Cerebrospinal Fluid Tau Cleaved by Caspase-6 Reflects Brain Levels and Cognition in Aging and Alzheimer Disease
Open accessAbstract
Caspase-6 (Casp6) activation in the brain is implicated early in the pathogenesis of Alzheimer disease (AD). In view of the need for early AD diagnosis, brain Casp6 activity was investigated by measuring Tau cleaved by Casp6 (TauΔCasp6) protein in postmortem cerebrospinal fluid (CSF) of 7 non-cognitively impaired; 5 mild cognitively impaired; and 12 mild, moderate, and severe AD patients. Levels of TauΔCasp6 in CSF accurately reflected the levels of active Casp6 and TauΔCasp6 detected using immunohistochemistry in hippocampal sections from the same individuals. Levels of CSF TauΔCasp6 significantly correlated with AD severity and with lower Global Cognitive Scores; Mini-Mental State Examination scores; and episodic, semantic, and working memory scores. Regression analyses suggested that the CSF TauΔCasp6 levels combined with TauΔCasp6 brain pathology predict cognitive performance. These results indicate that CSF TauΔCasp6 levels hold promise as a novel early biomarker of AD.
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Tau-402 levels in CSF correlate with cognitive performance in AD patients or aged individuals.
“In addition, tau-402 levels in CSF correlate with cognitive performance in AD patients or aged individuals [199].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [199]
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References 37 · Cited by 47
- Authors
- Ramcharitar, J., Albrecht, S., Afonso, V. M., Kaushal, V., Bennett, D. A., & LeBlanc, A. C.
- Affiliations
- Jewish General Hospital (CA)
- McGill University (CA)
- Rush University Medical Center (US)
- Corresponding author
- LeBlanc, Andrea C.
- Venue
- Journal of Neuropathology & Experimental Neurology
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-09
- Volume
- 72
- Issue
- 9
- Pages
- 824-832
- ISSN
- 0022-3069 (ISSN-L)
- PMC
- PMC3777607
- OpenAlex
- W2078714079
- Cited by
- 47
- References
- 37
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 3 · 2022: 5 · 2021: 8 · 2020: 5 · 2019: 5 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 1 · 2014: 6 · 2013: 1
- FWCI
- 2.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neuropathology & Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Canadian Institutes of Health Research (102238_1)
- National Institute on Aging (P30-AG 10161, R01 AG15819, R01AG015819, P30AG010161)
- National Cancer Institute
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Keywords
- caspase-6, tau cleavage, cerebrospinal fluid biomarkers, Alzheimer's disease, mild cognitive impairment, hippocampus, cognitive impairment, memory, disease severity, aging
- MeSH terms
- Aged, Aged, 80 and over, Aging, Alzheimer Disease, Brain, Cell Line, Transformed, Female, Humans, Male, Mental Status Schedule, Postmortem Changes, Predictive Value of Tests, Recombinant Proteins, Statistics as Topic, Transfection, tau Proteins, Caspase 6, Cognitive Dysfunction
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