The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Healthy and unhealthy aging on kidney structure and function: human studies
Open accessAbstract
Purpose of review: This review is intended to provide an up-to-date analysis of the structural and functional alterations of the kidneys that accompany healthy and unhealthy aging in humans. Macro- and micro- structural changes and glomerular filtration rate (whole kidney and single nephron) accompanying aging will be stressed. Recent findings: Comparative findings concerning distribution of anatomic changes of the kidney healthy and unhealthy aging are reviewed. Challenges concerning definition of chronic kidney disease (CKD) in otherwise healthy aging patients are discussed. The complex interactions of CKD and aging are discussed. The role of podocyte dysbiosis in kidney aging is reviewed. Summary: Kidney aging is a complex phenomenon often difficult to distinguish from CKD. Nonetheless, phenotypes of healthy and unhealthy aging are evident. Much more information concerning the molecular characteristics of normal kidney aging and its relevance to chronic kidney disease is needed.
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“Kidney biopsy data from elderly individuals indicate that ageing is associated with a decline in the glomerular filtration rate.250”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [250]
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New creatinine- and cystatin C-based equations to estimate GFR without race
Inker, L. A., Eneanya, N. D., Coresh, J., Tighiouart, H., Wang, D., Sang, Y., Crews, D. C., Doria, A., Estrella, M. M., Froissart, M., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2102953 · Cited by 4,695
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Glomerular hyperfiltration in diabetes: mechanisms, clinical significance, and treatment
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Self-citationThe Association Between Age and Nephrosclerosis on Renal Biopsy Among Healthy Adults
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Self-citationThe Substantial Loss of Nephrons in Healthy Human Kidneys with Aging
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Summary of Recommendation Statements
(2012) · Kidney International Supplements · doi:10.1038/kisup.2012.77 · Cited by 409
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Self-citationKidney Disease as a Driver of Immunosenescence
Song, Z., Tsou, S., Martin, F., Kayumov, M., Xiao, Y., Zhou, H., Abdi, R., & Tullius, S. G. (2025) · Journal of the American Society of Nephrology · doi:10.1681/asn.0000000896 · Cited by 21
Metadata
- Authors
- Denic, A., Rule, A. D., & Glassock, R. J.
- Affiliations
- Department of Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota
- Mayo Clinic (US)
- University of California, Los Angeles (US)
- Venue
- Current Opinion in Nephrology & Hypertension
- Published
- 2022-01-25
- Volume
- 31
- Issue
- 3
- Pages
- 228-234
- ISSN
- 1062-4821 (ISSN-L)
- 1473-6543
- PMC
- PMC9035051
- OpenAlex
- W4207071407
- Cited by
- 20
- References
- 72
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 5 · 2023: 4 · 2022: 1
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Nephrology & Hypertension (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK090358)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Keywords
- kidney aging, healthy aging, chronic kidney disease, glomerular filtration rate, nephron, kidney structure, single nephron glomerular filtration rate
- MeSH terms
- Aging, Female, Glomerular Filtration Rate, Humans, Kidney, Male, Podocytes, Renal Insufficiency, Chronic
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