Dendritic Spine Density, Morphology, and Fibrillar Actin Content Surrounding Amyloid-β Plaques in a Mouse Model of Amyloid-β Deposition

Kirkwood, Caitlin M.; Ciuchta, Jennifer; Ikonomovic, Milos D.; Fish, Kenneth N.; Abrahamson, Eric E.; Murray, Patrick S.; Klunk, William E.; Sweet, Robert A.

doi:10.1097/nen.0b013e31829ecc89

Dendritic Spine Density, Morphology, and Fibrillar Actin Content Surrounding Amyloid-β Plaques in a Mouse Model of Amyloid-β Deposition

Dendritic spines are the site of the majority of excitatory synapses, the loss of which correlates with cognitive impairment in patients with Alzheimer disease. Substantial evidence indicates that amyloid-β (Aβ) peptide, either insoluble fibrillar Aβ deposited into plaques or soluble non-fibrilla…