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Cited by 25Cervical Cancer and HPV ResearchHIV/AIDS Research and InterventionsHIV Research and Treatment

Cervical HIV-1 RNA shedding after cryotherapy among HIV-positive women with cervical intraepithelial neoplasia stage 2 or 3

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Chung, Michael H., McKenzie, Kevin P., Richardson, Barbra A., John-Stewart, Grace C., Coombs, Robert W., De Vuyst, Hugo, Njoroge, Julia W., Nyongesa-Malava, Evans +2 more·2011·AIDS
DOI 10.1097/qad.0b013e32834a3654PMC PMC3248579
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Abstract

OBJECTIVE: To determine the effect of cryotherapy on HIV-1 cervical shedding. DESIGN: Prospective cohort study. METHODS: Five hundred HIV-positive women enrolled at an HIV treatment clinic in Nairobi, Kenya were screened for cervical cancer. Women diagnosed with cervical intraepithelial neoplasia stage 2 or 3 (CIN 2/3) by histology were offered cryotherapy treatment. The first 50 women had cervical swabs taken at baseline and at 2 and 4 weeks following treatment. Swabs were analyzed for HIV-1 RNA and compared using General Estimating Equation (GEE) with binomial or Gaussian links. RESULTS: Of the 50 women enrolled, 40 were receiving antiretroviral therapy (ART) and 10 were not receiving ART at the time of cryotherapy and during study follow-up. Among all women, the odds of detectable cervical HIV-1 RNA did not increase at 2 weeks [odds ratio (OR) 1.18; 95% confidence interval (CI) 0.65-2.13] or 4 weeks (OR 1.29; 95% CI 0.71-2.33) following cryotherapy. Among 10 women not receiving ART, the OR of detectable shedding at 2 weeks was higher, but not statistically significant (OR 4.02; 95% CI 0.53-30.79; P = 0.2), and at 4 weeks remained unchanged (OR 1.00; 95% CI 0.27-3.74). CONCLUSION: There was no increase in detectable cervical HIV-1 RNA among HIV-positive women after cryotherapy. The risk of HIV-1 transmission after cryotherapy may not be significant, particularly among women already on ART at the time of cervical treatment. However, further investigation is needed among women not receiving ART.

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Research works printed but not linked: 20

