Cited by 235Diabetes Management and ResearchDiabetes and associated disordersDiabetes Treatment and Management

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Obesity, insulin resistance, and type 1 diabetes mellitus

Polsky, Sarit, Ellis, Samuel L.·2015·Current Opinion in Endocrinology, Diabetes & Obesity

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Abstract

PURPOSE OF REVIEW: To summarize recent studies about obesity, insulin resistance, and type 1 diabetes mellitus (T1DM). RECENT FINDINGS: Overweight and obesity continue to be prevalent among individuals with T1DM. Obesity rates appear to have reached a plateau among children with T1DM in some parts of the world. The risk for development of T1DM is increased by obesity and may occur at an earlier age among obese individuals with a predisposition. Obesity increases the risk for comorbidities among individuals with T1DM, especially metabolic syndrome, and microvascular and macrovascular diseases. Metformin, glucagon-like peptide-1 agonist therapy, sodium glucose cotransporter-2 inhibitor therapy, and bariatric surgery may be beneficial therapies for glucose control, comorbidity management, and obesity among adults with T1DM. Insulin resistance may be improved among obese individuals with T1DM by biguanides (metformin) and glucagon-like peptide-1 agonists (exenatide). SUMMARY: We review the last 18 months of literature on obesity, insulin resistance, and T1DM to highlight new epidemiologic results and treatments.

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Authors: Polsky, S., & Ellis, S. L.
Affiliations: University of Colorado Anschutz (US)
Corresponding author: Polsky, Sarit
ORCID: Polsky, Sarit
Venue: Current Opinion in Endocrinology, Diabetes & Obesity
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2015-08
Volume: 22
Issue: 4
Pages: 277-282
ISSN: 1752-296X (ISSN-L)
DOI: 10.1097/med.0000000000000170
OpenAlex: W2184822581
Cited by: 235
References: 27
Citations by year: 2026: 5 · 2025: 16 · 2024: 29 · 2023: 21 · 2022: 35 · 2021: 27 · 2020: 26 · 2019: 23 · 2018: 21 · 2017: 18 · 2016: 10 · 2015: 4
FWCI: 15.32
Type: journal article
Language: en
Open access: closed
Locations: Current Opinion in Endocrinology Diabetes and Obesity (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: type 1 diabetes, obesity, insulin resistance, childhood obesity, metabolic syndrome, microvascular complications, macrovascular complications, metformin, biguanides, GLP-1 receptor agonists, exenatide, SGLT2 inhibitors, bariatric surgery
MeSH terms: Diabetes Mellitus, Type 1, Humans, Insulin Resistance, Obesity, Comorbidity

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Obesity, insulin resistance, and type 1 diabetes mellitus

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