The DOI matches its Crossref record, with a small difference in title or year; 21 of the 21 references it cites were found in a registry or an index.
Development and Validation of a Multi-institutional Preoperative Nomogram for Predicting Grade of Dysplasia in Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas: A Report from The Pancreatic Surgery Consortium
Open accessAbstract
OBJECTIVE: Previous nomogram models for patients undergoing resection of intraductal papillary mucinous neoplasms (IPMNs) have been relatively small single-institutional series. Our objective was to improve upon these studies by developing and independently validating a new model using a large multiinstitutional dataset. SUMMARY BACKGROUND DATA: IPMNs represent the most common radiographically identifiable precursor lesions of pancreatic cancer. They are a heterogenous group of neoplasms in which more accurate markers of high-grade dysplasia or early invasive carcinoma could help avoid unnecessary surgery in 1 case and support potentially curative intervention (resection) in another. METHODS: Prospectively maintained databases from 3 institutions were queried for patients who had undergone resection of IPMNs between 2005 and 2015. Patients were separated into main duct [main and mixed-type (MD)] and branch duct (BD) types based on preoperative imaging. Logistic regression modeling was used on a training subset to develop 2 independent nomograms (MD and BD) to predict low-risk (low- or intermediate-grade dysplasia) or high-risk (high-grade dysplasia or invasive carcinoma) disease. Model performance was then evaluated using an independent validation set. RESULTS: We identified 1028 patients who underwent resection for IPMNs [MD: n = 454 (44%), BD: n = 574 (56%)] during the 10-year study period. High-risk disease was present in 487 patients (47%). Patients with high-risk disease comprised 71% and 29% of MD and BD groups, respectively (P <0.0001). MD and BD nomograms were developed on the training set [70% of total (n = 720); MD: n = 318, BD: n = 402] and validated on the test set [30% (n = 308); MD: n = 136, BD: n = 172]. The presence of jaundice was almost exclusively associated with high-risk disease (57 of 58 patients, 98%). Cyst size >3.0 cm, solid component/mural nodule, pain symptoms, and weight loss were significantly associated with high-risk disease. C-indices were 0.82 and 0.81 on training and independent validation sets, respectively; Brier scores were 0.173 and 0.175, respectively. CONCLUSIONS: For patients with suspected IPMNs, we present an independently validated model for the prediction of high-risk disease.
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“Their logistic regression model to assess the risk of high-grade dysplasia or invasive carcinoma was based on patient characteristics and IPMN imaging features and showed significant stratification between low-risk and high-risk groups.160”
From Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review (2021) · cites this paper as [160]
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Nomograms in oncology: more than meets the eye
Balachandran, V. P., Gönen, M., Smith, J. J., & DeMatteo, R. P. (2015) · The Lancet Oncology · doi:10.1016/s1470-2045(14)71116-7 · Cited by 3,294
Self-citationInternational consensus guidelines 2012 for the management of IPMN and MCN of the pancreas
Tanaka, M., Fernández-del Castillo, C., Adsay, V., Chari, S., Falconi, M., Jang, J.-Y., Kimura, W., Levy, P., Pitman, M. B., Schmidt, C. M., et al. (2012) · Pancreatology · doi:10.1016/j.pan.2012.04.004 · Cited by 2,354
Self-citationTanaka, M., Chari, S. T., Adsay, V. N., Carlos, F.-D., Falconi, M., Shimizu, M., Yamaguchi, K., Yamao, K., & Matsuno, S. (2005) · Pancreatology · doi:10.1159/000090023 · Cited by 2,042
Salvia, R., Castillo, C., Bassi, C., Thayer, S., Falconi, M., Mantovani, W., Pederzoli, P., & Warshaw, A. (2004) · Annals of Surgery · doi:10.1097/01.sla.0000124386.54496.15 · Cited by 783
Intraductal Papillary Mucinous Neoplasms
Schmidt, C. M., White, P. B., Waters, J. A., Yiannoutsos, C. T., Cummings, O. W., Baker, M. S., Howard, T. J., Zyromski, N. J., Nakeeb, A., DeWitt, J. M., et al. (2007) · Annals of Surgery · doi:10.1097/sla.0b013e318155a9e5 · Cited by 413
Self-citationPrecursors to Invasive Pancreatic Cancer
