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Cited by 137Hepatitis C virus researchHIV, Drug Use, Sexual RiskHIV/AIDS Research and Interventions

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

MSM starting preexposure prophylaxis are at risk of hepatitis C virus infection.

Open access
Hoornenborg, Elske, Achterbergh, Roel C.A., Schim van der Loeff, Maarten F., Davidovich, Udi, Hogewoning, Arjan, de Vries, Henry J.C., Schinkel, Janke, Prins, Maria, van de Laar, Thijs J.W.·2017·AIDS
DOI 10.1097/qad.0000000000001522
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Abstract

OBJECTIVES AND DESIGN: Hepatitis C virus (HCV) has been recognized as an emerging sexually transmitted infection (STI) among HIV-positive MSM. However, HIV-negative MSM at high risk for HIV might also be at increased risk for HCV. We studied the HCV prevalence in HIV-negative MSM who start preexposure prophylaxis (PrEP) in Amsterdam. Phylogenetic analysis was used to compare HCV strains obtained from HIV-negative and HIV-positive MSM. METHODS: At enrolment in the Amsterdam PrEP demonstration project, HIV-negative MSM were tested for the presence of HCV antibodies and HCV RNA. If positive for HCV RNA, an HCV NS5B gene fragment (709 bp) was sequenced and compared with HCV isolates from HIV-positive MSM (n = 223) and risk groups other than MSM (n = 153), using phylogenetic analysis. RESULTS: Of 375 HIV-negative MSM enrolled in Amsterdam PrEP, 18 (4.8%, 95% confidence interval 2.9-7.5%) of participants were anti-HCV and/or HCV RNA positive at enrolment; 15 of 18 (83%) had detectable HCV RNA. HCV genotyping showed genotype 1a (73%), 4d (20%), and 2b (7%). All HCV-positive MSM starting PrEP were part of MSM-specific HCV clusters containing MSM with and without HIV. CONCLUSION: HCV prevalence among HIV-negative MSM who started PrEP was higher than previously reported. All HIV-negative HCV-positive MSM were infected with HCV strains already circulating among HIV-positive MSM. The increasing overlap between sexual networks of HIV-positive and HIV-negative MSM might result in an expanding HCV-epidemic irrespective of HIV-status. Hence, routine HCV testing should be offered to MSM at high risk for HIV, especially for those enrolling in PrEP programs.

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Crossref · 10.1097/qad.0000000000001522

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Metadata

Authors
Hoornenborg, E., Achterbergh, R. C. A., Schim van der Loeff, M. F., Davidovich, U., Hogewoning, A., de Vries, H. J. C., Schinkel, J., Prins, M., & van de Laar, T. J. W.
Affiliations
  • Amsterdam UMC Location University of Amsterdam (NL)
  • GGD Amsterdam (NL)
Corresponding author
Prins, Maria
ORCID
Venue
AIDS
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2017-07-17
Volume
31
Issue
11
Pages
1603-1610
ISSN
0269-9370 (ISSN-L)
DOI
10.1097/qad.0000000000001522
OpenAlex
W2611595043
Cited by
137
References
35
Citations by year
2026: 2 · 2025: 5 · 2024: 4 · 2023: 13 · 2022: 9 · 2021: 10 · 2020: 23 · 2019: 32 · 2018: 31 · 2017: 8
FWCI
15.86
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • AIDS (publishedVersion)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Rivm Repository (Netherlands National Institute for Public Health and the Environment) (submittedVersion)
  • Rivm (National Institute for Public Health and the Environment) (submittedVersion)
Funders
  • Gilead Sciences (CO‐NL‐276‐4222, PA-HIV-PREP-16-0024, CO-US-276-1712)
  • ViiV Healthcare (3000747780, 3000268822)
  • ZonMw (522002003)
Topics
  • Health Sciences › Medicine › Hepatology › Hepatitis C virus research
  • Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Keywords
hepatitis C virus, men who have sex with men, pre-exposure prophylaxis, HIV-negative MSM, HCV prevalence, HCV genotyping, sexual networks, HCV screening
MeSH terms
Adult, Genotype, Hepatitis C, HIV Seropositivity, Humans, Longitudinal Studies, Male, Netherlands, Patient Acceptance of Health Care, Phylogeny, Prospective Studies, Risk Factors, Prevalence, Hepacivirus, HIV Seronegativity, Homosexuality, Male, Hepatitis C Antibodies, Unsafe Sex, Pre-Exposure Prophylaxis

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