The Potential Use of Novel Plant-Derived Recombinant Human Collagen in Aesthetic Medicine
Abstract
Summary: Recombinant human type I collagen, identical in structure and functionality to human type I collagen, was successfully expressed and extracted from genetically modified tobacco plants. Contrarily to tissue extracted protein, rhCollagen is not immunogenic and not allergenic and has an intact triple helix structure showing superior biological functionality. A photocurable rhCollagen was developed by chemically modifying the protein to allow cross-linking under illumination at various wavelengths, maintaining the protein structural and biological functions. The use of the photocurable rhCollagen in aesthetic medicine, especially as a dermal filler and as a bioink for 3D-printed breast implant is discussed in this article.
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Collagen mimetic peptides and recombinant human collagen offer reduced immunogenicity and antigenicity compared to animal-derived collagen.
“Collagen mimetic peptides (CMPs) and recombinant human collagen (rhCollagen) offer the benefit of reduced immunogenicity and antigenicity compared to animal-derived collagen, making them less likely to provoke immune responses [37,38,39].”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [37]
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Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering
Fazel Anvari-Yazdi, A., Badea, I., & Chen, X. (2025) · Gels · doi:10.3390/gels11060441 · Cited by 20 · see citing works
- Authors
- Seror, J., Stern, M., Zarka, R., & Orr, N.
- Affiliations
- From CollPlant Ltd.
- Venue
- Plastic & Reconstructive Surgery
- Published
- 2021-11-29
- Volume
- 148
- Issue
- 6S
- Pages
- 32S-38S
- ISSN
- 0032-1052 (ISSN-L)
- OpenAlex
- W3216179868
- Cited by
- 22
- References
- 0
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 5 · 2023: 6 · 2022: 2
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Plastic & Reconstructive Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Transgenic Plants and Applications
- Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
- Keywords
- protein cross-linking, dermal fillers, bioinks, aesthetic medicine, immunogenicity, triple helix
- MeSH terms
- Dermal Fillers, Esthetics, Humans, Plant Extracts, Prosthesis Design, Recombinant Proteins, Nicotiana, Skin Aging, Breast Implants, Collagen Type I, Printing, Three-Dimensional
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