Psychological therapy for centralized pain: an integrative assessment and treatment model
Open accessAbstract
Objective: Chronic pain is a significant health problem that is increasing in prevalence, and advances in treatment are needed. Methods: We briefly review the leading evidence-based psychological therapies for chronic pain—cognitive-behavioral and acceptance/mindfulness-based therapies—and examine several limitations and missing perspectives of these approaches. We review six lesser-known interventions that address these limitations, and we describe our integrative model for psychological assessment and treatment of centralized pain. We present a typical patient and describe how we apply this approach, along with challenges to its implementation and possible solutions to these challenges. Results: Greater pain treatment efficacy may be possible if clinicians: ( a ) distinguish patients with primarily centralized (i.e., somatoform or nociplastic) pain from those with primarily peripheral (nociceptive, inflammatory, or neuropathic) pain; ( b ) acknowledge the capacity of the brain not only to modulate pain but also generate as well as attenuate or eliminate centralized pain; ( c ) consider the powerful role that adverse life experiences and psychological conflicts play in centralized pain; and ( d ) integrate emotional processing and interpersonal changes into treatment. Our integrative treatment involves delivering a progression of interventions, as needed, to achieve pain reduction: tailored pain neuroscience education, cognitive and mindfulness skills to decrease the pain danger alarm mechanism, behavioral engagement in avoided painful and other feared activities, emotional awareness and expression to reverse emotional avoidance and overcome trauma or psychological conflict, and adaptive communication to decrease interpersonal stress. Conclusions: This integrative assessment and treatment model has the potential to substantially reduce and sometimes eliminate centralized pain by changing the cognitive, behavioral, emotional, and interpersonal processes that trigger and maintain centralized pain.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Psychotherapies focusing on early life adverse experiences, unexplored conflicting emotions and beliefs, and their effect on current and future behaviour are relatively undeveloped in chronic pain management but trials are now emerging.
“They are relatively undeveloped in chronic pain management but trials are now emerging (Lumley 2019).”
From Psychological therapies for the management of chronic pain (excluding headache) in adults (2020) · cites this paper as Lumley 2019
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
No citation lists for this paper
No citation lists for this paper yet — checked again daily.
References 95 · Cited by 116
Research works printed but not linked: 74
- [1]Merskey H Pain terms: a list with definitions and notes on usage. Recommended by the IASP subcommittee on taxonomy. Pain 1979; 6: 249– 52. 460932
- [2]APA. Diagnostic and statistical manual of mental disorders (4th ed., Text Revision) Washigton, DC: American Psychiatric Association Press; 2000.
- [4]APA. Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: American Psychiatric Association Press; 2013.
- [6]Council NR. Relieving pain in America: A blueprint for transforming prevention, care, education, and tesearch Washington, DC: The National Academies Press; 2011. 22553896
- [7]Vowles KE, McEntee ML, Julnes PS, Frohe T, Ney JP, van der Goes DN. Rates of opioid misuse, abuse, and addiction in chronic pain: a systematic review and data synthesis. Pain 2015; 156: 569– 76. 25785523
- [8]Morales-Espinoza EM, Kostov B, Salami DC, Perez ZH, Rosalen AP, Molina JO, Paz LG, Momblona JMS, Areu JB, Brito-Zeron P, Ramos-Casais M, Siso-Almirall A. Complexity, comorbidity, and health care costs associated with chronic widespread pain in primary care. Pain 2016; 157: 818– 26. 26645546