  1. [1]Visual inspection with acetic acid for cervical-cancer screening: test qualities in a primary-care setting. University of Zimbabwe/JHPIEGO Cervical Cancer Project Lancet 1999 353 869 873 10093978
  2. [2]Denny L Kuhn L De Souza M Pollack AE Dupree W Wright TC Jr. Screen-and-treat approaches for cervical cancer prevention in low-resource settings: a randomized controlled trial JAMA 2005 294 2173 2181 16264158
  3. [3]Gaffikin L Blumenthal PD Emerson M Limpaphayom K Safety, acceptability, and feasibility of a single-visit approach to cervical-cancer prevention in rural Thailand: a demonstration project Lancet 2003 361 814 820 12642047
  4. [4]Franceschi S Jaffe H Cervical cancer screening of women living with HIV infection: a must in the era of antiretroviral therapy Clin Infect Dis 2007 45 510 513 17638204
  5. [5]Wright TC Jr Subbarao S Ellerbrock TV Lennox JL Evans-Strickfaden T Smith DG Human immunodeficiency virus 1 expression in the female genital tract in association with cervical inflammation and ulceration Am J Obstet Gynecol 2001 184 279 285 11228474
  6. [6]Kreiss J Willerford DM Hensel M Emonyi W Plummer F Ndinya-Achola J Association between cervical inflammation and cervical shedding of human immunodeficiency virus DNA J Infect Dis 1994 170 1597 1601 7996003
  7. [7]McClelland RS Wang CC Mandaliya K Overbaugh J Reiner MT Panteleeff DD Treatment of cervicitis is associated with decreased cervical shedding of HIV-1 AIDS 2001 15 105 110 11192850
  8. [8]Baeten JM Kahle E Lingappa JR Coombs RW Delany-Moretlwe S Nakku-Joloba E Genital HIV-1 RNA levels predict risk of heterosexual HIV-1 transmission 2011 18th Conference on Retroviruses and Opportunistic Infections Boston
  9. [9]Chung MH McKenzie K De Vuyst H Pamnani R Rana F Njoroge J Comparing visual inspection with acetic acid, high-risk HPV testing, and PAP smear to colposcopic biopsy among HIVR women 2011 18th Conference on Retroviruses and Opportunistic Infections Boston
  10. [10]Chung MH Drake AL Richardson BA Reddy A Thiga J Sakr SR Impact of prior HAART use on clinical outcomes in a large Kenyan HIV treatment program Curr HIV Res 2009 7 441 446 19601781 PMC2735680
  11. [11]John GC Sheppard H Mbori-Ngacha D Nduati R Maron D Reiner M Comparison of techniques for HIV-1 RNA detection and quantitation in cervicovaginal secretions J Acquir Immune Defic Syndr 2001 26 170 175 11242185 PMC3372416
  12. [12]Baeten JM Strick LB Lucchetti A Whittington WL Sanchez J Coombs RW Herpes simplex virus (HSV)-suppressive therapy decreases plasma and genital HIV-1 levels in HSV-2/HIV-1 coinfected women: a randomized, placebo-controlled, cross-over trial J Infect Dis 2008 198 1804 1808 18928378 PMC2665183
  13. [13]Zuckerman RA Lucchetti A Whittington WL Sanchez J Coombs RW Zuniga R Herpes simplex virus (HSV) suppression with valacyclovir reduces rectal and blood plasma HIV-1 levels in HIV-1/HSV-2-seropositive men: a randomized, double-blind, placebo-controlled crossover trial J Infect Dis 2007 196 1500 1508 18008230
  14. [14]Graham SM Holte SE Peshu NM Richardson BA Panteleeff DD Jaoko WG Initiation of antiretroviral therapy leads to a rapid decline in cervical and vaginal HIV-1 shedding AIDS 2007 21 501 507 17301569
  15. [15]Cu-Uvin S Caliendo AM Reinert S Chang A Juliano-Remollino C Flanigan TP Effect of highly active antiretroviral therapy on cervicovaginal HIV-1 RNA AIDS 2000 14 415 421 10770544
  16. [16]Gitau RW Graham SM Masese LN Overbaugh J Chohan V Peshu N Effect of acquisition and treatment of cervical infections on HIV-1 shedding in women on antiretroviral therapy AIDS 2010 24 2733 2737 20871388 PMC2978313
  17. [17]Mwanahamuntu MH Sahasrabuddhe VV Pfaendler KS Mudenda V Hicks ML Vermund SH Implementation of 'see-and-treat' cervical cancer prevention services linked to HIV care in Zambia AIDS 2009 23 N1 5 19279439 PMC2747794
  18. [18]Connor EM Sperling RS Gelber R Kiselev P Scott G O'Sullivan MJ Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment N Engl J Med 1994 331 1173 1180 7935654
  19. [19]John GC Nduati RW Mbori-Ngacha DA Richardson BA Panteleeff D Mwatha A Correlates of mother-to-child human immunodeficiency virus type 1 (HIV-1) transmission: association with maternal plasma HIV-1 RNA load, genital HIV-1 DNA shedding, and breast infections 2001 J Infect Dis 183 206 212 11120927
  20. [20]Lehman DA Chung MH John-Stewart GC Richardson BA Kiarie JN Kinuthia J HIV-1 persists in breast milk cells despite antiretroviral treatment to prevent mother-to-child transmission AIDS 2008 22 1475 1485 18614871 PMC2765916

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Authors
Chung, M. H., McKenzie, K. P., Richardson, B. A., John-Stewart, G. C., Coombs, R. W., De Vuyst, H., Njoroge, J. W., Nyongesa-Malava, E., Sakr, S. R., & Mugo, N. R.
Affiliations
  • University of Washington (US)
  • Fred Hutch Cancer Center (US)
  • Kenyatta National Hospital (KE)
Corresponding author
Chung, Michael H.
ORCID
Venue
AIDS
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2011-09-24
Volume
25
Issue
15
Pages
1915-1919
ISSN
0269-9370 (ISSN-L)
DOI
10.1097/qad.0b013e32834a3654
PMC
PMC3248579
OpenAlex
W2076471277
Cited by
25
References
0
Citations by year
2022: 2 · 2021: 1 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 5 · 2012: 2
FWCI
2.89
Type
journal article
Language
en
Open access
Locations
  • AIDS (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion, other-oa)
  • University of Nairobi Research Archive (University of Nairobi) (submittedVersion)
Funders
  • University of Washington
  • U.S. President’s Emergency Plan for AIDS Relief (U62/CCU024512)
  • Hope Center for Neurological Disorders
  • National Institutes of Health (AI-27757)
  • Centers for Disease Control and Prevention (U62/CCU024512)
  • U.S. Public Health Service (U62/CCU024512-04)
  • Center for AIDS Research, University of Washington
  • National Institute of Allergy and Infectious Diseases (K23AI065222, AI 27757, P30AI027757)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (K24HD054314)
Topics
  • Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Keywords
cervical intraepithelial neoplasia, women living with HIV, antiretroviral therapy, HIV risk factors, cervical cancer screening, cervical cancer treatment
MeSH terms
Adult, Uterine Cervical Dysplasia, Uterine Cervical Neoplasms, Female, Humans, Kenya, Middle Aged, Neoplasm Staging, Prospective Studies, RNA, Viral, Cohort Studies, HIV-1, HIV Infections, Virus Shedding, Cryotherapy

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