, A., Unterecker, S., Warrings, B., Serra, J., Papagianni, A., Saffer, N., Meyer zu Altenschildesche, C., Kampik, D., et al. (2019) · Annals of Neurology · doi:10.1002/ana.25565 · Cited by 152
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Research works printed but not linked: 26
- Alghamdi, 2019, An overview of the intrinsic role of citrullination in autoimmune disorders, J Immunol Res, 2019, 7592851, 10.1155/2019/7592851 · DOI
- Antoine, 2015, Antifibroblast growth factor receptor 3 antibodies identify a subgroup of patients with sensory neuropathy, J Neurol Neurosurg Psychiatry, 86, 1347, 10.1136/jnnp-2014-309730 · DOI
- Avraham, 2020, Satellite glial cells promote regenerative growth in sensory neurons, Nat Commun, 11, 4891, 10.1038/s41467-020-18642-y · DOI
- Barcelon, 2023, Sexual dimorphism in the mechanism of pain central sensitization, Cells, 12, 2028, 10.3390/cells12162028 · DOI
- Berger, 2016, Prevalence of anti-SOX1 reactivity in various neurological disorders, J Neurol Sci, 369, 342, 10.1016/j.jns.2016.09.002 · DOI
- Burbelo, 2021, Autoantibodies targeting intracellular and extracellular proteins in autoimmunity, Front Immunol, 12, 548469, 10.3389/fimmu.2021.548469 · DOI
- Cruz-Aguilera, 2022, Serum anti-neural immunoreactivity in patients with fibromyalgia. Preliminary study, Gac Med Mex, 158, 104
- Evdokimov, 2020, Characterization of dermal skin innervation in fibromyalgia syndrome, PLoS One, 15, e0227674, 10.1371/journal.pone.0227674 · DOI
- Farhad, 2019, Current diagnosis and treatment of painful small fiber neuropathy, Curr Neurol Neurosci Rep, 19, 103, 10.1007/s11910-019-1020-1 · DOI
- García, 2023, Two putative glutamate decarboxylases of Streptococcus pneumoniae as possible antigens for the production of anti-GAD65 antibodies leading to type 1 diabetes mellitus, Int Microbiol, 26, 675, 10.1007/s10123-023-00364-y · DOI · Paper page
- Ghavidel-Parsa, 2023, The crosstalk of the pathophysiologic models in fibromyalgia, Clin Rheumatol, 42, 3177, 10.1007/s10067-023-06778-3 · DOI
- Gyorfi, 2022, Fibromyalgia pathophysiology, Biomedicines, 10, 3070, 10.3390/biomedicines10123070 · DOI
- Krock, 2023, Fibromyalgia patients with elevated levels of anti-satellite glia cell immunoglobulin G antibodies present with more severe symptoms, PAIN, 164, 1828, 10.1097/j.pain.0000000000002881 · DOI · Paper page
- Meester, 2019, Immune System sex differences may bridge the gap between sex and gender in fibromyalgia, Front Neurosci, 13, 1414, 10.3389/fnins.2019.01414 · DOI
- Miyahara, 2021, Involvement of parvalbumin-positive neurons in the development of hyperalgesia in a mouse model of fibromyalgia, Front Pain Res (Lausanne), 2, 627860, 10.3389/fpain.2021.627860 · DOI
- Pisetsky, 2020, New insights into the role of antinuclear antibodies in systemic lupus erythematosus, Nat Rev Rheumatol, 16, 565, 10.1038/s41584-020-0480-7 · DOI
- Ruiz-García, 2019, Caveats and pitfalls of SOX1 autoantibody testing with a commercial line blot assay in paraneoplastic neurological investigations, Front Immunol, 10, 769, 10.3389/fimmu.2019.00769 · DOI
- Sarzi-Puttini, 2008, Anti-polymer antibodies are correlated with pain and fatigue severity in patients with fibromyalgia syndrome, Autoimmunity, 41, 74, 10.1080/08916930701620035 · DOI
- Titulaer, 2009, SOX antibodies in small-cell lung cancer and Lambert-Eaton myasthenic syndrome: frequency and relation with survival, J Clin Oncol, 27, 4260, 10.1200/JCO.2008.20.6169 · DOI
- Tong, 2002, The PEVKEK region of the pyridoxal phosphate binding domain of GAD65 expresses a dominant B cell epitope for type 1 diabetes sera, Ann N Y Acad Sci, 958, 182, 10.1111/j.1749-6632.2002.tb02966.x · DOI
- Tour, 2022, The OPRM1 gene and interactions with the 5-HT1a gene regulate conditioned pain modulation in fibromyalgia patients and healthy controls, PLoS One, 17, e0277427, 10.1371/journal.pone.0277427 · DOI
- Trevino, 2021, TS-HDS and FGFR3 antibodies in small fiber neuropathy and Dysautonomia, Muscle Nerve, 64, 70, 10.1002/mus.27245 · DOI
- Trier, 2022, Peptide antibody reactivity to homologous regions in glutamate decarboxylase isoforms and coxsackievirus B4 P2C, Int J Mol Sci, 23, 4424, 10.3390/ijms23084424 · DOI
- Tschernatsch, 2010, Anti-SOX1 antibodies in patients with paraneoplastic and non-paraneoplastic neuropathy, J Neuroimmunol, 226, 177, 10.1016/j.jneuroim.2010.07.005 · DOI
- Wang, 2019, Neuronal FcγRI mediates acute and chronic joint pain, J Clin Invest, 129, 3754, 10.1172/JCI128010 · DOI
- Wang, 2021, Neuropathic injury-induced plasticity of GABAergic System in peripheral sensory ganglia, Front Pharmacol, 12, 702218, 10.3389/fphar.2021.702218 · DOI
Cited by
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Nociplastic pain: the prominent role of non-neuronal cells in central and peripheral sensitization
Lai, W., Tang, X., Chen, S., Zhou, Y., Qi, Z., Cao, M., Yuan, C., Yu, J., & Wen, C. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1677310 · Cited by 4
“Studies have shown that puri fi ed IgG extracted from FMS patients with FMS speci fi cally binds to rat dorsal root ganglia (DRG), with nine distinct binding clusters identi fi ed, suggesting that autoimmune antibodies may participate in FMS mediated by SCGs (110).”
Metadata
- Authors
- Seefried, S., Barcic, A., Grijalva Yepez, M. F., Reinhardt, L., Appeltshauser, L., Doppler, K., Üçeyler, N., & Sommer, C.
- Affiliations
- Universitätsklinikum Würzburg (DE)
- Corresponding author
- Sommer, Claudia
- Venue
- Pain
- Published
- 2025-02-05
- Volume
- 166
- Issue
- 8
- Pages
- 1922-1933
- ISSN
- 0304-3959 (ISSN-L)
- 1872-6623
- OpenAlex
- W4407156721
- Cited by
- 21
- References
- 2
- Citations by year
- 2026: 13 · 2025: 8
- FWCI
- 14.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (KFO5001)
- Evangelisches Studienwerk Villigst
- Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Würzburg (ZZ-32)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- fibromyalgia, autoantibodies, IgG autoantibodies, dorsal root ganglia, satellite glial cells, FABP7, TRPV1, anti-citrullinated protein antibodies, SOX1, FGF3, immune activation, burning pain, pain intensity, target antigens
- MeSH terms
- Fatty Acid-Binding Protein 7, Adult, Aged, Animals, Autoantibodies, Female, Fibromyalgia, Ganglia, Spinal, Humans, Immunoglobulin G, Male, Middle Aged, Neurons, Fatty Acid-Binding Proteins, TRPV Cation Channels, Rats
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