- [9]Deyo RA, Mirza SK, Turner JA, Martin BI. Overtreating chronic back pain: Time to back off? J Am Board Fam Med 2009; 22: 62– 8. 19124635 PMC2729142
- [18]Morley S, Williams A, Eccleston C. Examining the evidence about psychological treatments for chronic pain: Time for a paradigm shift? Pain 2013; 154: 1929– 31. 23742793
- [19]Clauw DJ. Diagnosing and treating chronic musculoskeletal pain based on the underlying mechanism(s). Best Pract Res Clin Rheumatol 2015; 29: 6– 19. 26266995
- [20]Kosek E, Cohen M, Baron R, Gebhart GF, Mico J-A, Rice ASC, Rief W, Sluka AK. Do we need a third mechanistic descriptor for chronic pain states? Pain 2016; 157: 1382– 6. 26835783
- [21]Yunus MB. Central sensitivity syndromes: A new paradigm and group nosology for fibromyalgia and overlapping conditions, and the related issue of disease versus illness. Semin Arthritis Rheum 2008; 37: 339– 52. 18191990
- [22]Brinjikji W, Luetmer PH, Comstock B, Bresnahan BW, Chen LE, Deyo RA, Halabi S, Turner JA, Avins AL, James K, Wald JT, Kallmes DF, Jarvik JG. Systematic literature review of imaging features of spinal degeneration in asymptomatic populations. Am J Neuroradiol 2015; 36: 811– 6. 25430861 PMC4464797
- [23]Deyo RA, Rainville J, Kent DL. What can the history and physical examination tell us about low back pain? JAMA 1992; 268: 760– 5. 1386391
- [25]Lane RD, Waldstein SR, Critchley HD, Derbyshire SWG, Drossman DA, Wager TD, Schneiderman N, Chesney MA, Jennings JR, Lovallo WR, Rose RM, Thayer JF, Cameron OG. The rebirth of neuroscience in psychosomatic medicine, Part II: clinical applications and implications for research. Psychosom Med 2009; 71: 135– 51. 19196806
- [26]Hashmi JA, Baliki MN, Huang L, Baria AT, Torbey S, Hermann KM, Schnitzer TJ, Apkarian AV. Shape shifting pain: chronification of back pain shifts brain representation from nociceptive to emotional circuits. Brain 2013; 136: 2751– 68. 23983029 PMC3754458
- [28]Coleshill MJ, George DN, Mazzoni G. Placebo analgesia from a rubber hand. J Pain 2017; 18: 1067– 77. 28455248
- [29]Zaki J, Wager TD, Singer T, Keysers C, Gazzola V. The Anatomy of suffering: Understanding the relationship between nociceptive and empathic pain. Trends Cog Sciences 2016; 20: 249– 59. PMC5521249 26944221
- [30]Derbyshire SWG, Whalley MG, Stenger VA, Oakley DA. Cerebral activation during hypnotically induced and imagined pain. NeuroImage 2004; 23: 392– 401. 15325387
- [31]Van den Bergh O, Witthöft M, Petersen S, Brown RJ. Symptoms and the body: Taking the inferential leap. Neurosci Biobehav Rev 2017; 74: 185– 203. 28108416
- [32]Barrett LF, Simmons WK. Interoceptive predictions in the brain. Nat Rev Neurosci 2015; 16: 419– 29. 26016744 PMC4731102
- [34]Tabor AA. Embodied pain-negotiating the boundaries of possible action. Pain 2017; 158: 1007– 11. 28195855
- [35]Gracely RH, Schweinhardt P. Programmed symptoms: disparate effects united by purpose. Curr Rheumatol Rev 2015; 11: 116– 30. 26088212 PMC4997946
- [36]Varinen A, Kosunen E, Mattila K, Koskela T, Sumanen M. The relationship between childhood adversities and fibromyalgia in the general population. J Psychosom Res 2017; 99: 137– 42. 28712419
- [37]Generaal E, Vogelzangs N, Macfarlane GJ, Geenen R, Smit JH, EJCN de Geus, BWJH Penninx, Dekker J. Biological stress systems, adverse life events and the onset of chronic multisite musculoskeletal pain: a 6-year cohort study. Ann Rheum Dis 2016; 75: 847– 54. 25902791
- [38]Nicol AL, Sieberg CB, Clauw DJ, Hassett AL, Moser SE, Brummett CM. The association between a history of lifetime traumatic events and pain severity, physical function, and affective distress in patients with chronic pain. J Pain 2016; 17: 1334– 48. 27641311
- [40]Van Houdenhove B, Luyten P, Tiber Egle U. Stress as a key concept in chronic widespread pain and fatigue disorders. J Musculoskel Pain 2009; 17: 390– 9.
