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Cited by 32Cervical Cancer and HPV ResearchColorectal and Anal CarcinomasHIV/AIDS Research and Interventions

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

The role of oncogenic human papillomavirus determination for diagnosis of high-grade anal intraepithelial neoplasia in HIV-infected MSM.

Burgos, Joaquin, Hernández-Losa, Javier, Landolfi, Stefania, Guelar, Ana, Dinares, MªCarmen, Villar, Judith, Navarro, Jordi, Ribera, Esteve, Falcó, Vicenç, Curran, Adria·2017·AIDS
DOI 10.1097/qad.0000000000001605
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Abstract

OBJECTIVE: To assess the oncogenic human papillomavirus (HPV) determination and the cotesting HPV and anal cytology value to detect high-grade anal intraepithelial neoplasia (HGAIN) in a cohort of HIV-MSM. DESIGN AND METHODS: Prospective study of HIV-infected MSM who underwent screening for anal dysplasia. Screening program includes anal cytology, HPV testing, and high-resolution anoscopy (HRA) at each visit. Histological samples were obtained if suspicious lesions were revealed by HRA. Sensitivity and specificity of the different tests were calculated by using histological results of HRA-guided biopsy as the reference test for HGAIN diagnosis. RESULTS: From May 2009 to August 2016, 692 HIV-infected MSM underwent 1827 anal cytologies, 1841 HRA examinations, and 1607 HPV testing. At first screening visit, anal cytology results were abnormal in 418 (60.4%) of 692 patients, and oncogenic HPV genotypes were found in 482 (79.5%) of 606 patients. Anal cytology showed a sensitivity of 89.2% [95% confidence interval (CI); 80.7-94.2] and a specificity of 44.2% (95% CI; 40.2-48.2) to detect HGAIN. Oncogenic HPV testing had 90.4% sensitivity (95% CI; 82-86.8) and 24.4% specificity (95% CI; 20.8-28.3). Cotesting showed a 97.4% sensitivity (95% CI; 91-99.3) and 14% specificity (95% CI; 11.2-17.3). In patients with atypical squamous cells of uncertain significance on cytology, oncogenic HPV testing had 91.3% sensitivity and 28.3% specificity to detect HGAIN. CONCLUSION: Abnormal cytology and oncogenic HPV determination showed similar sensitivity for detecting HGAIN. The two tests used together improved the sensitivity but with lowered specificity. In our opinion, HPV testing does not improve HGAIN detection and should not replace anal cytology as a standard screening test for HIV-infected MSM.

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Crossref · 10.1097/qad.0000000000001605

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Metadata

Authors
Burgos, J., Hernández-Losa, J., Landolfi, S., Guelar, A., Dinares, M., Villar, J., Navarro, J., Ribera, E., Falcó, V., & Curran, A.
Affiliations
  • Vall d'Hebron Institut de Recerca (ES)
  • Universitat Autònoma de Barcelona (ES)
ORCID
Venue
AIDS
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2017-10-23
Volume
31
Issue
16
Pages
2227-2233
ISSN
0269-9370 (ISSN-L)
DOI
10.1097/qad.0000000000001605
OpenAlex
W2736847213
Cited by
32
References
25
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 5
FWCI
3.21
Type
journal article
Language
en
Open access
closed
Locations
  • AIDS (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
  • Health Sciences › Medicine › Surgery › Colorectal and Anal Carcinomas
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Keywords
oncogenic human papillomavirus, high-grade anal intraepithelial neoplasia, HIV-infected men who have sex with men, anal cytology, HPV testing, high-resolution anoscopy, atypical squamous cells of uncertain significance, screening sensitivity and specificity
MeSH terms
Adult, Anus Neoplasms, Diagnostic Tests, Routine, Female, Humans, Male, Middle Aged, Prospective Studies, Sensitivity and Specificity, HIV Infections, Homosexuality, Male, Papillomaviridae, Squamous Intraepithelial Lesions of the Cervix

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