The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
No evidence of increased risk of thyroid dysfunction in well treated people living with HIV
Abstract
OBJECTIVES: Possible effects of HIV on thyroid function in the modern combination antiretroviral therapy (cART) era are largely unknown. We aimed to investigate the prevalence and associated risk factors of thyroid dysfunction in well treated people living with HIV (PLWH) and matched uninfected controls and to examine whether HIV is independently associated with thyroid dysfunction. DESIGN AND METHODS: Thyroid-stimulating hormone (TSH), free thyroxine, total thyroxine, and free triiodothyronine were measured in 826 PLWH from the Copenhagen co-morbidity in HIV infection (COCOMO) Study and in 2503 matched uninfected controls, and medical treatment for hypothyroidism or hyperthyroidism was recorded. Multinomial logistic regression adjusting for known risk factor was used to examine the association between HIV and thyroid dysfunction and multivariate linear regression to study the association between HIV and serum TSH concentrations. RESULTS: The PLWH were generally well treated, with 95% having undetectable viral replication. Among PLWH and controls 31 (3.8%) and 114 (4.6%) had hypothyroidism, and 7 (0.8%) and 21 (0.8%) had hyperthyroidism, respectively. In adjusted analyses, we found no significant associations between HIV and hypothyroidism OR 0.8 [95% confidence interval (CI) 0.6-1.3], P = 0.40 or between HIV and hyperthyroidism OR 1.1 (95% CI 0.5-2.5), P = 0.91. Furthermore, serum TSH concentration was unrelated to HIV status (P = 0.6). CONCLUSION: There was no difference in the prevalence of hyperthyroidism or hypothyroidism in well treated PLWH compared with uninfected controls. HIV status was not associated with thyroid dysfunction or serum TSH concentration.
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“However, 826 well-treated HIV-infected persons, 95% of whom with undetectable viral replication, did not differ from 2,503 uninfected controls for prevalence of hyperthyroidism (0.8 vs. 0.8%) or hypothyroidism (3.8 vs. 4.6%) (56).”
From L-T4 therapy in the presence of pharmacological interferents (2020) · cites this paper as [56]
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Garber, J. R., Cobin, R. H., Gharib, H., Hennessey, J. V., Klein, I., Mechanick, J. I., Pessah-Pollack, R., Singer, P. A., & Woeber, K. A. (2012) · Endocrine Practice · doi:10.4158/ep12280.gl · Cited by 1,567
The epidemiology of thyroid disease
Vanderpump, M. P. J. (2011) · British Medical Bulletin · doi:10.1093/bmb/ldr030 · Cited by 1,179
2013 ETA Guideline: Management of Subclinical Hypothyroidism
Pearce, S. H. S., Brabant, G., Duntas, L. H., Monzani, F., Peeters, R. P., Razvi, S., & Wemeau, J.-L. (2013) · European Thyroid Journal · doi:10.1159/000356507 · Cited by 877
Genetically elevated C-reactive protein and ischemic vascular disease
Zacho, J., Tybjærg-Hansen, A., Jensen, J. S., Grande, P., Sillesen, H., & Nordestgaard, B. G. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0707402 · Cited by 839
Self-citationZandman‐Goddard, G., & Shoenfeld, Y. (2002) · Autoimmunity Reviews · doi:10.1016/s1568-9972(02)00086-1 · Cited by 382
Immune Reconstitution Inflammatory Syndrome: A Reappraisal
French, M. A. (2008) · Clinical Infectious Diseases · doi:10.1086/595006 · Cited by 323
Beltran, S., Lescure, F.-X., Desailloud, R., Douadi, Y., Smaïl, A., Esper, I. E., Arlot, S., Schmit, J., & Thyroid and VIH (THYVI) Group (2003) · Clinical Infectious Diseases · doi:10.1086/376626 · Cited by 103
Ronit, A., Haissman, J. M., Kirkegaard-Klitbo, D. M., Kristensen, T. S., Lebech, A., Benfield, T., Gerstoft, J., Ullum, H., Køber, L., Kjær, A., et al. (2016) · BMC Infectious Diseases · doi:10.1186/s12879-016-2026-9 · Cited by 79
Vejbjerg, P., Knudsen, N. J., Perrild, H., Laurberg, P., Carlé, A., Pedersen, I. B., Rasmussen, L. B., Ovesen, L., & Jørgensen, T. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03493.x · Cited by 64
Grappin, M., Piroth, L., Vergès, B. L., Sgro, C., Mack, G., Buisson, M., Duong, M., Chavanet, P., & Portier, H. (2000) · AIDS · doi:10.1097/00002030-200005260-00026 · Cited by 59
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Microorganisms associated to thyroid autoimmunity
Cuan-Baltazar, Y., & Soto-Vega, E. N. (2020) · Autoimmunity Reviews · doi:10.1016/j.autrev.2020.102614 · Cited by 47
Low prevalence of symptomatic thyroid diseases and thyroid cancers in HIV-infected patients
Properzi, M., della Giustina, T., Mentasti, S., Castelli, F., Chiesa, A., Gregori, N., & Quirós-Roldán, E. (2019) · Scientific Reports · doi:10.1038/s41598-019-56032-7 · Cited by 21
L-T4 therapy in the presence of pharmacological interferents
Benvenga, S. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.607446 · Cited by 13
Characteristics of Graves Disease in HIV-Infected Patients on Antiretroviral Therapy
Jariyawattanarat, V., D, S. S. M., & Sriphrapradang, C. (2020) · Endocrine Practice · doi:10.4158/ep-2019-0514 · Cited by 11
Human immunodeficiency virus, diabetes mellitus and thyroid abnormalities: Should we be screening?
Pillay, S., Pillay, D., Deepak, S., & Pillay, R. (2020) · Southern African Journal of HIV Medicine · doi:10.4102/sajhivmed.v21i1.1116 · Cited by 8
Metadata
- Authors
- Harsløf, M., Knudsen, A. D., Benfield, T., Nordestgaard, B. G., Feldt-Rasmussen, U., & Nielsen, S. D.
- Affiliations
- University of Copenhagen (DK)
- Corresponding author
- Nielsen, Susanne D.
- Venue
- AIDS
- Published
- 2018-09-24
- Volume
- 32
- Issue
- 15
- Pages
- 2195-2199
- ISSN
- 0269-9370 (ISSN-L)
- OpenAlex
- W2883881467
- Cited by
- 19
- References
- 21
- Citations by year
- 2026: 3 · 2025: 3 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 7 · 2019: 2
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- AIDS (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Lundbeckfonden (R164-2013-15414)
- Novo Nordisk Fonden (NNF15OC0014622, NNF14OC0012495)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Keywords
- HIV, thyroid dysfunction, hypothyroidism, hyperthyroidism, thyroid-stimulating hormone, highly active antiretroviral therapy, viral suppression, thyroid function, risk factors
- MeSH terms
- Adolescent, Adult, Aged, Denmark, Female, Humans, Hyperthyroidism, Hypothyroidism, Longitudinal Studies, Male, Middle Aged, Thyroid Hormones, Thyrotropin, HIV Infections, Prevalence, Risk Assessment, Anti-HIV Agents, Young Adult
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