- [41]Landa A, Peterson BS, Fallon BA. Somatoform Pain: A developmental theory and translational research review. Psychosom Med 2012; 74: 717– 27. 22929064 PMC4272574
- [42]Sachs-Ericsson NJ, Sheffler JL, Stanley IH, Piazza JR, Preacher KJ. When emotional pain becomes physical: Adverse childhood experiences, pain, and the role of mood and anxiety disorders. J Clin Psychol 2017; 73: 1403– 28. 28328011 PMC6098699
- [43]Luyten P, Van Houdenhove B, Lemma A, Target M, Fonagy P. Vulnerability for functional somatic disorders: A contemporary psychodynamic approach. J Psychother Integr 2013; 23: 250– 62.
- [44]Kross E, Berman MG, Mischel W, Smith EE, Wager TD. Social rejection shares somatosensory representations with physical pain. Proc Natl Acad Sci 2011; 108: 6270– 5. 21444827 PMC3076808
- [45]Eisenberger NI, Lieberman MD. Why rejection hurts: a common neural alarm system for physical and social pain. Trends Cog Sci 2004; 8: 294– 300. 15242688
- [46]Lane RD, Waldstein SR, Chesney MA, Jennings JR, Lovallo WR, Kozel PJ, Rose RM, Drossman DA, Schneiderman N, Thayer JF, Cameron OG. The rebirth of neuroscience in psychosomatic medicine, Part I: historical context, methods, and relevant basic science. Psychosom Med 2009; 71: 117– 34. 19196808
- [48]Lane RD, Ryan L, Nadel L, Greenberg L. Memory reconsolidation, emotional arousal, and the process of change in psychotherapy: New insights from brain science. Behav Brain Sci 2015; 38: e1. 24827452
- [50]Foa EB, Kozak MJ. Emotional processing of fear: exposure to corrective information. Psychol Bull 1986; 99: 20– 35. 2871574
- [52]Schubiner H, Betzold M. Unlearn your pain: A 28-day process to reprogram your brain 3rd Edition ed. Pleasant Ridge, MI: Mind-Body Pubishing; 2016.
- [54]Selfridge N, Peterson F. Freedom from fibromyalgia: The 5 week program proven to conquer pain New York, New York: Three Rivers Press; 2001.
- [55]Hanscom D Back in control: A surgeon’s roadmap out of chronic pain, 2nd Edition. Seattle, WA: Vertus Press; 2017.
- [56]Shires A, Cayoun B, Simmons A. Immediate and lasting chronic pain reduction following a brief self-implemented mindfulness-based interoceptive exposure task: a pilot study Mindfulness in press.
- [57]Yoshino A, Okamoto Y, Okada G, Takamura M, Ichikawa N, Shibasaki C, Yokoyama S, Doi M, Jinnin R, Yamashita H, Horikoshi M, Yamawaki S. Changes in resting-state brain networks after cognitive–behavioral therapy for chronic pain. Psychol Med 2017: 1– 11. 28893330
- [60]Louw A, Diener I, Butler DS, Puentedura EJ. The effect of neuroscience education on pain, disability, anxiety, and stress in chronic musculoskeletal pain. Arch Phys Med Rehab 2011; 92: 2041– 56. 22133255
- [62]Burger AJ, Lumley MA, Carty JN, Latsch DV, Thakur ER, Hyde-Nolan ME, Hijazi AM, Schubiner H. The effects of a novel psychological attribution and emotional awareness and expression therapy for chronic musculoskeletal pain: A preliminary, uncontrolled trial. J Psychosom Res 2016; 81: 1– 8. PMC4724386 26800632
- [64]Vlaeyen J, Linton S. Fear‐avoidance model of chronic musculoskeletal pain: 12 years on. Pain 2012; 153: 1144– 7. 22321917
- [65]Vlaeyen J, Morley S, Linton SJ, Boersma K, de Jong J. Pain-related fear: exposure based treatment for chronic pain Seattle, WA: IASP Press; 2012.
- [67]Linton SJ, Flink IK, Schrooten MGS, Wiksell R. Understanding co-occurring emotion and pain: The role of context sensitivity from a transdiagnostic perspective. J Contemp Psychother 2016; 46: 1– 9.
