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Amifostine Reduces Radiation-Induced Complications in a Murine Model of Expander-Based Breast Reconstruction
Open accessAbstract
BACKGROUND: Immediate expander-based breast reconstruction after mastectomy is a prevalent option for many women with breast cancer. When coupled with adjuvant radiation therapy, however, radiation-induced skin and soft-tissue injury diminish the success of this reconstructive technique. The authors hypothesize that prophylactic administration of the cytoprotectant amifostine will reduce soft-tissue complications from irradiation, aiding expander-based reconstruction. METHODS: Sprague-Dawley rats were divided into two groups: operative expander placement (expander group) and operative sham (sham group). Expander specimens received a sublatissimus tissue expander with a 15-cc fill volume; shams underwent identical procedures without expanders. Experimental groups were further divided into control specimens receiving no further intervention, radiation therapy-only specimens receiving human-equivalent irradiation, and amifostine plus radiation therapy specimens receiving both amifostine and human-equivalent irradiation. After a 45-day recovery period, animals were evaluated grossly and with ImageJ analysis for skin and soft-tissue complications. RESULTS: None of the control, radiation therapy-alone, or amifostine plus radiation therapy sham specimens showed skin and soft-tissue complications. For expander animals, significantly fewer amifostine plus radiation therapy specimens [four of 13 (30 percent)] demonstrated skin and soft-tissue complications compared with radiation therapy-alone specimens [nine of 13 (69 percent); p = 0.041]. ImageJ evaluation of expander specimens demonstrated a significant increase in skin and soft-tissue necrosis for radiation therapy-alone specimens (12.94 percent) compared with animals receiving amifostine plus radiation therapy (6.96 percent) (p = 0.019). CONCLUSIONS: Amifostine pretreatment significantly reduced skin and soft-tissue complications. These findings demonstrate that amifostine prophylaxis provides protection against radiation-induced skin and soft-tissue injury in a murine model of expander-based breast reconstruction.
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“Inadequately controlled acute pain and excessive opioid use delay recovery and hospital discharge after many surgeries.53–56”
From Chronic postsurgical pain: From risk factor identification to multidisciplinary management at the Toronto General Hospital Transitional Pain Service (2019) · cites this paper as [53]
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References 14 · Cited by 14
Metadata
- Authors
- Felice, P. A., Nelson, N. S., Page, E. E., Deshpande, S. S., Donneys, A., Rodriguez, J., & Buchman, S. R.
- Affiliations
- University of South Carolina (US)
- Venue
- Plastic and Reconstructive Surgery
- Published
- 2014-10
- Volume
- 134
- Issue
- 4
- Pages
- 551e-560e
- ISSN
- 0032-1052 (ISSN-L)
- PMC
- PMC4217130
- OpenAlex
- W2328625710
- Cited by
- 14
- References
- 14
- Citations by year
- 2023: 1 · 2022: 1 · 2020: 1 · 2019: 3 · 2018: 3 · 2016: 2 · 2015: 3
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Plastic & Reconstructive Surgery (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA125187)
- Topics
- Health Sciences › Medicine › Surgery › Breast Implant and Reconstruction
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Health Sciences › Medicine › Dermatology › Chemotherapy-related skin toxicity
- Keywords
- amifostine, radiation dermatitis, adjuvant radiotherapy, breast cancer, cytoprotection, soft tissue necrosis, prophylaxis, tissue expanders, mastectomy
- MeSH terms
- Animals, Amifostine, Male, Radiation Injuries, Radiation-Protective Agents, Tissue Expansion, Mammaplasty, Rats, Sprague-Dawley, Models, Animal, Rats
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- CoChat. (2026). Citation check: Amifostine Reduces Radiation-Induced Complications in a Murine Model of Expander-Based Breast Reconstruction. https://app.cochat.ai/papers/10.1097/prs.0000000000000543
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- Felice, P. A., Nelson, N. S., Page, E. E., Deshpande, S. S., Donneys, A., Rodriguez, J., & Buchman, S. R. (2014). Amifostine Reduces Radiation-Induced Complications in a Murine Model of Expander-Based Breast Reconstruction. Plastic and Reconstructive Surgery. https://doi.org/10.1097/prs.0000000000000543
