The Effect of Gluten‐free Diet on Clinical Symptoms and the Intestinal Mucosa of Patients With Potential Celiac Disease
Abstract
In this prospective study, we evaluated the effect of gluten-free diet (GFD) in a cohort of 65 children with potential celiac disease. Patients received GFD for signs/symptoms (N = 47) or parents' choice (N = 18). Most frequent signs/symptoms were low body mass index (36%), recurrent abdominal pain (34%), and diarrhea (19%). Of the 35/47 patients followed-up on GFD, only 54% (19/35) showed a complete clinical response. In 9 of 65 patients an intestinal biopsy was also performed after at least 1 year of GFD. No significant differences were observed in terms of Marsh grade (P = 0.33), lamina propria CD25+ cells (P = 0.80), CD3+ (P = 0.9), and γδ+ (P = 0.59) intraepithelial lymphocytes density and intestinal anti-TG2 deposits (P = 0.60). In conclusion, caution is necessary before attributing all symptoms to gluten in this condition.
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A GFD does not always improve symptoms in potential CD.
“A GFD does not always improve symptoms (141).”
From ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. (2022) · cites this paper as [141]
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Husby, S., Koletzko, S., Korponay‐Szabó, I., Kurppa, K., Mearin, M. L., Ribes‐Koninckx, C., Shamir, R., Troncone, R., Auricchio, R., Castillejo, G., et al. (2020) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000002497 · Cited by 1,255 · see citing works
Self-citationESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease.
Mearin, M. L., Agardh, D., Antunes, H., Al‐toma, A., Auricchio, R., Castillejo, G., Catassi, C., Ciacci, C., Discepolo, V., Dolinsek, J., et al. (2022) · Journal of pediatric gastroenterology and nutrition · doi:10.1097/mpg.0000000000003540 · Cited by 186 · see citing works
Self-citation
- Authors
- Mandile, R., Discepolo, V., Scapaticci, S., Del Vecchio, M. R., Maglio, M. A., Greco, L., Troncone, R., & Auricchio, R.
- Affiliations
- University of Naples Federico II (IT)
- Department of Translational Medical Science (DISMET) Section of Pediatrics University of Naples Federico II Naples Italy
- Corresponding author
- Mandile, Roberta
- ORCID
- Venue
- Journal of Pediatric Gastroenterology and Nutrition
- Publisher
- Wiley
- Published
- 2018-04
- Volume
- 66
- Issue
- 4
- Pages
- 654-656
- ISSN
- 0277-2116 (ISSN-L)
- 1536-4801
- OpenAlex
- W2755323474
- Cited by
- 27
- References
- 0
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 3 · 2019: 6 · 2018: 3
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pediatric Gastroenterology and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
- Health Sciences › Medicine › Surgery › Eosinophilic Esophagitis
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gluten-free diet, celiac disease, children, clinical response, intestinal mucosa, intraepithelial lymphocytes, anti-tissue transglutaminase antibodies, low body mass index, abdominal pain, diarrhea
- MeSH terms
- Adolescent, Celiac Disease, Child, Child, Preschool, Female, Humans, Infant, Intestinal Mucosa, Male, Prospective Studies, Treatment Outcome, Diet, Gluten-Free
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