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Relationship Between Non-small Cell Lung Cancer FDG Uptake at PET, Tumor Histology, and Ki-67 Proliferation Index
Open accessAbstract
Introduction We compared primary non-small cell lung cancer (NSCLC) F-fluorodeoxyglucose (FDG) uptake at positron emission tomography (PET) to tumor histologic features and Ki-67 proliferation index. This large, prospectively-recruited patient cohort has previously been analyzed based on differences in FDG uptake across stage groups; the current analysis adds further dimensions to this characterization. Materials and methods One hundred seventy-eight patients with potentially-resectable NSCLC were scanned with FDG PET before therapy. A partial volume correction algorithm was used to correct FDG uptake values for their dependence on tumor size. Primary tumor resection specimens, core biopsies, and biopsies of metastatic lymph nodes were used to assess each tumor's NSCLC histologic subtype, degree of differentiation, and Ki-67 proliferation index. Results Bronchioalveolar carcinomas were found to have lower FDG uptake at PET and lower Ki-67 scores than any other histologic subtype. Non-bronchioalveolar adenocarcinomas had lower FDG uptake and Ki-67 scores than squamous cell carcinomas or large cell undifferentiated carcinomas. Better differentiated NSCLCs had lower FDG uptake and Ki-67 scores than more poorly differentiated NSCLCs. There was a significant positive correlation between FDG uptake and Ki-67 scores. Partial volume correction increased the strength of this correlation, while also diminishing the strong positive correlation between FDG uptake and tumor size. Conclusions There are significant differences in NSCLC FDG uptake across histologic subtypes and differentiation groups. These differences parallel nearly identical differences in Ki-67 scores, implying that differences in NSCLC tumor cell proliferation may give rise to commensurate differences in tumor glucose metabolism.
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“or benign lesions and well-differentiated malignant lesions with low [18F]FDG avidity [122,123,124,125].”
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Metadata
- Authors
- Vesselle, H., Salskov, A., Turcotte, E., Wiens, L., Schmidt, R., Jordan, C. D., Vallières, E., & Wood, D. E.
- Affiliations
- University of Washington (US)
- Corresponding author
- Vesselle, Hubert
- Venue
- Journal of Thoracic Oncology
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 3
- Issue
- 9
- Pages
- 971-978
- ISSN
- 1556-0864 (ISSN-L)
- OpenAlex
- W1979039258
- Semantic Scholar
- 47e32ad0bcc9c0453f63876438f1cdc0803650f5
- Cited by
- 165
- References
- 50
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 9 · 2022: 13 · 2021: 9 · 2020: 9 · 2019: 4 · 2018: 16 · 2017: 7 · 2016: 10 · 2015: 8 · 2014: 13 · 2013: 10 · 2012: 13
- FWCI
- 9.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Thoracic Oncology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Washington
- National Cancer Institute (1R01 CA80907, R01CA115559, R01CA080907, R01CA107264)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiomics and Machine Learning in Medical Imaging
- Keywords
- non-small cell lung cancer, FDG uptake, positron emission tomography, Ki-67 proliferation index, tumor histologic subtype, tumor differentiation, bronchioloalveolar carcinoma, adenocarcinoma, squamous cell carcinoma, tumor glucose metabolism, partial volume correction, tumor size
- MeSH terms
- Adenocarcinoma, Adenocarcinoma, Bronchiolo-Alveolar, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Female, Humans, Lung Neoplasms, Male, Neoplasm Staging, Prognosis, Prospective Studies, Radiography, Thoracic, Tomography, X-Ray Computed, Biomarkers, Tumor, Cohort Studies, Carcinoma, Large Cell, Radiopharmaceuticals, Ki-67 Antigen, Fluorodeoxyglucose F18, Positron-Emission Tomography
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