The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
High Immunohistochemical Expression of TGF-β1 Predicts a Poor Prognosis in Cervical Cancer Patients who Harbor Enriched Endoglin Microvessel Density
Abstract
Endoglin, a coreceptor for transforming growth factor β1 (TGF-β1) in vascular endothelial cells, is highly upregulated in tumor vessels and therefore is a specific biomarker for angiogenesis. Some studies have suggested that assessment of tumor angiogenesis may predict cancer response to chemotherapy and radiotherapy. In this study, we attempted to analyze the immunohistochemical expression of endoglin and TGF-β1 from 80 patients with different International Federation of Gynecology and Obstetrics (FIGO) stages of cervical cancer before they received concurrent chemoradiation and to investigate their prognostic significance. The median follow-up period was 86 months (range, 2-144 months). Endoglin staining was assessed by microvessel density (MVD), whereas TGF-β1 expression was semiquantified as negative, weakly, or strongly staining. A receiver operating characteristic curve was established for endoglin MVD in predicting survival; the optimal cutoff value was 11.125. With a Cox regression analysis, we found that an advanced FIGO stage (hazard ratio 4.66; 95% confidence interval 2.10-10.32, P<0.001) and endoglin MVD more than 11.125 (hazard ratio 12.21; 95% confidence interval 3.62-41.16, P=<0.001) were independent factors to predict survival. Interestingly, a strong TGF-β1 expression was significantly associated with poor survival only when the endoglin MVD value was higher than 10. Our study shows that evaluation of endoglin MVD by immunochemistry can be used as an independent prognostic marker for cervical cancer patients receiving concurrent chemoradiation. TGF-β1 also had an impact on survival only when endoglin MVD was enriched, suggesting its involvement in tumor progression in the later stage of angiogenesis.
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“and interaction between endothelial cells and pericytes confers localized and constitutive TGF-β activation, which is required for microvascular integrity274,275.”
From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [274]
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Cites
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Cited by
TGFβ biology in cancer progression and immunotherapy
Derynck, R., Turley, S. J., & Akhurst, R. J. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0403-1 · Cited by 944
Targeting TGFβ signal transduction for cancer therapy
Liu, S., Ren, J., & ten Dijke, P. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00436-9 · Cited by 413
“A positive correlation between the TGFβ level and microvessel density was observed in various types of tumors.(159) Endothelial cells express two TβRIs (activin receptor-like kinase 1 (ALK1) and TβRI/ALK5).”
Background
Metadata
- Authors
- Lin, H., Huang, C.-C., Ou, Y.-C., Huang, E.-Y., ChangChien, C.-C., Tseng, C.-W., Fu, H.-C., Wu, C.-H., Li, C.-J., & Ma, Y.-Y.
- Affiliations
- Chang Gung University (TW)
- Corresponding author
- Ma, Yen-Ying
- Venue
- International Journal of Gynecological Pathology
- Published
- 2012-09
- Volume
- 31
- Issue
- 5
- Pages
- 482-489
- ISSN
- 0277-1691 (ISSN-L)
- OpenAlex
- W2016020717
- Cited by
- 28
- References
- 23
- Citations by year
- 2025: 2 · 2024: 4 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 1 · 2017: 4 · 2016: 3 · 2015: 4 · 2014: 3 · 2013: 1
- FWCI
- 3.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Gynecological Pathology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- cervical cancer, CD105, TGF-β1, tumor angiogenesis, microvessel density, prognostic factors, survival prediction, FIGO stage, concurrent chemoradiotherapy, tumor progression
- MeSH terms
- Endoglin, Adult, Aged, Uterine Cervical Neoplasms, Female, Humans, Immunohistochemistry, Middle Aged, Prognosis, Receptors, Cell Surface, Antigens, CD, Multivariate Analysis, Platelet Endothelial Cell Adhesion Molecule-1, Transforming Growth Factor beta1
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