Cited by 279HIV-related health complications and treatmentsHIV Research and TreatmentHIV/AIDS Research and Interventions

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. Inflammation and mortality in HIV-infected adults: analysis of the FRAM study cohort.

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Tien, Phyllis C, Choi, Andy I, Zolopa, Andrew R, Benson, Constance, Tracy, Russell, Scherzer, Rebecca, Bacchetti, Peter, Shlipak, Michael, Grunfeld, Carl·2010·JAIDS Journal of Acquired Immune Deficiency Syndromes

DOI 10.1097/qai.0b013e3181e66216PMC PMC2955817

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Abstract

OBJECTIVE: To determine the association of inflammatory markers, fibrinogen, and C-reactive protein (CRP), with 5-year mortality risk. METHODS: Vital status was ascertained in 922 HIV-infected participants from the Study of Fat Redistribution and Metabolic Change in HIV infection. Multivariable logistic regression estimated odds ratios after adjustment for demographic, cardiovascular, and HIV-related factors. RESULTS: Over a 5-year period, HIV-infected participants with fibrinogen levels in the highest tertile (>406 mg/dL) had 2.6-fold higher adjusted odds of death than those with fibrinogen in the lowest tertile (<319 mg/dL). Those with high CRP (>3 mg/L) had 2.7-fold higher adjusted odds of death than those with CRP <1 mg/L. When stratified by CD4 count category, fibrinogen (as a linear variable) remained independently associated [odds ratio (95% confidence intervals)] per 100 mg/dL increase in fibrinogen: 1.93 (1.57 to 2.37); 1.43 (1.14 to 1.79); 1.43 (1.14 to 1.81); and 1.30 (1.04 to 1.63) for CD4 <200, 200-350, >350 to 500, and >500 cells per microliter, respectively. Higher CRP also remained associated with higher odds of death overall and within each CD4 subgroup. CONCLUSIONS: Fibrinogen and CRP are strong and independent predictors of mortality in HIV-infected adults. Our findings suggest that even in those with relatively preserved CD4 counts >500 cells per microliter, inflammation remains an important risk factor for mortality. Further investigation should determine whether interventions to reduce inflammation might decrease mortality risk in HIV-infected individuals.

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Authors: Tien, P. C., Choi, A. I., Zolopa, A. R., Benson, C., Tracy, R., Scherzer, R., Bacchetti, P., Shlipak, M., & Grunfeld, C.
Affiliations: San Francisco VA Medical Center (US)
Stanford Medicine (US)
University of California San Diego (US)
University of California, San Francisco (US)
Corresponding author: Tien, Phyllis C
Choi, Andy I
Scherzer, Rebecca
Shlipak, Michael
ORCID: Tien, Phyllis C
Benson, Constance
Tracy, Russell
Scherzer, Rebecca
Bacchetti, Peter
Shlipak, Michael
Venue: JAIDS Journal of Acquired Immune Deficiency Syndromes
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2010-11-01
Volume: 55
Issue: 3
Pages: 316-322
ISSN: 1525-4135 (ISSN-L)
DOI: 10.1097/qai.0b013e3181e66216
PMC: PMC2955817
OpenAlex: W2046166857
Cited by: 279
References: 28
Citations by year: 2026: 3 · 2025: 6 · 2024: 3 · 2023: 10 · 2022: 16 · 2021: 17 · 2020: 15 · 2019: 13 · 2018: 18 · 2017: 21 · 2016: 26 · 2015: 23 · 2014: 24 · 2013: 31 · 2012: 25
FWCI: 25.25
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: JAIDS Journal of Acquired Immune Deficiency Syndromes (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (2m01rr000083-41)
National Heart, Lung, and Blood Institute (HL-53359, R01HL053359, HL-74814, R01HL074814)
National Institute of Allergy and Infectious Diseases (K23AI066943)
National Institute of Diabetes and Digestive and Kidney Diseases (DK080645, R01DK057508, K23DK080645)
National Center for Research Resources (RR00054, UL1RR024131, RR-00051, RR 0636, M01RR000054, M01RR000051, RR 000 52, M01RR000052, M01-RR000083, RR00865, M01RR000865, RR 00083, M01RR000036)
Topics: Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Keywords: HIV infection, inflammation, mortality, fibrinogen, C-reactive protein, inflammatory markers, CD4 count, mortality risk factors
MeSH terms: Adult, C-Reactive Protein, Female, Fibrinogen, Humans, Inflammation, Male, Middle Aged, Prognosis, HIV Infections, Survival Analysis, CD4 Lymphocyte Count

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. Inflammation and mortality in HIV-infected adults: analysis of the FRAM study cohort.

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