CoChat
Sign Up
Cited by 221Liver Disease Diagnosis and TreatmentDiabetes, Cardiovascular Risks, and LipoproteinsAlcohol Consumption and Health Effects

The DOI matches its Crossref record; 45 of the 46 references it cites were found in a registry or an index.

Components of metabolic syndrome increase the risk of mortality in nonalcoholic fatty liver disease (NAFLD)

Open access
Golabi, Pegah, Otgonsuren, Munkhzul, de Avila, Leyla, Sayiner, Mehmet, Rafiq, Nila, Younossi, Zobair M.·2018·Medicine
DOI 10.1097/md.0000000000010214PMC PMC5895395
Open this paper in CoChat — free account

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the United States. Metabolic syndrome (MS) components are highly prevalent in NAFLD. Our aim is to assess the relationship of NAFLD and MS with long-term outcome of mortality.The Third National Health and Nutrition Examination Survey (NHANES) was utilized. NAFLD was diagnosed by ultrasound in the presence of hepatic steatosis and no other causes of chronic liver disease. History of MS and its components were obtained from self-reported NHANES questionnaires. Mortality was obtained from Mortality-Linkage File, through December 31, 2011. Chi-square test was used for categorical variables and Cox proportional models estimated hazard ratios with 95% confidence interval.NAFLD cohort (n = 3613) had a median age of 43 years, 73% white, and 50% male. NAFLD group with at least one MS condition was significantly older, had higher body mass index, more likely to have insulin resistance, and heart disease compared to NAFLD group without MS. Over 19-years of follow-up, 1039 people died. Compared to NAFLD patients without MS, presence of one MS component increased the risk of mortality at 8-year (2.6% vs 4.7%) and 16-year (6% vs 11.9%) (P < .001). After adjusting for socio-demographic factors, NAFLD with all MS components was associated with overall, cardiac and liver-mortality. Increased number of MS components was associated with lower survival (P < .0001).Patients with NAFLD and MS have higher mortality risk compared to NAFLD patients without MS. These NAFLD patients should be prioritized for the development of treatment regimens.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1097/md.0000000000010214

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Figures

Figure 1 Study flow, National Health and Nutrition Examination Survey (NHANES) III.
Figure 1 Study flow, National Health and Nutrition Examination Survey (NHANES) III.CC BY-SA · PubMed Central
Figure 2 Kaplan–Meier survival curves for 23-years follow-up (average = 19 years) of 3613 NAFLD participants, by MS conditions, NHANES III, 2011 public-use linked mortality files. MS = metabolic syndrome, NAFLD = nonalcoholic fatty liver disease, NHANES = National Health and Nutrition Examination Survey.
Figure 2 Kaplan–Meier survival curves for 23-years follow-up (average = 19 years) of 3613 NAFLD participants, by MS conditions, NHANES III, 2011 public-use linked mortality files. MS = metabolic syndrome, NAFLD = nonalcoholic fatty liver disease, NHANES = National Health and Nutrition Examination Survey.CC BY-SA · PubMed Central

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 46 references

Cited by

Sorted by citations

Items 101–200 of 221

Related

See all

Metadata

Authors
Golabi, P., Otgonsuren, M., de Avila, L., Sayiner, M., Rafiq, N., & Younossi, Z. M.
Affiliations
Inova Health System (US)
Corresponding author
Younossi, Zobair M.
ORCID
Venue
Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2018-03
Volume
97
Issue
13
Pages
e0214
ISSN
0025-7974 (ISSN-L)
DOI
10.1097/md.0000000000010214
PMC
PMC5895395
OpenAlex
W2794816422
Cited by
221
References
46
Citations by year
2026: 16 · 2025: 20 · 2024: 32 · 2023: 25 · 2022: 33 · 2021: 36 · 2020: 24 · 2019: 24 · 2018: 9
FWCI
18.15
Type
journal article
Language
en
Open access
Licence
cc-by-sa
Locations
  • Medicine (publishedVersion, cc-by-sa)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-sa)
  • PubMed Central (publishedVersion, cc-by-sa)
  • PubMed (publishedVersion)
Funders
Centers for Disease Control and Prevention
Topics
  • Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords
non-alcoholic fatty liver disease, metabolic syndrome, mortality risk, hepatic steatosis, insulin resistance, cardiovascular mortality, liver-related mortality, body mass index, long-term survival
MeSH terms
Adult, Cardiovascular Diseases, Female, Humans, Insulin Resistance, Male, Middle Aged, Nutrition Surveys, Risk Factors, United States, Comorbidity, Body Mass Index, Proportional Hazards Models, Age Distribution, Sex Distribution, Metabolic Syndrome, Non-alcoholic Fatty Liver Disease

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review