Maitra, A., Fukushima, N., Takaori, K., & Hruban, R. H. (2005) · Advances in Anatomic Pathology · doi:10.1097/01.pap.0000155055.14238.25 · Cited by 290
Self-citationRisk of Morbidity and Mortality Following Hepato-Pancreato-Biliary Surgery
Kneuertz, P. J., Pitt, H. A., Bilimoria, K. Y., Smiley, J. P., Cohen, M. E., Ko, C. Y., & Pawlik, T. M. (2012) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-012-1938-y · Cited by 276
Gaujoux, S., Brennan, M. F., Gonen, M., D’Angelica, M. I., DeMatteo, R., Fong, Y., Schattner, M., DiMaio, C., Janakos, M., Jarnagin, W. R., et al. (2011) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2011.01.016 · Cited by 224
Self-citationLaFemina, J., Katabi, N., Klimstra, D., Correa-Gallego, C., Gaujoux, S., Kingham, T., DeMatteo, R., Fong, Y., D'Angelica, M., Jarnagin, W., et al. (2013) · Annals of Surgical Oncology · doi:10.1245/s10434-012-2702-y · Cited by 113
Self-citationNagai, K., Doi, R., Ito, T., Kida, A., Koizumi, M., Masui, T., Kawaguchi, Y., Ogawa, K., & Üemoto, S. (2009) · Journal of Hepato-Biliary-Pancreatic Surgery · doi:10.1007/s00534-009-0068-8 · Cited by 100
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Ohtsuka, T., Castillo, C. F. F.-D., Furukawa, T., Hijioka, S., Jang, J., Lennon, A. M., Miyasaka, Y., Ohno, E., Salvia, R., Wolfgang, C. L., et al. (2023) · Pancreatology · doi:10.1016/j.pan.2023.12.009 · Cited by 550
Self-citationArtificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review
Kenner, B., Chari, S. T., Kelsen, D., Klimstra, D. S., Pandol, S. J., Rosenthal, M., Rustgi, A. K., Taylor, J. A., Yala, A., Abul-Husn, N., et al. (2021) · Pancreas · doi:10.1097/mpa.0000000000001762 · Cited by 158
Overbeek, K. A., Goggins, M. G., Dbouk, M., Levink, I. J. M., Koopmann, B. D. M., Chuidian, M., Konings, I. C. A. W., Paiella, S., Earl, J., Fockens, P., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2021.10.014 · Cited by 114
Hirono, S., Shimizu, Y., Ohtsuka, T., Kin, T., Hara, K., Kanno, A., Koshita, S., Hanada, K., Kitano, M., Inoue, H., et al. (2019) · Journal of Gastroenterology · doi:10.1007/s00535-019-01617-2 · Cited by 108
Marchegiani, G., Pollini, T., Burelli, A., Han, Y., Jung, H., Kwon, W., Castellanos, D. M. R., Crippa, S., Belfiori, G., Arcidiacono, P. G., et al. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.06.022 · Cited by 107
Metadata
- Authors
- Attiyeh, M. A., Fernández-del Castillo, C., Al Efishat, M., Eaton, A. A., Gönen, M., Batts, R., Pergolini, I., Rezaee, N., Lillemoe, K. D., Ferrone, C. R., Mino-Kenudson, M., Weiss, M. J., Cameron, J. L., Hruban, R. H., D’Angelica, M. I., DeMatteo, R. P., Kingham, T. P., Jarnagin, W. R., Wolfgang, C. L., & Allen, P. J.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Harvard University (US)
- Johns Hopkins University (US)
- Massachusetts General Hospital (US)
- Corresponding author
- Attiyeh, Marc A.
- Batts, Ruqayyah
- DeMatteo, Ronald P.
- Kingham, T. Peter
- Jarnagin, William R.
- Allen, Peter J.
- ORCID
- Venue
- Annals of Surgery
- Published
- 2018-01
- Volume
- 267
- Issue
- 1
- Pages
- 157-163
- ISSN
- 0003-4932 (ISSN-L)
- PMC
- PMC5565720
- OpenAlex
- W2522795941
- Cited by
- 146
- References
- 21
- Citations by year
- 2026: 16 · 2025: 13 · 2024: 17 · 2023: 18 · 2022: 14 · 2021: 21 · 2020: 21 · 2019: 13 · 2018: 9
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Surgery (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA182076, P30CA008748)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Oncology › Neuroendocrine Tumor Research Advances
- Health Sciences › Medicine › Surgery › Cholangiocarcinoma and Gallbladder Cancer Studies
- Keywords
- intraductal papillary mucinous neoplasm, pancreatic IPMN, high-grade dysplasia, invasive carcinoma, preoperative nomogram, pancreatic resection, main duct IPMN, branch duct IPMN, jaundice, cyst size, solid component, risk prediction, pancreatic cancer precursor lesions, multi-institutional validation, prognostic factors, avoiding unnecessary surgery, weight loss
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Adenocarcinoma, Mucinous, Carcinoma, Papillary, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neoplasm Invasiveness, Neoplasm Staging, Pancreatectomy, Pancreatic Neoplasms, Predictive Value of Tests, Prospective Studies, Retrospective Studies, ROC Curve, Carcinoma, Pancreatic Ductal, Nomograms, Young Adult, Preoperative Period
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