Cited by 248Neuroblastoma Research and TreatmentsPI3K/AKT/mTOR signaling in cancerNeurofibromatosis and Schwannoma Cases

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PI3King the Lock: Targeting the PI3K/Akt/mTOR Pathway as a Novel Therapeutic Strategy in Neuroblastoma

King, David, Yeomanson, Daniel, Bryant, Helen E.·2015·Journal of Pediatric Hematology/Oncology

DOI 10.1097/mph.0000000000000329

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Abstract

Neuroblastoma is the most common extracranial cancer in childhood. High-risk neuroblastoma continues to have a poor prognosis and there is an urgent need to design biologically based therapies that specifically target the pathways responsible for malignant transformation and progression. One such pathway is the PI3K/Akt/mTOR pathway. In this article we outline the evidence for aberrant activation of the PI3K/Akt/mTOR pathway in neuroblastoma and discuss the possible mechanisms which mediate it. We also discuss the development of treatments targeting this pathway in neuroblastoma and the challenges that must be overcome before such treatments can enter routine clinical practice.

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Authors: King, D., Yeomanson, D., & Bryant, H. E.
Affiliations: Sheffield Children's Hospital (GB)
ORCID: King, David
Bryant, Helen E.
Venue: Journal of Pediatric Hematology/Oncology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2015-05
Volume: 37
Issue: 4
Pages: 245-251
ISSN: 1077-4114 (ISSN-L)
DOI: 10.1097/mph.0000000000000329
OpenAlex: W1974245465
Cited by: 248
References: 52
Citations by year: 2026: 10 · 2025: 19 · 2024: 31 · 2023: 24 · 2022: 26 · 2021: 29 · 2020: 29 · 2019: 25 · 2018: 22 · 2017: 22 · 2016: 11
FWCI: 2.46
Type: journal article
Language: en
Open access: closed
Locations: Journal of Pediatric Hematology/Oncology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Neuroblastoma Research and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Health Sciences › Medicine › Clinical Neurology › Neurofibromatosis and Schwannoma Cases
Keywords: neuroblastoma, PI3K/AKT/mTOR pathway, high-risk neuroblastoma, PI3K inhibitors, AKT inhibitors, mTOR inhibitors, targeted therapy, childhood cancer
MeSH terms: Mechanistic Target of Rapamycin Complex 1, Mechanistic Target of Rapamycin Complex 2, Phosphoinositide-3 Kinase Inhibitors, Animals, Humans, Neuroblastoma, Signal Transduction, Phosphatidylinositol 3-Kinases, Multiprotein Complexes, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-akt, TOR Serine-Threonine Kinases

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PI3King the Lock: Targeting the PI3K/Akt/mTOR Pathway as a Novel Therapeutic Strategy in Neuroblastoma

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