The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
PCSK9 inhibition to reduce cardiovascular disease risk: recent findings from the biology of PCSK9
Open accessAbstract
PURPOSE OF REVIEW: Review novel insights into the biology of proprotein convertase subtilisin/kexin 9 (PCSK9) that may explain the extreme efficiency of PCSK9 inhibition and the unexpected metabolic effects resulting from PCSK9 monoclonal antibody therapy, and may identify additional patients as target of therapy. RECENT FINDINGS: For over 20 years, the practical knowledge of cholesterol metabolism has centered around cellular mechanisms, and around the idea that statin therapy is the essential step to control metabolic abnormalities for cardiovascular risk management. This view has been embraced by the recent AHA/ACC guidelines, but is being challenged by recent studies including nonstatin medications and by the development of a new class of cholesterol-lowering agents that seems destined to early US Food and Drug Administration approval. The discovery of PCSK9 - a circulating protein that regulates hepatic low-density lipoprotein (LDL) receptor and serum LDL cholesterol levels - has led to a race for its therapeutic inhibition. Recent findings on PCSK9 regulation and pleiotropic effects will help identify additional patient groups likely to benefit from the inhibitory therapy and unravel the full potential of PCSK9 inhibition therapy. SUMMARY: Injectable human monoclonal antibodies to block the interaction between PCSK9 and LDL receptor are demonstrating extraordinary efficacy (LDL reductions of up to 70%) and almost the absence of any side-effects. A more moderate effect is seen on other lipoprotein parameters, with the exception of lipoprotein(a) levels. We describe mechanisms that can explain the effect on lipoprotein(a), predict a potential effect on postprandial triglyderides, and suggest a new category of patients for anti-PCSK9 therapy.
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“At the same time, convincing data is also available to demonstrate the safety of very low LDL-C levels [17][18][19].”
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Metadata
- Authors
- Tavori, H., Giunzioni, I., & Fazio, S.
- Affiliations
- Oregon Health & Science University (US)
- Corresponding author
- Fazio, Sergio
- Venue
- Current Opinion in Endocrinology, Diabetes & Obesity
- Published
- 2015-04
- Volume
- 22
- Issue
- 2
- Pages
- 126-132
- ISSN
- 1752-296X (ISSN-L)
- PMC
- PMC4384821
- OpenAlex
- W1995025365
- Cited by
- 30
- References
- 78
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 2
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Endocrinology Diabetes and Obesity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL106845)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- PCSK9 inhibition, PCSK9, PCSK9 monoclonal antibodies, LDL cholesterol lowering, LDL receptor, cholesterol metabolism, cardiovascular risk, lipoprotein(a), postprandial triglycerides, pleiotropy, statin therapy, patient selection
- MeSH terms
- Proprotein Convertase 9, Animals, Antibodies, Monoclonal, Hypolipidemic Agents, Cardiovascular Diseases, Humans, Receptors, LDL, Serine Endopeptidases, Signal Transduction, Serine Proteinase Inhibitors, Treatment Outcome, Proprotein Convertases, Dyslipidemias, Lipid Metabolism
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