- [69]Lumley MA, Leisen JCC, Partridge RT, Meyer TM, Radcliffe AM, Macklem DJ, Naoum LA, Cohen JL, Lasichak LM, Lubetsky MR, Mosley-Williams AD, Granda JL. Does emotional disclosure about stress improve health in rheumatoid arthritis? Randomized, controlled trials of written and spoken disclosure. Pain 2011; 152: 866– 77. 21315515 PMC3065513
- [70]Keefe FJ, Anderson T, Lumley M, Caldwell D, Stainbrook D, Mckee D, Waters SJ, Connelly M, Affleck G, Pope MS, Weis M, Riordan PA, Uhlin BD. A randomized, controlled trial of emotional disclosure in rheumatoid arthritis: Can clinician assistance enhance the effects? Pain 2008; 137: 164– 72. 17923329 PMC2516446
- [72]Smyth JM, Stone AA, Hurewitz A, Kaell A. Effects of writing about stressful experiences on symptom reduction in patients with asthma or rheumatoid arthritis: A randomized trial. JAMA 1999; 281: 1304– 9. 10208146
- [73]Broderick JE, Stone AA, Smyth JM, Kaell AT. The feasibility and effectiveness of an expressive writing intervention for rheumatoid arthritis via home-based videotaped instructions. Ann Behav Med 2004; 27: 50– 9. 14979863
- [74]Gillis ME, Lumley MA, Mosley-Williams A, Leisen JCC, Roehrs T. The health effects of at-home written emotional disclosure in fibromyalgia: a randomized trial. Ann Behav Med 2006; 32: 135– 46. 16972811 PMC2935262
- [75]Broderick JE, Junghaenel DU, Schwartz JE. Written emotional expression produces health benefits in fibromyalgia patients. Psychosom Med 2005; 67: 326– 34. 15784801
- [76]Norman SA, Lumley MA, Dooley JA, Diamond MP. For whom does it work? Moderators of the effects of written emotional disclosure in a randomized trial among women with chronic pelvic pain. Psychosom Med 2004; 66: 174– 83. 15039501
- [77]Graham J, Lobel M, Glass P, Lokshina I. Effects of written anger expression in chronic pain patients: making meaning from pain. J Behav Med 2008; 31: 201– 12. 18320302
- [78]Pepe L, Milani R, Di Trani M, Di Folco G, Lanna V, Solano L. A more global approach to musculoskeletal pain: Expressive writing as an effective adjunct to physiotherapy. Psychol Health Med 2014; 19: 687– 97. 24251961
- [79]Lumley MA, Sklar ER, Carty JN. Emotional disclosure interventions for chronic pain: from the laboratory to the clinic. Translat Behav Med 2012; 2: 73– 81. PMC3419371 22905067
- [80]Gerhardt A, Leisner S, Hartmann M, Janke S, Seidler GH, Eich W, Tesarz J. Eye movement desensitization and reprocessing vs. treatment-as-usual for non-specific chronic back pain patients with psychological trauma: A randomized controlled pilot study. Front Psychiatry 2016; 7: 10. 28066274 PMC5167699
- [81]Tesarz J, Janke S, Leisner S, Seidler G, Eich W, Gerhardt A. Eye movement desensitization and reprocessing in non-specific chronic back pain: a case series. OA Musculoskel Med 2014; 2: 20.
- [82]Lumley MA, Cohen JL, Stout RL, Neely LC, Sander LM, Burger AJ. An emotional exposure-based treatment of traumatic stress for people with chronic pain: Preliminary results for fibromyalgia syndrome. Psychother Theory Res Prac Train 2008; 45: 165– 72. PMC2929968 20808734
- [83]Abbass A Reaching through resistance: Advancing psychotherapy techniques Kansas City, MO: Seven Leaves Press; 2015.
- [84]Chavooshi B, Saberi M, Tavallaie SA, Sahraei H. Psychotherapy for medically unexplained pain: a randomized clinical trial comparing intensive short-term dynamic psychotherapy and cognitive-behavior therapy. Psychosom 2017; 58: 506– 18. 28279495
- [86]Baldoni F, Baldaro B, Trombini G. Psychotherapeutic perspectives in urethral syndrome. Stress Med 1995; 11: 79– 84.
