The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Tuberous Sclerosis–associated Renal Cell Carcinoma: A Clinicopathologic Study of 57 Separate Carcinomas in 18 Patients
Abstract
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder with characteristic tumors involving multiple organ systems. Whereas renal angiomyolipoma (AML) is common in TSC, renal cell carcinoma (RCC) is rarely reported. Fifty-seven RCCs from 13 female and 5 male TSC patients were reviewed. Age at surgery ranged from 7 to 65 years (mean: 42 y). Nine patients (50%) had multiple synchronous and/or metachronous RCCs (range of 2 to 20 RCCs) and 5 had bilateral RCCs (28%). Seventeen patients (94%) had histologically confirmed concurrent renal AMLs, including 15 with multiple AMLs (88%) and 9 (50%) with AMLs with epithelial cysts. None of the 15 patients with available clinical follow-up information had evidence of distant metastatic disease from 6 to 198 months after their initial surgery (mean: 52 mo). The 57 RCCs exhibited 3 major distinct morphologies: (1) 17 RCCs (30%) had features similar to tumors previously described as "renal angiomyoadenomatous tumor" or "RCC with smooth muscle stroma"; (2) 34 RCCs (59%) showed features similar to chromophobe RCC; and (3) 6 RCCs (11%) showed a granular eosinophilic-macrocystic morphology. Distinct histologic changes were also commonly present in the background kidney parenchyma and included cysts or renal tubules lined by epithelial cells with prominent eosinophilic cytoplasm, nucleomegaly, and nucleoli. Immunohistochemically, all RCCs tested showed strong nuclear reactivity for PAX8 and HMB45 negativity. Compared with sporadic RCCs, TSC-associated RCCs have unique clinicopathologic features including female predominance, younger age at diagnosis, multiplicity, association with AMLs, 3 recurring histologic patterns, and an indolent clinical course. Awareness of the morphologic and clinicopathologic spectrum of RCC in this setting will allow surgical pathologists to better recognize clinically unsuspected TSC patients.
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The Tuberous Sclerosis Complex
Crino, P. B., Nathanson, K. L., & Henske, E. P. (2006) · New England Journal of Medicine · doi:10.1056/nejmra055323 · Cited by 1,793
The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia
Srigley, J. R., Delahunt, B., Eble, J. N., Egevad, L., Epstein, J. I., Grignon, D., Hes, O., Moch, H., Montironi, R., Tickoo, S. K., et al. (2013) · American Journal of Surgical Pathology · doi:10.1097/pas.0b013e318299f2d1 · Cited by 1,047
Delahunt, B., Cheville, J. C., Martignoni, G., et al. (2013) · The American Journal of Surgical Pathology · doi:10.1097/pas.0b013e318299f0fb · Cited by 876
Primary Renal Neoplasms with the ASPL-TFE3 Gene Fusion of Alveolar Soft Part Sarcoma
Argani, P., Antonescu, C. R., Illei, P. B., Lui, M. Y., Timmons, C. F., Newbury, R., Reuter, V. E., Garvin, A. J., Perez-Atayde, A. R., Fletcher, J. A., et al. (2001) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)61684-7 · Cited by 643
Renal manifestations of tuberous sclerosis complex: Incidence, prognosis, and predictive factors
Rakowski, S. K., Winterkorn, E. B., Paul, E., Steele, D. J. R., Halpern, E. F., & Thiele, E. A. (2006) · Kidney International · doi:10.1038/sj.ki.5001853 · Cited by 488
Morphologic and Molecular Characterization of Renal Cell Carcinoma in Children and Young Adults
Bruder, E., Passera, O., Harms, D., Leuschner, I., Ladanyi, M., Argani, P., Eble, J. N., Struckmann, K., Schraml, P., & Moch, H. (2004) · American Journal of Surgical Pathology · doi:10.1097/01.pas.0000131558.32412.40 · Cited by 280
Tuberous sclerosis-associated renal cell carcinoma. Clinical, pathological, and genetic features.
Björnsson, J., Short, M. P., Kwiatkowski, D. J., & Henske, E. P. (1996) · Europe PMC (PubMed Central) · Cited by 243
Al-Saleem, T., Wessner, L. L., Scheithauer, B. W., Patterson, K., Roach, E. S., Dreyer, S. J., Fujikawa, K., Bjornsson, J., Bernstein, J., & Henske, E. P. (1998) · Cancer · doi:10.1002/(sici)1097-0142(19981115)83:10<2208::aid-cncr21>3.0.co;2-k · Cited by 222
Martignoni, G., Pea, M., Bonetti, F., Zamboni, G., Carbonara, C., Longa, L., Zancanaro, C., Maran, M., Brisigotti, M., & Mariuzzi, G. M. (1998) · The American Journal of Surgical Pathology · doi:10.1097/00000478-199806000-00003 · Cited by 178
Rohan, S. M., Xiao, Y., Liang, Y., Dudas, M. E., Al-Ahmadie, H. A., Fine, S. W., Gopalan, A., Reuter, V. E., Rosenblum, M. K., Russo, P., et al. (2011) · Modern Pathology · doi:10.1038/modpathol.2011.80 · Cited by 176
Cited by
Henske, E. P., Jóźwiak, S., Kingswood, J. C., Sampson, J. R., & Thiele, E. A. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.35 · Cited by 831
Trpkov, K., Hes, O., Williamson, S. R., Adeniran, A. J., Agaimy, A., Alaghehbandan, R., Amin, M. B., Argani, P., Chen, Y.-B., Cheng, L., et al. (2021) · Modern Pathology · doi:10.1038/s41379-021-00779-w · Cited by 258
Self-citation
Metadata
- Authors
- Guo, J., Tretiakova, M. S., Troxell, M. L., Osunkoya, A. O., Fadare, O., Sangoi, A. R., Shen, S. S., Lopez-Beltran, A., Mehra, R., Heider, A., Higgins, J. P., Harik, L. R., Leroy, X., Gill, A. J., Trpkov, K., Campbell, S. C., Przybycin, C., Magi-Galluzzi, C., & McKenney, J. K.
- Venue
- American Journal of Surgical Pathology
- Published
- 2014-11
- Volume
- 38
- Issue
- 11
- Pages
- 1457-1467
- ISSN
- 0147-5185 (ISSN-L)
- OpenAlex
- W2023259349
- Cited by
- 296
- References
- 19
- FWCI
- 15.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- Guo, J., Tretiakova, M. S., Troxell, M. L., Osunkoya, A. O., Fadare, O., Sangoi, A. R., Shen, S. S., Lopez-Beltran, A., Mehra, R., Heider, A., Higgins, J. P., Harik, L. R., Leroy, X., Gill, A. J., Trpkov, K., Campbell, S. C., Przybycin, C., Magi-Galluzzi, C., & McKenney, J. K. (2014). Tuberous Sclerosis–associated Renal Cell Carcinoma: A Clinicopathologic Study of 57 Separate Carcinomas in 18 Patients. American Journal of Surgical Pathology. https://doi.org/10.1097/pas.0000000000000248
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
