Cited by 86Traumatic Brain Injury ResearchTraumatic Brain Injury and Neurovascular DisturbancesAutomotive and Human Injury Biomechanics

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Regional Neurodegeneration and Gliosis Are Amplified by Mild Traumatic Brain Injury Repeated at 24-Hour Intervals

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Bolton, Amanda N., Saatman, Kathryn E.·2014·Journal of Neuropathology & Experimental Neurology

DOI 10.1097/nen.0000000000000115PMC PMC4170569

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Abstract

Most traumatic brain injuries (TBIs) that occur every year are classified as "mild." Individuals involved in high-risk activities may sustain multiple mild TBIs. We evaluated the acute physiologic and histopathologic consequences of mild TBI in a mouse model, comparing sham injury, single impact, or 5 impacts at a 24- or 48-hour interinjury interval. A single closed skull impact resulted in bilateral gliosis in the hippocampus and entorhinal cortex that was proportional to impact depth. Midline impact, at a depth just above the threshold to induce transient unconsciousness, produced occasional axonal injury and degenerating neurons accompanied by astrogliosis in the entorhinal cortex and cerebellum. Mild TBI repeated every 24 hours resulted in bilateral hemorrhagic lesions in the entorhinal cortex along with significantly increased neurodegeneration and microglial activation despite diminished durations of apnea and unconsciousness with subsequent impacts. Astrogliosis and diffusely distributed axonal injury were also observed bilaterally in the cerebellum and the brainstem. When the interval between mild TBIs was increased to 48 hours, the pathologic consequences were comparable to those of a single TBI. Together, these data suggest that, in mice, the brain remains at an increased risk for damage for 24 hours after mild TBI despite reduced acute physiologic responses to subsequent mild impacts.

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Additional file 1 of Alterations in iron content, iron-regulatory proteins and behaviour without tau pathology at one year following repetitive mild traumatic brain injury
Juan, S. M. A., Daglas, M., Truong, P. H., Mawal, C., & Adlard, P. A. (2023) · Figshare · doi:10.6084/m9.figshare.23706895

Authors: Bolton, A. N., & Saatman, K. E.
Affiliations: University of Kentucky (US)
Corresponding author: Saatman, Kathryn E.
Venue: Journal of Neuropathology & Experimental Neurology
Publisher: Oxford University Press (OUP)
Published: 2014-10
Volume: 73
Issue: 10
Pages: 933-947
ISSN: 0022-3069 (ISSN-L)
1554-6578
DOI: 10.1097/nen.0000000000000115
PMC: PMC4170569
OpenAlex: W2330807792
Cited by: 86
References: 50
Citations by year: 2025: 3 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 8 · 2020: 9 · 2019: 15 · 2018: 10 · 2017: 10 · 2016: 12 · 2015: 7
FWCI: 7.30
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Neuropathology & Experimental Neurology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Neurological Disorders and Stroke (P01NS058484, P30NS051220, T32NS077889)
Topics: Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Physical Sciences › Engineering › Biomedical Engineering › Automotive and Human Injury Biomechanics
Keywords: mild traumatic brain injury, astrocyte activation, microglial activation, axonal injury, entorhinal cortex, hippocampus, cerebellum, hemorrhagic lesions, impact depth, mouse model
MeSH terms: Animals, Brain Injuries, Gliosis, Male, Mice, Inbred C57BL, Nerve Degeneration, Time Factors, Mice

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Regional Neurodegeneration and Gliosis Are Amplified by Mild Traumatic Brain Injury Repeated at 24-Hour Intervals

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