- [87]Abbass A, Lovas D, Purdy A. Direct diagnosis and management of emotional factors in chronic headache patients. Cephalalgia 2008; 28: 1305– 14. 18771494
- [88]Abbass A Somatization: Diagnosing it sooner through emotion-focused interviewing. J Fam Pract 2005; 54: 231– 9. 15755376
- [89]Pascual-Leone A, Greenberg LS. Emotional processing in experiential therapy: Why “the only way out is through.” J Consult Clin Psychol 2007; 75: 875– 87. 18085905
- [91]Hackmann A Imagery rescripting in posttraumatic stress disorder. Cog Behav Pract 2011; 18: 424– 32.
- [92]Lumley MA, Schubiner H, Lockhart NA, Kidwell KM, Harte S, Clauw DJ, Williams DA. Emotional awareness and expression therapy, cognitive-behavioral therapy, and education for fibromyalgia: A cluster-randomized controlled trial. Pain 2017; 158: 2354– 63. 28796118 PMC5680092
- [93]Thakur ER, Holmes HJ, Lockhart NA, Carty JN, Ziadni MS, Doherty HK, Lackner JM, Schubiner H, Lumley MA. Emotional awareness and expression training improves irritable bowel syndrome: A randomized controlled trial. Neurogastroenterol Motil 2017; 12: e13143. PMC5690851 28643436
- [94]Slavin-Spenny O, Lumley M, Thakur E, Nevedal D, Hijazi A. Effects of anger awareness and expression training versus relaxation training on headaches: A randomized trial. Ann Behav Med 2013; 46: 181– 92. 23620190 PMC3778035
- [95]Ziadni MS, Carty JN, Doherty HK, Porcerelli JH, Rapport LJ, Schubiner H, Lumley MA. A life-stress, emotional awareness and expression interview for primary care patients with medically unexplained symptoms: A randomized controlled trial. Health Psychol 2018; 37: 282– 90. 29154608 PMC5848463
- [96]Carty JN, Ziadni MS, Holmes HJ, Tomakowsky J, Peters K, Schubiner H, Lumley MA. The effects of a life-stress, emotional awareness and expression interview for women with chronic urogenital pain: A randomized controlled trial. Pain Med; in press. PMC6611525 30252113
- [97]Abbass A, Schubiner H. Hidden from view. Pleasant Ridge, MI: Psychophysiologic Press; 2018.
- [98]Nijs J, Torres-Cueco R, van Wilgen P, Lluch Girbés E, Struyf F, Roussel N, Van Oosterwijck J, Daenen L, Kuppens K, Vanderweeen L, Hemans L, Beckwee D, Voogt L, Clark J, Mononey N, Meeus M. Applying modern pain neuroscience in clinical practice: criteria for the classification of central sensitization pain. Pain Physician 2014; 17: 447– 57. 25247901
- [99]Williams DA. Phenotypic features of central sensitization. J Appl Biobehav Res 2018; 23: e12135. 30479469 PMC6251410
- [100]Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Häuser W, Katz RS, Mease P, Russell AS, Russell IJ, Winfield JB. Fibromyalgia criteria and severity scales for clinical and epidemiological studies: a modification of the ACR preliminary diagnostic criteria for fibromyalgia. J Rheumatol 2011; 38: 1113– 22. 21285161
- [102]Mayer TG, Neblett R, Cohen H, Howard KJ, Choi YH, Williams MJ, Perez Y, Gatchel RJ. The development and psychometric validation of the Central Sensitization Inventory. Pain Practice 2012; 12: 276– 85. 21951710 PMC3248986
- Authors
- Lumley, M. A., & Schubiner, H.
- Affiliations
- Wayne State University (US)
- Ascension (US)
- Corresponding author
- Lumley, Mark A.
- Venue
- Psychosomatic Medicine
- Published
- 2019-02
- Volume
- 81
- Issue
- 2
- Pages
- 114-124
- ISSN
- 0033-3174 (ISSN-L)
- 1534-7796
- PMC
- PMC6355353
- OpenAlex
- W2901480911
- Cited by
- 116
- References
- 95
- Citations by year
- 2026: 22 · 2025: 21 · 2024: 10 · 2023: 18 · 2022: 17 · 2021: 11 · 2020: 9 · 2019: 8
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychosomatic Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR057808)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- chronic pain, psychotherapy, nociplastic pain, somatoform pain, pain neuroscience education, cognitive behavioral therapy, emotional avoidance, trauma, interpersonal stress, pain assessment
- MeSH terms
- Humans, Psychotherapy, Chronic Pain
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review